Primary malignancy in giant cell tumor

a case report

Authors

  • Rosalvo Zósimo Bispo Júnior Faculdade de Medicina da Universidade de São Paulo
  • Olavo Pires de Camargo Faculdade de Medicina da Universidade de São Paulo
  • Cristiane Marie Ida Faculdade de Medicina da Universidade de São Paulo
  • André Mathias Baptista Faculdade de Medicina da Universidade de São Paulo
  • Marcelo Barbosa Ribeiro Faculdade de Medicina da Universidade de São Paulo
  • José Marcello Bruno Faculdade de Medicina da Universidade de São Paulo
  • Cláudia Regina Gomes Cardim Mendes de Oliveira Faculdade de Medicina da Universidade de São Paulo

Keywords:

Bone neoplasms, Bone tissue, Giant cell tumor of bone, Osteosarcoma, Histiocytoma, malignant fibrous

Abstract

CONTEXT: Primary malignancy in giant cell tumor (PMGCT) is rare. It is defined as a high-grade sarcoma originating in a giant cell tumor (GCT) and seems to behave less aggressively than its secondary counterpart does. CASE REPORT: This report presents the case of a 39-year-old female with pain in her left shoulder for one month. Radiography showed a pathological fracture of the proximal humerus associated with an osteolytic lesion. Histopathological analysis showed typical areas of GCT juxtaposed with a sarcomatous component. CONCLUSIONS: PMGCT seems to behave less aggressively than secondary malignancy in GCT, and it may simulate its more common benign counterpart clinically and radiographically. However, it requires a more aggressive type of treatment.

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Author Biographies

Rosalvo Zósimo Bispo Júnior, Faculdade de Medicina da Universidade de São Paulo

MD, MSc. Traumatologist and orthopedist. PhD student, Department of Orthopedics and Traumatology, Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, Brazil.

Olavo Pires de Camargo, Faculdade de Medicina da Universidade de São Paulo

MD, PhD. Titular professor and Head, Department of Orthopedics and Traumatology, Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, Brazil.

Cristiane Marie Ida, Faculdade de Medicina da Universidade de São Paulo

MD. Pathologist, Division of Anatomical Pathology, Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, Brazil.

André Mathias Baptista, Faculdade de Medicina da Universidade de São Paulo

MD, MSc. Traumatologist and orthopedist. Attending physician, Department of Orthopedics and Traumatology, Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, Brazil.

Marcelo Barbosa Ribeiro, Faculdade de Medicina da Universidade de São Paulo

MD. Traumatologist and orthopedist. Master’s degree student, Department of Orthopedics and Traumatology, Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, Brazil.

José Marcello Bruno, Faculdade de Medicina da Universidade de São Paulo

MD. Traumatologist and orthopedist. Postgraduate student, Department of Orthopedics and Traumatology, Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, Brazil.

Cláudia Regina Gomes Cardim Mendes de Oliveira, Faculdade de Medicina da Universidade de São Paulo

MD, PhD. Pathologist and Head of the Division of Anatomical Pathology, Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, Brazil.

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Published

2009-09-09

How to Cite

1.
Bispo Júnior RZ, Camargo OP de, Ida CM, Baptista AM, Ribeiro MB, Bruno JM, Oliveira CRGCM de. Primary malignancy in giant cell tumor: a case report . Sao Paulo Med J [Internet]. 2009 Sep. 9 [cited 2025 Mar. 9];127(5):310-3. Available from: https://periodicosapm.emnuvens.com.br/spmj/article/view/1910

Issue

Vol. 127 No. 5 (2009)

Section

Case Report

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