Complete regression of melanocytic nevi
clues for proper diagnosis
Keywords:
Melanocytic nevus, regression, focal acantholytic dyskeratosisAbstract
A histopathological study of a distinct papule isolated from a patient's neck is reported and compared to 80 melanocytic nevi. The histogenesis of this unique tumor indicates that it probably represents the residual of a melanocytic nevus in wich nevi cells have disappeared but fat infiltration and fibrosis of the dermis and the typical aspects of other cutaneous elements persisted. The finding of focal acantholytic dyskeratosis in multiple foci of the lesion may indicate melanocytic cells regression. Lesions with the histopathological appearence of melanocytic nevi, even in the absence of nevi cells, may be discovered scrutinizing the associated alterations.
Downloads
References
ACKERMAN, A. B. - Focal acantholytic dyskeratosis. Arch Dermatol 106:702-706.1972.
BRAITMAN, M. - Junctional nevus with spontaneous clinical disappearance. Arch Dermatol 77:721,1958.
DUPPERRAT, B. - Suppurations folliculaires torpides sous les naevi mlaniyues. Ann Dermatol Syph 81:251-258,1954.
GRAHAM. J. H.; SANDERS, J. B. & JOHNSON, W. C.; et al - Fibrous papule of the nose: a clinicopathological study. J Inv Dermatol 45:194-203,1965.
HABER, H. - Some observations on common moles. Br J Dermatol 74:224-228,1962.
KANTOR, G. R. & WHEELAND, R. G. - Transepidermal elimination of nevus cells. A possible mechanism of nevus involution. Arch Dermatol 123:1371-1374, 1987.
LAMBERT, W. C. - Focal transient acantholytic dermatosis in sites of regression in melanocytic lesions. Abstracts of papers presented at the 24 th, 1986 annual meeting of the American Society of Dermatopathology. J Cutan Pathol 13:452,1986.
LUND, H. Z. & STOBBE, G. D. - The natural history of the pigmented nevus; factors of age and anatomic location. Am J Pathol 25:1117-1155,1949.
MASSI, G.; FEDERICO, F.; CHIARELLI, C.; CELLENO, L. & FERRANTI. G. - Elastic fibers in congenital melanocytic nevus (letter). Arch Dermatol 125:299-300,1989.
MASSON, P. - My conception of cellular nevi. Cancer 4:9-38,1951.
McKIE, R. M. - Melanocytic naevi in Textbook of Dermatology, edited by Rook, A. et alii, Blackwell Scientific Publications, Oxford, London. Edinburgh, Boston, Palo Alto, Melbourne, pp 181-189,1986.
MEHREGAN, A. & STARICCO, R. G. - Elastic fibers in pigmented nevi. J Inv Dermatol 38:271-276,1962.
NICHOLLS, E. M. - Development and elimination of pigmented moles and the anatomical distribution of primary malignant melanoma. Cancer 32:191-195,1973.
ONO, T.; MAH, K. & HU, F. - Dermal melanocytes and elastic fibers. J Cut Pathol 12:468-475,1985.
PINKUS. H. & MEHREGAN, A. H. - Melanocytic and nevocytic tumors and malformations in A Guide to Dermatopathology, edited by Appleton-Century-Crofts, New York. pp 441-466,1976.
SHELLEY, W. B. - Photographic evidence of the spontaneous involution and disappearance of pigment nevi. Arch Dermatol 81:208-209,1960.
SHELLEY, W. B. & ARTHUR, R. P. - Nerve fibers, a neglected component of intradermal cellular nevi. J Inv Dermatol 34:59-65,1960.
STARINK, T. M. & BROWNSTEIN, M. H. - Desmoplastic trichoepithelioma with intradermal nevus: a combined malformation. Abstracts of papers presented at the 24th, 1986 annual meeting of the American Society of Dermatopathology. J Cutan Pathol 13:464,1986.
STEGMAIER, O. C. - Natural regression of the nevus. J Inv Dermatol 32:413-421,1959.
WILSON JONES, E.; MARKS, R. & PONGSEHIRUM, D. - Naevus superficialis lipomatous. Br J Dermatol 93:121-133,1975.
