The treatment of allergic rhinitis improves the recovery from asthma and upper respiratory infections
Keywords:
Asthma in children, Allergic rhinitis and asthma, Asthma and respiratory infectionAbstract
Forty-six asthmatic children with repeated respiratory infections presented symptoms of allergic rhinitis. All patients were treated locally for allergic rhinitis either with disodium cromoglycate or beclomethasone dipropionate. After six months of treatment, 95% of the children showed improvement of allergic rhinitis and 84% improvement of bronchial asthma, as well as fewer infections. We concluded that allergic rhinitis plays an important role in facilitating infections of the upper respiratory tract, and a possible association of rhinitis, viral infections and bronchial asthma is discussed.
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BOUSHEY, H.A.; HOLTZMAN, M.J.; SHELLER, J.R. & NADEL, J.A. - Bronchial hyperreactivity. Am Rev Resp Dis 121:389-413, 1980.
BUSSE, W.W. - The contribution of viral respiratory infections to the pathogenesis of airway hyperreactivity. Chest 93:1076-1082, 1988.
BUTCHER, B.T.; SALVAGIO, J.E. & LESLIE, G.A. - Secretory and humoral immunologic response of atopic and non atopic individuals to intranasally administered antigen. Clin Allergy 5:33-42, 1975.
CARLSEN, K.H.; ORSTAVIK, I.; LEEGAARD, J.C. & HOES, H. - Respiratory virus infections and aeroallergens in acute bronchial asthma. Arch Dis Child 59:310-315, 1984.
EMPEY, D.N.; LAITINEN, L.A.; JACOBS, L.; GOLD, W.M. & NADEL, J.A. - Mechanism of bronchial hyperreactivity in normal subjects after upper respiratory tract infection. Am Rev Resp Dis 113:131-139, 1976.
FISH, J.E.; ROSENTHAL, R.R.; BARTRA, G.; MENKES, H.; SUMMER, W.; PERMUT, S. & NORMAN, P. - Airway responses to methacholine in allergic and non allergic subjects. Am Rev Resp Dis 113:579-586, 1976.
FREEMAN, G.L. & TODD, R.H. - The role of allergy in viral respiratory tract infections. Am Dis Child 104:330-334, 1962.
FRICK, O.L.; GERMAN, D.E & MILL, J. - Development of allergy in children. I. Association with virus infection. J Allergy Clin Immunol 63:228-241, 1979.
HARRIS, D.M.; MARTIN, L.E.; HARRISON, C. & JACK, D. - The effect of intranasal beclomethasone dipropionate on adrenal function. Clin Allergy 4:291-294, 1974.
LI, J.T.C. & O'CONNELL, E.J. - Viral infections and asthma. Ann Allergy 59:321-331, 1987.
LITTLE, J.W.; HALL, W.J.; DOUGLAS, R.G.; MUDHOLKAR, G.S.; SPEER, D.M. & PATEL, K. - Airway hyperreacitivity and peripheral airway disfunction in influenza A infection. Am Rev Resp Dis 118:295-303, 1978.
MADONINI, E.; BRIATICO-VANGOSA, G.; PAPPACODA, A.; MACCAGNI, G.; CARDANI, A. & SAPOROTI, F. - Seasonal increase of bronchial reactivity in allergic rhinitis. J Allergy Clin Immunol 79:358-363, 1987.
McINTOSH, K.; ELLIS, E.F.; HOFFMAN, L.S.; LYBASS, T.G.; ELLER, J.J. & FULGINITI, V.A. - The association of viral and bacterial respiratory infections with exacerbations of wheezing in young asthmatic children. J Pediatr 82:578-590, 1973.
OULLETE, J.J. & REED, C.E. - Increased response of asthmatic subjects to methacholine after influenza vaccine. J Allergy 36:558-563, 1965.
QUARLES van UFFORD, W.J. & SABELBERG, P.J. - Asiatic influenza in allergic patients with bronchial asthma. In Arch Allergy 15:189-192, 1959.
RAMSDALE, E.H.; MORRIS, M.M.; ROBERTS, R.S. & HARGREAVE, F.E. - Asymptomatic bronchial hyper-responsiveness in rhinitis. J Allergy Clin Immunol 75:573-577, 1985.
SETTIPANE, G.A. - Rhinosinobronchial reflex. In: Settipane GA, ed. Current treatment of ambulatory asthma Providence: NER Allergy Proceedings, 1986, pp. 6-10.
TAYLOR, B.; NORMAN, A.P.; ORGEL, H.A.; STOKES, C.R.; TURNER, M.W. & SOOTHILL, J.F. - Pathogenesis of infantile atopy. Lancet 2:111-113,1973.
TAYLOR, C.E. & TOM, G.L. - Immunoglobulin concentrations in nasopharyngeal secretions. Arch Dis Child 59:48-53, 1984.
TOWNLEY, G.; RYO, U.Y.; KOLOTKIN, B.M. & KANG, B. - Bronchial sensitivity to methacholine in current and former asthmatic and allergic rhinitis patients and control subjects. J Allergy Clin Immunol 56:429-442, 1975.
TUFT, L. & MUELLER, H.L. - In: TUFT, L.; MUELLER, L. eds. Allergy in children Philadelphia: WB Saunders, 1970.
