Histoplasmosis in the nasal septum without pulmonary involvement in a patient with acquired immunodeficiency syndrome
case report and literature review
Keywords:
Histoplasmosis, Acquired immunodeficiency syndrome, Nasal septum, Histoplasma, Human immunodeficiency virus (HIV)Abstract
CONTEXT: Histoplasmosis is a fungal disease caused by inhaling spores of the fungus Histoplasma capsulatum. The spores can be found in soil contaminated with bird, bat or chicken feces. Histoplasmosis occurs worldwide and is one of the most common pulmonary and systemic mycoses. CASE REPORT: We report here the case of a 37-year-old man with acquired immune deficiency syndrome and histoplasmosis in the nasal septum, without pulmonary involvement, that evolved rapidly to disseminated infection, multiple organ failure and death.
Downloads
References
Kauffman CA. Histoplasmosis. Clin Chest Med. 2009;30(2):217-25.
Solari R, Corti M, Cangelosi D, et al. Disseminated histoplasmosis with lesions restricted to the larynx in a patient with AIDS. Report of a case and review of the literature. Rev Iberoam Micol. 2007;24(2):164-6.
Bhagwat PV, Hanumanthayya K, Tophakhane RS, Rathod RM. Two unusual cases of histo- plasmosis in human immunodeficiency virus-infected individuals. Indian J Dermatol Vene- reol Leprol. 2009;75(2):173-6.
K Ramdial P, Mosam A, Dlova NC, et al. Disseminated cutaneous histoplasmosis in patients infected with human immunodeficiency virus. J Cutan Pathol. 2002;29(4):215-25.
Bonifaz A, Chang P, Moreno K, et al. Disseminated cutaneous histoplasmosis in acquired immunodeficiency syndrome: report of 23 cases. Clin Exp Dermatol. 2009;34(4):481-6.
Saheki MN, Schubach AO, Salgueiro MM, et al. Histoplasmose cutânea primária: relato de caso em paciente imunocompetente e revisão de literatura [Primary cutaneous histoplas- mosis: case report on an immunocompetent patient and review of the literature]. Rev Soc Bras Med Trop. 2008;41(6):680-2.
Passoni LFC, Ribeiro SR, Sidi LC, et al. Histoplasmose disseminada como primeira manifes- tação de aids: um diagnóstico tardio demais. Revista Médica. 2003;37(1). Available from: http://www.hse.rj.saude.gov.br/profissional/revista/37/histopla.asp. Accessed in 2010 (May 20).
Mehta V, De A, Balachandran C, Monga P. Mucocutaneous histoplasmosis in HIV with an atypical ecthyma like presentation. Dermatol Online J. 2009;15(4):10.
Felix F, Gomes GA, Pinto PC, et al. Nasal histoplasmosis in the acquired immunodeficiency syndrome. J Laryngol Otol. 2006;120(1):67-9.
Motta AC, Galo R, Lourenço AG, et al. Unusual orofacial manifestations of histoplasmosis in renal transplanted patient. Mycopathologia. 2006;161(3):161-5.
Cappell MS, Mandell W, Grimes MM, Neu HC. Gastrointestinal histoplasmosis. Dig Dis Sci. 1988;33(3):353-60.
Zighelboim J, Goldfarb RA, Mody D, et al. Prostatic abscess due to Histoplasma capsulatum in a patient with the acquired immunodeficiency syndrome. J Urol. 1992;147(1):166-8.
Conces DJ, Stockberger SM, Tarver RD, Wheat LJ. Disseminated histoplasmosis in AIDS: findings on chest radiographs. AJR Am J Roentgenol. 1993;160(1):15-9.
Houston S. Tropical respiratory medicine. 3. Histoplasmosis and pulmonary involvement in the tropics. Thorax. 1994;49(6):598-601.
Williams B, Fojtasek M, Connolly-Stringfield P, Wheat J. Diagnosis of histoplasmo- sis by antigen detection during an outbreak in Indianapolis, Ind. Arch Pathol Lab Med. 1994;118(12):1205-8.
Wheat J, Hafner R, Korzun AH, et al. Itraconazole treatment of disseminated histoplasmosis in patients with the acquired immunodeficiency syndrome. AIDS Clinical Trial Group. Am J Med. 1995;98(4):336-42.
Raza J, Harris MT, Bauer JJ. Gastrointestinal histoplasmosis in a patient with acquired immu- ne deficiency syndrome. Mt Sinai J Med. 1996;63(2):136-40.
Bradsher RW. Histoplasmosis and blastomycosis. Clin Infect Dis. 1996;22 Suppl 2:S102- 11.
Scully C, de Almeida OP, Sposto MR. The deep mycoses in HIV infection. Oral Dis. 1997;3 Suppl 1:S200-7.
Knapp S, Turnherr M, Dekan G, et al. A case of HIV-associated cerebral histoplasmosis successfully treated with fluconazole. Eur J Clin Microbiol Infect Dis. 1999;18(9):658-61.
Ferreira OG, Cardoso SV, Borges AS, Ferreira MS, Loyola AM. Oral histoplasmosis in Brazil. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2002;93(6):654-9.
Cantor AG, John J, Brown B. Metrorrhagia in a human immunodeficiency virus positive wo- man caused by cervical histoplasmosis. Am J Med Sci. 2010;339(3):285-7.
Small P, Levitt P. Disseminated histoplasmosis and necrotizing vasculitis. Can Med Assoc J. 1976;114(2):140-1, 145.
