Glomerular diseases in a Hispanic population

review of a regional renal biopsy database

Authors

  • Luis Fernando Arias University of Antioquia
  • Jorge Henao University of Antioquia
  • Rubén Darío Giraldo University of Antioquia
  • Nelson Carvajal University of Antioquia
  • Joaquin Rodelo University of Antioquia
  • Mario Arbeláez University of Antioquia

Keywords:

Epidemiology, Glomerulonephritis, Hispanic americans, Database, Biopsy

Abstract

CONTEXT AND OBJECTIVE: Epidemiological data provide useful information for clinical practice and investigations. This study aimed to determine glomerular disease frequencies in a region of Colombia and it represents the basis for future studies. DESIGN AND SETTING: Single-center retrospective analysis at the University of Antioquia, Colombia. METHODS: All native renal biopsies (July 1998 to December 2007) were reviewed, but only glomerular diseases were analyzed. The diagnosis of each case was based on histological, immunopathological and clinical features. RESULTS: A total of 1,040 biopsies were included. In 302 cases (29.0%), the patient’s age was ≤ 15 years. Primary glomerular diseases were diagnosed in 828 biopsies (79.6%) and secondary in 212 (20.4%). The most common primary diseases were focal and segmental glomerulosclerosis (FSGS) (34.8%), immunoglobulin A (IgA) nephropathy (IgAN) (11.8%), membranous glomerulonephritis (MGN) (10.6%), minimal change disease (MCD) (10.6%), crescentic glomerulonephritis (GN) (5.6%), and non-IgA mesangial proliferative GN (5.6%). Postinfectious GN represented 10.7% of the diagnoses if included as primary GN. Lupus nephritis corresponded to 17.8% of the entire series. In adults, the order of the most frequent primary diseases was: FSGS, IgAN, MGN, crescentic GN and MCD. In children (≤ 15 years), the most frequent were: FSGS, postinfectious GN, MCD, non-IgA mesangial proliferative GN, endocapillary diffuse GN and IgAN. CONCLUSIONS: As among Afro-Americans, FSGS is the most frequent type of glomerulopathy in our population, but in our group, there are more cases of IgAN. The reasons for these findings are unclear. This information is an important contribution towards understanding the prevalence of renal diseases in Latin America.

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Author Biographies

Luis Fernando Arias, University of Antioquia

MD, PhD. Associate professor, Department of Pathology; and Director of PRYT Group, School of Medicine, University of Antioquia, Medellín, Colombia.

Jorge Henao, University of Antioquia

MD. Titular professor, Section of Nephrology, School of Medicine, University of Antioquia, Medellín, Colombia.

Rubén Darío Giraldo, University of Antioquia

MD. Pathologist, Department of Pathology; and co-investigator in PRYT Group, School of Medicine, University of Antioquia, Medellín, Colombia.

Nelson Carvajal, University of Antioquia

MD. Auxiliary professor, Section of Nephrology, School of Medicine, University of Antioquia, Medellín, Colombia.

Joaquin Rodelo, University of Antioquia

MD. Nephrologist, Section of Nephrology, School of Medicine, University of Antioquia, Medellín, Colombia.

Mario Arbeláez, University of Antioquia

MD. Titular professor, Section of Nephrology, School of Medicine, University of Antioquia, Medellín, Colombia.

References

Nasr SH, Galgano SJ, Markowitz GS, Stokes MB, D’Agati VD. Immunofluorescence on prona- se-digested paraffin sections: a valuable salvage technique for renal biopsies. Kidney Int. 2006;70(12):2148-51.

Churg J, Sobin LH. Renal disease. Classification and atlas of glomerular diseases. Tokyo: Igaku Shoin; 1982.

Parra FC, Amado RC, Lambertucci JR, Rocha J, Antunes CM, Pena SD. Color and genomic ancestry in Brazilians. Proc Natl Acad Sci U S A. 2003;100(1):177-82.

Halevy D, Radhakrishnan J, Appel GB. Racial and socioeconomic factors in glomerular dise- ase. Semin Nephrol. 2001;21(4):403-10.

Korbet SM, Genchi RM, Borok RZ, Schwartz MM. The racial prevalence of glomerular lesions in nephrotic adults. Am J Kidney Dis. 1996;27(5):647-51.

Dragovic D, Rosenstock JL, Wahl SJ, Panagopoulos G, DeVita MV, Michelis MF. Increasing incidence of focal segmental glomerulosclerosis and an examination of demographic pat- terns. Clin Nephrol. 2005;63(1):1-7.

Haas M. Histologic subclassification of IgA nephropathy: a clinicopathologic study of 244 cases. Am J Kidney Dis. 1997;29(6):829-42.

Jennette JC, Wall SD, Wilkman AS. Low incidence of IgA nephropathy in blacks. Kidney Int. 1985;28(6):944-50.

Covic A, Schiller A, Volovat C, et al. Epidemiology of renal disease in Romania: a 10 year review of two regional renal biopsy databases. Nephrol Dial Transplant. 2006;21(2): 419-24.

Rychlík I, Jancová E, Tesar V, et al. The Czech registry of renal biopsies. Occurrence of renal diseases in the years 1994-2000. Nephrol Dial Transplant. 2004;19(12):3040-9.

Briganti EM, Dowling J, Finlay M, et al. The incidence of biopsy-proven glomerulonephritis in Australia. Nephrol Dial Transplant. 2001;16(7):1364-7.

Heaf J, Løkkegaard H, Larsen S. The epidemiology and prognosis of glomerulonephritis in Denmark 1985-1997. Nephrol Dial Transplant. 1999;14(8):1889-97.

Swaminathan S, Leung N, Lager DJ, et al. Changing incidence of glomerular disea- se in Olmsted County, Minnesota: a 30-year renal biopsy study. Clin J Am Soc Nephrol. 2006;1(3):483-7.

Rivera F, López-Gómez JM, Pérez-García R; Spanish Registry of Glomerulonephritis. Frequency of renal pathology in Spain 1994-1999. Nephrol Dial Transplant. 2002;17(9):1594-602.

Li LS, Liu ZH. Epidemiologic data of renal diseases from a single unit in China: analysis based on 13,519 renal biopsies. Kidney Int. 2004;66(3):920-3.

Gesualdo L, Di Palma AM, Morrone LF, et al. The Italian experience of the national registry of renal biopsies. Kidney Int. 2004;66(3):890-4.

Malafronte P, Mastroianni-Kirsztajn G, Betônico GN, et al. Paulista Registry of glomerulone- phritis: 5-year data report. Nephrol Dial Transplant. 2006;21(11):3098-105.

Razukeviciene L, Bumblyte IA, Kuzminskis V, Laurinavicius A. Membranoproliferative glo- merulonephritis is still the most frequent glomerulonephritis in Lithuania. Clin Nephrol. 2006;65(2):87-90.

Simon P, Ramee MP, Boulahrouz R, et al. Epidemiologic data of primary glomerular diseases in western France. Kidney Int. 2004;66(3):905-8.

Nationwide and long-term survey of primary glomerulonephritis in Japan as observed in 1,850 biopsied cases. Research Group on Progressive Chronic Renal Disease. Nephron. 1999;82(3):205-13.

Choi IJ, Jeong HJ, Han DS, et al. An analysis of 4,514 cases of renal biopsy in Korea. Yonsei Med J. 2001;42(2):247-54.

Wirta O, Mustonen J, Helin H, Pasternack A. Incidence of biopsy-proven glomerulonephritis. Nephrol Dial Transplant. 2008;23(1):193-200.

Richards NT, Darby S, Howie AJ, Adu D, Michael J. Knowledge of renal histology al- ters patient management in over 40% of cases. Nephrol Dial Transplant. 1994;9(9): 1255-9.

Fuiano G, Mazza G, Comi N, et al. Current indications for renal biopsy: a questionnaire- based survey. Am J Kidney Dis. 2000;35(3):448-57.

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Published

2009-05-05

How to Cite

1.
Arias LF, Henao J, Giraldo RD, Carvajal N, Rodelo J, Arbeláez M. Glomerular diseases in a Hispanic population: review of a regional renal biopsy database. Sao Paulo Med J [Internet]. 2009 May 5 [cited 2025 Mar. 14];127(3):140-4. Available from: https://periodicosapm.emnuvens.com.br/spmj/article/view/1869

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