Paraganglioma of seminal vesicle and chromophobe renal cell carcinoma

a case report and literature review

Authors

  • César Augusto Alvarenga Institute of Molecular Pathology and Immunology, University of Porto
  • José Manuel Lopes Institute of Molecular Pathology and Immunology, University of Porto
  • João Vinagre Institute of Molecular Pathology and Immunology, University of Porto
  • Paula Itagyba Paravidino Institute of Molecular Pathology and Immunology, University of Porto
  • Marcelo Alvarenga Institute of Molecular Pathology and Immunology, University of Porto
  • Adilson Prando Institute of Molecular Pathology and Immunology, University of Porto
  • Lísias Nogueira Castilho Institute of Molecular Pathology and Immunology, University of Porto
  • Paula Soares Institute of Molecular Pathology and Immunology, University of Porto
  • Athanase Billis Institute of Molecular Pathology and Immunology, University of Porto

Keywords:

Paraganglioma, Carcinoma, renal cell, Seminal vesicles, Kidney neoplasms, Mutation

Abstract

CONTEXT: Extra-adrenal paragangliomas are rare tumors that have been reported in many locations, including the kidney, urethra, urinary bladder, prostate, spermatic cord, gallbladder, uterus and vagina. CASE REPORT: This report describes, for the first time to the best of our knowledge, a primary paraganglioma of the seminal vesicle occurring in a 61-year-old male. The patient presented persistent arterial hypertension and a previous diagnosis of chromophobe renal cell carcinoma. It was hypothesized that the seminal vesicle tumor could be a metastasis from the chromophobe renal cell carcinoma. Immunohistochemical characterization revealed expression of synaptophysin and chromogranin in tumor cell nests and peripheral S100 protein expression in sustentacular cells. Succinate dehydrogenase A and B-related (SDHA and SDHB) expression was present in both tumors. CONCLUSIONS: No genetic alterations to the VHL and SDHB genes were detected in either the tumor tissue or tissues adjacent to the tumor, which led us to rule out a hereditary syndrome that could explain the association between paraganglioma and chromophobe renal cell carcinoma in a patient with arterial hypertension.

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Author Biographies

César Augusto Alvarenga, Institute of Molecular Pathology and Immunology, University of Porto

PhD. Pathologist, Institute of Pathology of Campinas (Private Laboratory), Campinas, São Paulo, Brazil, and Fellow at Institute of Molecular Pathology and Immunology, University of Porto (IPATIMUP), Porto, Portugal.

José Manuel Lopes, Institute of Molecular Pathology and Immunology, University of Porto

PhD. Pathologist, Institute of Molecular Pathology and Immunology, University of Porto (IPATIMUP), Porto, Portugal.

João Vinagre, Institute of Molecular Pathology and Immunology, University of Porto

MSc. Researcher, Institute of Molecular Pathology and Immunology, University of Porto (IPATIMUP), Porto, Portugal.

Paula Itagyba Paravidino, Institute of Molecular Pathology and Immunology, University of Porto

MD. Pathologist, Institute of Pathology of Campinas (private laboratory) Campinas, São Paulo, Brazil, and Fellow of Institute of Molecular Pathology and Immunology, University of Porto (IPATIMUP) Porto, Portugal.

Marcelo Alvarenga, Institute of Molecular Pathology and Immunology, University of Porto

PhD. Pathologist, Universidade Estadual de Campinas (Unicamp), and Pathologist, Institute of Pathology of Campinas (Private Laboratory), Campinas, São Paulo, Brazil.

Adilson Prando, Institute of Molecular Pathology and Immunology, University of Porto

PhD. Urologist, Department of Urology, Pontifícia Universidade Católica de Campinas (PUC-Campinas), Campinas, São Paulo, Brazil.

Lísias Nogueira Castilho, Institute of Molecular Pathology and Immunology, University of Porto

PhD. Urologist, Department of Urology, Pontifícia Universidade Católica de Campinas (PUC-Campinas), Campinas, São Paulo, Brazil.

Paula Soares, Institute of Molecular Pathology and Immunology, University of Porto

PhD. Senior Researcher, Institute of Molecular Pathology and Immunology, University of Porto (IPATIMUP), Porto, Portugal.

Athanase Billis, Institute of Molecular Pathology and Immunology, University of Porto

PhD. Titular Professor, Department of Pathology, Universidade Estadual de Campinas (Unicamp), Campinas, São Paulo, Brazil.

References

Tischler AS. Pheochromocytoma and extra-adrenal paraganglioma: updates. Arch Pathol Lab Med. 2008;132(8):1272-84.

Gupta R, Howell RS, Amin MB. Paratesticular paraganglioma: a rare cause of an intrascrotal mass. Arch Pathol Lab Med. 2009;133(5):811-3.

Lee JA, Duh QY. Sporadic paraganglioma. World J Surg. 2008;32(5):683-7.

Erickson D, Kudva YC, Ebersold MJ, et al. Benign paragangliomas: clinical presentation and treatment outcomes in 236 patients. J Clin Endocrinol Metab. 2001;86(11):5210-6.

McNicol AM. Histopathology and immunohistochemistry of adrenal medullary tumors and paragangliomas. Endocr Pathol. 2006;17(4):329-36.

Flickinger CJ. The fine structure and development of the seminal vesicles and prostate in the fetal rat. Z Zellforsch Mikrosk Anat. 1970;109(1):1-14.

van Nederveen FH, Gaal J, Favier J, et al. An immunohistochemical procedure to detect patients with paraganglioma and phaeochromocytoma with germline SDHB, SDHC, or SDHD gene mutations: a retrospective and prospective analysis. Lancet Oncol. 2009;10(8):764-71.

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Published

2012-01-01

How to Cite

1.
Alvarenga CA, Lopes JM, Vinagre J, Paravidino PI, Alvarenga M, Prando A, Castilho LN, Soares P, Billis A. Paraganglioma of seminal vesicle and chromophobe renal cell carcinoma: a case report and literature review. Sao Paulo Med J [Internet]. 2012 Jan. 1 [cited 2025 Mar. 11];130(1):57-60. Available from: https://periodicosapm.emnuvens.com.br/spmj/article/view/1408

Issue

Vol. 130 No. 1 (2012)

Section

Case Report

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