Azacitidine and lenalidomide as an alternative treatment for refractory acute myeloid leukemia
a case report
Keywords:
Leukemia, myeloid, acute, Drug therapy, Abnormal karyotype, Angiogenesis inhibitors, AzacitidineAbstract
CONTEXT: Refractory acute myeloid leukemia (AML) is a difficult disease to control with second or third-line chemotherapy regimens. In this report, we describe using azacitidine in combination with lenalido-mide as salvage therapy. CASE REPORT: 52-year-old female was diagnosed with refractory AML and high-risk cytogenetics: com-plex monosomal karyotype consisting of t (3, 3) in association with monosomy 7 and del 5q. Morpho-logical remission associated with maintenance of the cytogenetic abnormality of chromosome 3 and disappearance of the abnormalities relating to chromosomes 5 and 7 was achieved after three cycles of combination therapy with azacitidine and lenalidomide. CONCLUSION: Azacitidine plus lenalidomide can be a therapeutic option for patients with refractory AML, as illustrated in this case.
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