Squamous cell carcinoma arising from chronic lymphedema
case report and review of the literature
Keywords:
Carcinoma, squamous cell, Lymphedema, Skin cancer, Angioedema, Neoplasms, glandular and epithelialAbstract
CONTEXT: Squamous cell carcinoma arising from chronic lymphedema has only been reported in the literature 11 times (12 cases). Some aspects of its pathogenesis remain unclear and, for the first time, attention has been drawn to epidemiological data. CASE REPORT: A 90-year-old white female with chronic unilateral lower-limb lymphedema, secondary to trauma 20 years earlier, presented with a three-month history of a vegetating cutaneous lesion. There had not been any previous local ulceration. The tumor was completely excised and the histopathological analysis showed that it was an infiltrating squamous cell carcinoma. A literature review in the Medline (Medical Literature Analysis and Retrieval System Online) and Lilacs (Literatura Latino-Americana e do Caribe em Ciências da Saúde) databases using the MeSH (Medical Subject Heading) terms “Carcinoma, Squamous Cell” AND “Lymphedema” identified 112 references and found 12 similar case reports.
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References
Lister RK, Black MM, Calonje E, Burnand KG. Squamous cell carcinoma arising in chronic lymphoedema. Br J Dermatol. 1997;136(3):384-7.
Furukawa H, Yamamoto Y, Minakawa H, Sugihara T. Squamous cell carcinoma in chronic lym- phedema: case report and review of the literature. Dermatol Surg. 2002;28(10):951-3.
Bilen BT, Gürlek A, Alaybeyoğlu N, Celik M, Aydin NE. Epidermoid carcinoma arising in chro- nic lymphedema. Eur J Surg Oncol. 2003;29(8):697-8.
Epstein JI, Mendelsohn G. Squamous carcinoma of the foot arising in association long- standing verrucous hyperplasia in a patient with congenital lymphedema. Cancer. 1984;54(5):943-7.
Dandurand M, Bernard F, Barnéon G, Guilhou E, Guillot B, Guilhou JJ. Carcinomes spinocellu- laires multiples sur lymphoedème chronique. Association à un vitiligo [Multiple spinocellu-lar carcinomas on chronic lymphedema. Association with vitiligo]. Ann Dermatol Venereol. 1990;117(12):953-6.
Echenique-Elizondo M, Elorza J. Squamous-cell carcinoma on long-lasting lymphoedema. Lancet Oncol. 2002;3(5):319.
McGrath JA, Schofield OM, Mayou BJ, MacKee PH, Eady RA. Metastatic squamous cell car- cinoma resembling angiosarcoma complicating dystrophic epidermolysis bullosa. Dermato- logica. 1991;182(4):235-8.
Nava VM, Lawrence WT. Liposuction on a lymphedematous arm. Ann Plast Surg. 1988; 21(4):366-8.
Ostrow RS, Manias D, Mitchell AJ, Stawowy L, Faras AJ. Epidermodysplasia verruciformis. A case associated with primary lymphatic dysplasia, depressed cell-mediated immu- nity, and Bowen’s disease containing human papillomavirus 16 DNA. Arch Dermatol. 1987;123(11):1511-6.
Shelley WB, Wood MG. Transformation of the common wart into squamous cell carcinoma in a patient with primary lymphedema. Cancer. 1981;48(3):820-4.
Futrell JW, Myers GH Jr. Regional lymphatics and cancer immunity. Ann Surg. 1973; 177(1):1-7.
Wysocki WM, Komorowski AL, Mitus J. Re: Epidermoid carcinoma arising in chronic lymphe- dema, Bilen et al. Eur J Surg Oncol. 2004;30(1):88.
