Epidemiological and serological aspects of hepatitis A among children and teenagers in the city of Santos

a cross-sectional study

Authors

  • Maria Célia Cunha Ciaccia Instituto da Criança, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo and Instituto Adolfo Lutz
  • Regina Célia Moreira Instituto da Criança, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo and Instituto Adolfo Lutz
  • Alexandre Archanjo Ferraro Instituto da Criança, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo and Instituto Adolfo Lutz
  • Marcílio Figueiredo Lemos Instituto da Criança, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo and Instituto Adolfo Lutz
  • Isabel Takano Oba Instituto da Criança, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo and Instituto Adolfo Lutz
  • Gilda Porta Instituto da Criança, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo and Instituto Adolfo Lutz

Keywords:

Prevalence, Hepatitis A, Child, Serology, Epidemiology

Abstract

CONTEXT AND OBJECTIVE: Viral hepatitis A is still a concern at public health level in Brazil and around the world, due both to the number of affected subjects and the possibility of complications in the acute forms. The Brazilian Ministry of Health estimates that at least 70% of this country’s population has already had contact with the hepatitis A virus (HAV). The aim here was to discover the prevalence of serological markers for the hepatitis A virus among children and teenagers at daycare facilities, kindergartens and elementary schools in the city of Santos. DESIGN AND SETTING: Cross-sectional study in kindergartens and elementary schools within the municipal education network in several regions of the city of Santos. METHOD: Students’ family members were surveyed using a questionnaire and 4,680 finger-prick blood samples were taken and assayed by means of the ELISA technique. RESULTS: The general prevalence of anti-HAV IgG was 9.72% and, of these cases, 74.6% were reactive to antiHAV IgM. There was higher prevalence of anti-HAV IgG among older children, females, children who played in streams, those whose homes were not connected to the sewage system, those whose parents had low education levels, those with low household income and those who did not live along the seashore. The prevalence of anti-HAV IgM peaked in the early years and subsequently fell, and it was lower on the hills and in the Northwestern Zone. CONCLUSION: The general prevalence of serological markers for hepatitis A was low in Santos.

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Author Biographies

Maria Célia Cunha Ciaccia, Instituto da Criança, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo and Instituto Adolfo Lutz

MD, Department of Pediatrics, Instituto da Criança (ICR), Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, Brazil.

Regina Célia Moreira, Instituto da Criança, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo and Instituto Adolfo Lutz

MD, PhD. Scientific Researcher, Instituto Adolfo Lutz, São Paulo, Brazil.

Alexandre Archanjo Ferraro, Instituto da Criança, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo and Instituto Adolfo Lutz

MD, PhD. Professor, Department of Pediatrics, Instituto da Criança (ICR), Hospital das Clínicas (HC), Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, Brazil.

Marcílio Figueiredo Lemos, Instituto da Criança, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo and Instituto Adolfo Lutz

MD, PhD. Scientific Researcher, Instituto Adolfo Lutz, São Paulo, Brazil.

Isabel Takano Oba, Instituto da Criança, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo and Instituto Adolfo Lutz

MD, PhD. Scientific Researcher, Instituto Adolfo Lutz, São Paulo, Brazil.

Gilda Porta, Instituto da Criança, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo and Instituto Adolfo Lutz

MD, PhD. Full Professor, Department of Pediatrics, Instituto da Criança (ICR), Hospital das Clínicas (HC), Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, Brazil.

References

Brasil. Ministério da Saúde. Secretaria de Vigilância em Saúde. Departamento de Vigilância Epidemiológica. Hepatites virais: o Brasil está atento. Brasília: Ministério da Saúde; 2005. Available from: http:// portal.saude.gov.br/portal/arquivos/pdf/hepatites_virais_brasil_ atento.pdf. Accessed in 2011 (Nov 29).

Ferreira CT, Silva GL, Barros FC, Ferreira-Lima J. Soroepidemiologia da hepatite A em dois grupos populacionais economicamente distintos de Porto Alegre [Serum epidemiology of hepatitis A in two economically distinct population groups of Porto Alegre]. GED Gastroenterol Endosc Dig. 1996;15(3):85-90.

Pinho JRR, Sumita LM, Moreira RC, et al. Duality of patterns in hepatitis a epidemiology: a study involving two socioeconomically distinct populations in Campinas, São Paulo State, Brazil. Rev Inst Med Trop São Paulo. 1998;40(2):105-6.

Clemens SA, Da Fonseca JC, Azevedo T, et al. Soroprevalência para hepatite A e hepatite B em quatro centros no Brasil [Hepatitis A and hepatiti B seroprevalence in four centers in Brazil]. Rev Soc Bras Med Trop. 2000;33(1):1-10.

Ferreira CT, Silveira TR. Hepatites virais: aspectos da epidemiologia e da prevenção [Viral Hepatitis: epidemiological and preventive aspects]. Rev Bras Epidemiol. 2004;7(4):473-87.

Centro de Vigilância Epidemiológica “Prof. Alexandre Vranjac”. Secretaria de Estado da Saúde São Paulo. Guia de orientações técnicas. Hepatites B e C. São Paulo: Secretaria de Estado da Saúde São Paulo; Centro de Vigilância epidemiológica “Prof. Alexandre Vranjac”; 2002. Available from: ftp://ftp.cve.saude.sp.gov.br/doc_tec/ outros/hepa_guia03.pdf. Accessed in 2011 (Nov 29).

Carrilho FJ, Mendes Clemente C, Silva LC. Epidemiology of hepatitis A and E virus infection in Brazil. Gastroenterol Hepatol. 2005;28(3):118-25.

Tosti ME, Spada E, Romanò L, et al. Acute hepatitis A in Italy: incidence, risk factors and preventive measures. J Viral Hepat. 2008;15 Suppl 2: 26-32.

Franca R, Silva L, Melo MC, et al. Pediatric knowledge about acute viral hepatitis. Braz J Infect Dis. 2004;8(3):227-35.

American Academy of Pediatrics Committee on Infectious Diseases. Hepatitis A vaccine recommendations. Pediatrics. 2007;120(1):189-99.

Dominguez A, Oviedo M, Carmona G, et al. Impact and effectiveness of a mass hepatitis A vaccination programme of preadolescents seven years after introduction. Vaccine. 2008;26(14):1737-41.

Ferreira CT, Silveira TR. Prevenção das hepatites virais através de imunização [Viral hepatitis prevention by immunization]. J Pediatr (Rio J). 2006;82(3 supl):s55-s66.

Stein-Zamir C, Volovik I, Rishpon S. Control of Hepatitis A outbreaks in an endemic community: the role of sustained immunization coverage. Public Health. 2007;121(3):199-201.

de Almeida LM, Azevedo RS, Guimarães AA, et al. Detection of antibodies against hepatitis A virus in eluates of blood spotted on filter-paper: a pilot study in Rio de Janeiro, Brazil. Trans R Soc Trop Med Hyg. 1999;93(4):401-4.

de Alencar Ximenes RA, Martelli CM, Merchán-Hamann E, et al. Multilevel analysis of hepatitis A infection in children and adolescents: a household survey in the Northeast and Central-west regions of Brazil. Int J Epidemiol. 2008;37(4):852-61.

Braga WS, Borges FG, Barros Júnior GM, et al. Prevalence of hepatitis A virus infection: the paradoxical example of isolated communities in the western Brazilian Amazon region. Rev Soc Bras Med Trop. 2009;42(3):277-81.

Al-AzizAM,AwadMA.Seroprevalence of hepatitisAvirus antibodies among a sample of Egyptian children. East Mediterr Health J. 2008;14(5):1028-35.

Kiyohara T, Sato T, Totsuka A, et al. Shifting seroepidemiology of hepatitis A in Japan, 1973-2003. Microbiol Immunol. 2007;51(2):185-91.

Ceyhan M, Yildirim I, Kurt N, et al. Differences in hepatitis A seroprevalence among geographical regions in Turkey: a need for regional vaccination recommendations. J Viral Hepat. 2008;15 Suppl 2:69-72.

Assis SB, Souto FJD, Fontes CJF, Gaspar AMC. Prevalência da infecção pelos vírus das hepatites A e E em escolares de município da Amazônia Matogrossense [Prevalence of hepatitis A and E virus infection in school children of an Amazonian municipality in Mato Grosso State]. Rev Soc Bras Med Trop. 2002;35(2):155-8.

Zago-Gomes MP, Stantolin GC, Perazzio S, et al. Prevalence of anti- hepatitis A antibodies in children of different socioeconomic conditions in Vila Velha, ES. Rev Soc Bras Med Trop. 2005;38(4):285-9.

Michos A, Terzidis A, Kalampoki V, et al. Seroprevalence and risk factors for hepatitis A, B, and C among Roma and non-Roma children in a deprived area of Athens, Greece. J Med Virol. 2008;80(5):791-7.

Vitral CL, Gaspar AM, Souto FJ. Epidemiological pattern and mortality rates for hepatitis A in Brazil, 1980-2002--a review. Mem Inst Oswaldo Cruz. 2006;101(2):119-27.

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Published

2012-07-07

How to Cite

1.
Ciaccia MCC, Moreira RC, Ferraro AA, Lemos MF, Oba IT, Porta G. Epidemiological and serological aspects of hepatitis A among children and teenagers in the city of Santos: a cross-sectional study. Sao Paulo Med J [Internet]. 2012 Jul. 7 [cited 2025 Mar. 9];130(4):230-5. Available from: https://periodicosapm.emnuvens.com.br/spmj/article/view/1486

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