A case of tacrolimus-induced supraventricular arrhythmia after kidney transplantation

Authors

  • Bo-Ra Kim Kosin University College of Medicine
  • Ho-Sik Shin Kosin University College of Medicine
  • Yeon-Soon Jung Kosin University College of Medicine
  • Hark Rim Kosin University College of Medicine

Keywords:

Tacrolimus, Arrhythmias, cardiac, Kidney transplantation, Tachycardia, supraventricular, Atrial premature complexes

Abstract

CONTEXT: Tacrolimus is a potent immunosuppressive drug often administered to transplant recipient patients and exhibits a variety of adverse cardiovascular effects. CASE REPORT: We report a case of a 53-year-old Asian female who developed various arrhythmic phenomena including atrial premature complexes and supraventricular tachycardia after administration of tacrolimus. CONCLUSION: Tacrolimus-associated arrhythmia after kidney transplantation may be life-threatening, and so patients undergoing this procedure should be carefully monitored.

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Author Biographies

Bo-Ra Kim, Kosin University College of Medicine

MD. Fellowship, Department of Internal Medicine, Kosin University College of Medicine, Busan, Korea.

Ho-Sik Shin, Kosin University College of Medicine

MD. Assistant Professor, Kosin University College of Medicine, Gospel Hospital, Busan, Korea.

Yeon-Soon Jung, Kosin University College of Medicine

MD, PhD. Associate Professor, Department of Internal Medicine, Kosin University College of Medicine, Busan, Korea.

Hark Rim, Kosin University College of Medicine

MD, PhD. Professor, Department of Internal Medicine, Kosin University College of Medicine, Busan, Korea.

References

Johnson MC, So S, Marsh JW, Murphy AM. QT prolongation and Torsades de Pointes after administration of FK506. Transplantation. 1992;53(4):929-30.

Hodak SP, Moubarak JB, Rodriguez I, et al. QT prolongation and near fatal cardiac arrhythmia after intravenous tacrolimus administration: a case report. Transplantation. 1998;66(4):535-7.

Minematsu T, Ohtani H, Sato H, Iga T. Pharmacokinetic/ pharmacodynamic analysis of tacrolimus-induced QT prolongation in guinea pigs. Biol Pharm Bull. 1999;22(12):1341-6.

Nishimura M, Kim K, Uchiyama A, et al. Tacrolimus-induced life- threatening arrhythmia in a pediatric liver-transplant patient. Intensive Care Med. 2002;28(11):1683-4.

Marcassi AP, Yasbek DC, Pestana JO, et al. Ventricular arrhythmia in incident kidney transplant recipients: prevalence and associated

factors. Transpl Int. 2011;24(1):67-72.

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Published

2013-05-05

How to Cite

1.
Kim B-R, Shin H-S, Jung Y-S, Rim H. A case of tacrolimus-induced supraventricular arrhythmia after kidney transplantation . Sao Paulo Med J [Internet]. 2013 May 5 [cited 2025 Mar. 12];131(3):205-7. Available from: https://periodicosapm.emnuvens.com.br/spmj/article/view/1308

Issue

Section

Case Report