Humoral immunity in Hansen's Disease
Palavras-chave:
Antibodies, Hansen's Disease, Immunity, Cryoglobulins, Immune complexes, ComplementResumo
INTRODUÇÃO: Desde a década de 60, tem-se observado alterações da imunidade humoral na hansenÍase. Os auto-anticorpos apresentam-se em freqüências diversas, nestes pacientes, mais habitualmente na hansenfase virchoviana, em doença de longa evolução e em surtos reacionais. Variação nas freqüências pode se atribuída a diferentes metodologias empregadas na detecção dos anticorpos e ao grupo de doentes selecionado. MATERIAL E MÉTODOS: Esta revisão enfoca os resultados obtidos em diversos estudos de auto-anticorpos, complexos imunes, crioglubulinas, complemento sérico na hanseníase. Destaca-se também, os anticorpos contra glicolipídeos do Mycobacterium leprae, como os antiglicolipídeos fenólicos I, cuja magnitude é variável e depende do patrimônio genético apresentado pelo enfermo.
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