Continuous positive airway pressure (CPAP) after lung resection
a randomized clinical trial
Keywords:
Continuous positive airway pressure, Thoracic surgery, Postoperative complications, Physical therapy specialty, Thoracotomy, Positive-pressure respirationAbstract
CONTEXT AND OBJECTIVE: Noninvasive mechanical ventilation during the postoperative period (PO) following lung resection can restore residual functional capacity, improve oxygenation and spare the inspiratory muscles. The objective of this study was to assess the efficacy of continuous positive airway pressure (CPAP) associated with physiotherapy, compared with physiotherapy alone after lung resection. DESIGN AND SETTING: Open randomized clinical trial conducted in the clinical hospital of Universidade Estadual de Campinas. METHOD: Sessions were held in the immediate postoperative period (POi) and on the first and second postoperative days (PO1 and PO2), and the patients were reassessed on the discharge day. CPAP was applied for two hours and the pressure adjustment was set between 7 and 8.5 cmH2O. The oxygenation index (OI), Borg scale, pain scale and presence of thoracic drains and air losses were evaluated. RESULTS: There was a significant increase in the OI in the CPAP group in the POi compared to the Chest Physiotherapy (CP) group, P = 0.024. In the CP group the OI was significantly lower on PO1 (P = 0,042), than CPAP group. The air losses were significantly greater in the CPAP group in the POi and on PO1 (P = 0.001, P = 0.028), but there was no significant difference between the groups on PO2 and PO3. There was a statistically significant difference between the groups regarding the Borg scale in the POi (P < 0.001), but there were no statistically significant differences between the groups regarding the pain score. CONCLUSION: CPAP after lung resection is safe and improves oxygenation, without increasing the air losses through the drains. CLINICAL TRIAL REGISTRATION: NCT01285648
Downloads
References
Lumbierres M, Prats E, Farrero E, et al. Noninvasive positive pressure ventilation prevents postoperative pulmonary complications in chronic ventilators users. Respir Med. 2007;101(1):62-8.
Bellinetti LM, Thomson JC. Avaliação muscular respiratória nas toracotomias e laparotomias superiores eletivas [Respiratory muscle evaluation in elective thoracotomies and laparotomies of the upper abdomen. J Bras Pneumol. 2006;32(2):99-105.
Perrin C, Jullien V, Vénissac N, et al. Prophylactic use of noninvasive ventilation in patients undergoing lung resectional surgery. Respir Med. 2007;101(7):1572-8.
Benditt JO. Novel uses of noninvasive ventilation. Respir Care. 2009;54(2):212-19; discussion 219-22.
Battisti A, Michotte JB, Tassaux D, van Gessel E, Jolliet P. Non-invasive ventilation in the recovery room for postoperative respiratory failure: a feasibility study. Swiss Med Wkly. 2005;135(23-24):339-43.
Auriant I, Jallot A, Hervé P, et al. Noninvasive ventilation reduces mortality in acute respiratory failure following lung resection. Am J Respir Crit Care Med. 2001;164(7):1231-5.
Aguiló R, Togores B, Pons S, et al. Noninvasive ventilatory support after lung resectional surgery. Chest. 1997;112(1):117-21.
Oken MM, Creech RH, Tormey DC, et al. Toxicity and response criteria of the Eastern Cooperative Oncology Group. Am J Clin Oncol. 1982;5(6):649-55.
Scanlan CL, Myslinski MJ. Terapia de higiene brônquica. In: Scanlan CL, Wilkins RL, Stoller JK, editors. Fundamentos da terapia respiratória de Egan. 7a ed. São Paulo: Manole; 2000. p. 817-43.
Gastaldi AC, Magalhães CMB, Baraúna MA, Silva EMC, Souza HCD. Benefícios da cinesioterapia respiratória no pós-operatório de colecistectomia laparoscópica [Benefits of postoperative respiratory kinesiotherapy following laparoscopic cholecystectomy]. Rev Bras Fisioter. 2008;12(2):100-6.
Celli BR. Chronic respiratory failure after lung resection: the role of pulmonary rehabilitation. Thorac Surg Clin. 2004;14(3):417-28.
Silva LCC. Teste de função pulmonar. In: Silva LCC, Rubin AS, Silva LMC, editores. Condutas em pneumologia. São Paulo: Revinter; 2001. p. 16.
Jaber S, Michelet P, Chanques G. Role of non-invasive ventilation (NIV) in the perioperative period. Best Pract Res Clin Anaesthesiol. 2010;24(2):253-65.
Lefebvre A, Lorut C, Alifano M, et al. Noninvasive ventilation for acute respiratory failure after lung resection: an observational study. Intensive Care Med. 2009;35(4):663-70.
Kindgen-Milles D, Müller E, Buhl R, et al. Nasal-continuous positive airway pressure reduces pulmonary morbidity and length of hospital stay following thoracoabdominal aortic surgery. Chest. 2005;128(2):821-8.
Kallet RH, Diaz JV. The physiologic effects of noninvasive ventilation. Respir Care. 2009;54(1):102-15.
Ferreira HC, Zin WA, Rocco PRM. Fisiopatologia e manejo clínico da ventilação seletiva [Physiopathology and clinical management of one-lung ventilation]. J Bras Pneumol. 2004;30(6):566-73.
Foroulis CN, Kotoulas C, Konstantinou M, Lioulias A. Is the reduction of forced expiratory lung volumes proportional to the lung parenchyma resection, 6 months after pneumonectomy? Eur J Cardiothorac Surg. 2002;21(5):901-5.
Brunelli A, Cassivi SD, Halgren L. Risk factors for prolonged air leak after pulmonary resection. Thorac Surg Clin. 2010;20(3):359-64.
Cavicchia MG, Soares SMTP, Dragosavac D, Araújo S. Ventilação mecânica em pacientes com fístula broncopleural relato de dois casos. Rev Bras Ter Intensiva. 2002;14(2):55-8.
Stolz AJ, Schützner J, Lischke R, Simonek J, Pafko P. Predictors of prolonged air leak following pulmonary lobectomy. Eur J Cardiothorac Surg. 2005;27(2):334-6.
Bardell T, Legare JF, Buth KJ, Hirsch GM, Ali IS. ICU readmission after cardiac surgery. Eur J Cardiothoracic Surg. 2003;23(3):354-9.
Lima VP, Bonfim D, Risso TT, et al. Influência do dreno pleural sobre a dor, capacidade vital e teste de caminhada de seis minutos em pacientes submetidos à ressecção pulmonar [Influence of pleural drainage on postoperative pain, vital capacity and six-minute walk test after pulmonary resection]. J Bras Pneumol. 2008; 34(12):1003-7.
Ambrosino N, Gabbrielli L. Physiotherapy in the perioperative period. Best Pract Res Clin Anaesthesiol. 2010;24(2):283-9.
Agostini P, Singh S. Incentive spirometry following thoracic surgery: what should we be doing?. Physiotherapy. 2009;95(2):76-82.
Overend TJ, Anderson CM, Lucy SD, et al. The effect of incentive spirometry on postoperative pulmonary complications: a systematic review. Chest. 2001;120(3):971-8.