Pulmonary emphysema induced by methylphenidate

experimental study

Authors

  • Gabriel Victor Guimarães Rapello Hospital Regional de Mato Grosso do Sul
  • Andréia Antoniolli Universidade Federal de Mato Grosso do Sul (UFMS)
  • Daniel Martins Pereira Universidade Anhanguera-Uniderp
  • Gilberto Facco Universidade Anhanguera-Uniderp
  • Paulo Manuel Pêgo-Fernandes Faculdade de Medicina da Universidade de São Paulo
  • Rogério Pazetti Faculdade de Medicina da Universidade de São Paulo (FMUSP)

Keywords:

Methylphenidate, Attention deficit disorder with hyperactivity, Pulmonary emphysema, Rats, Lung

Abstract

CONTEXT AND OBJECTIVE: Methylphenidate is the most widely used drug for treating attention deficit hyperactivity disorder. However, it has important side effects, such as abdominal pain, insomnia, anorexia and loss of appetite, and also some cases of early severe emphysema after drug abuse have been reported. Our aim was to investigate the development of pulmonary emphysema in rats that were subjected to dif-ferent doses of methylphenidate. DESIGN AND SETTING: Experimental study carried out at the laboratory of a public university. METHODS: Eighteen male Wistar rats were divided into three groups: control (0.9% saline solution); MP 0.8 (methylphenidate, 0.8 mg/kg); MP 1.2 (methylphenidate, 1.2 mg/kg). After 90 days of daily gavage, the ani-mals were sacrificed and lung tissue samples were prepared for analysis on the mean alveolar diameter (Lm). RESULTS: The Lm was greater in MP 0.8 (47.91 ± 3.13; P < 0.01) and MP 1.2 (46.36 ± 4.39; P < 0.05) than in the control group (40.00 ± 3.48). CONCLUSION: Methylphenidate caused an increase in the alveolar diameter of rats, which was compatible with human pulmonary emphysema.

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Author Biographies

Gabriel Victor Guimarães Rapello, Hospital Regional de Mato Grosso do Sul

MSc. Physiotherapist, Hospital Regional de Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil.

Andréia Antoniolli, Universidade Federal de Mato Grosso do Sul (UFMS)

PhD. Associate Professor, Faculdade de Medicina (FAMED), Universidade Federal de Mato Grosso do Sul (UFMS), Campo Grande, Mato Grosso do Sul, Brazil.

Daniel Martins Pereira, Universidade Anhanguera-Uniderp

MSc. Physiotherapist, Hospital Regional de Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil, College Professor, Universidade Anhanguera-Uniderp, Campo Grande, Mato Grosso do Sul, Brazil.

Gilberto Facco, Universidade Anhanguera-Uniderp

MSc. College Professor, Universidade Anhanguera-Uniderp, Campo Grande, Mato Grosso do Sul, Brazil.

Paulo Manuel Pêgo-Fernandes, Faculdade de Medicina da Universidade de São Paulo

MD, PhD. Full Professor, Instituto do Coração (InCor), Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.

Rogério Pazetti, Faculdade de Medicina da Universidade de São Paulo (FMUSP)

PhD. Scientific Researcher, Laboratory of Thoracic Surgery Research, Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, Brazil.

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Published

2015-03-03

How to Cite

1.
Rapello GVG, Antoniolli A, Pereira DM, Facco G, Pêgo-Fernandes PM, Pazetti R. Pulmonary emphysema induced by methylphenidate: experimental study. Sao Paulo Med J [Internet]. 2015 Mar. 3 [cited 2025 Mar. 13];133(2):131-4. Available from: https://periodicosapm.emnuvens.com.br/spmj/article/view/1080

Issue

Vol. 133 No. 2 (2015)

Section

Short Communication

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