HIV heterosexual transmission to stable sexual partners of HIV-infected Brazilian hemophiliacs

Autores

  • José Eduardo Nicolau Hospital Brigadeiro; São Paulo State Health Department; Universidade de São Paulo
  • Gil Benard Hospital Brigadeiro; São Paulo State Health Department; Universidade de São Paulo
  • Luis Augusto Marcondes Fonseca Hospital Brigadeiro; São Paulo State Health Department; Universidade de São Paulo
  • Jorge Simão Rosário Casseb Hospital Brigadeiro; São Paulo State Health Department; Universidade de São Paulo
  • Maria Natomi Sato Hospital Brigadeiro; São Paulo State Health Department; Universidade de São Paulo
  • Marcia Cianga Hospital Brigadeiro; São Paulo State Health Department; Universidade de São Paulo
  • Mauri Massani Tanji Hospital Brigadeiro; São Paulo State Health Department; Universidade de São Paulo
  • Therezinha Ferreira Lorenzi Hospital Brigadeiro; São Paulo State Health Department; Universidade de São Paulo
  • Alberto José da Silva Duarte Hospital Brigadeiro; São Paulo State Health Department; Universidade de São Paulo

Palavras-chave:

HIV Infection, heterosexual transmission, hemophilia, CD4+ lymphocyte

Resumo

Nineteen Brazilian HIV-infected hemophiliacs and their stable heterosexual sexual partners were studied with the aim of assessing the rate of HIV transmission in this at risk group. The mean length of relationship between couples was 7.4 years. The hemophiliac men were Class II (n=6), III (n=11) and IVa (n=2) of the CDC classification. They had decreased CD4+ and elevated CD8+ cell numbers; five had p24 antigenemia. We found 3 HIV-infected women (15.8 percent) by routine and confirmatory tests, a prevalence similar to that seen in other countries. They were asymptomatic and had no detectable p24 antigenemia. The 3 seropositive women's partners were Class II and III-CDC, and had normal CD4+ and CD8+ values and no p24 antigenemia. All seronegative women also had normal CD4+ and CD8+ numbers, except for elevated CD8+ cells in three of them, but immune abnormalities had already been seen in some seronegative partners at high risk for HIV infection. Our results reinforce previous suggestions that heterosexual transmission to stable female partners occurs preferentially early after initiation of sexual exposure, and possibly when the transmitter has high levels of viremia and regular sexual activity.

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Biografia do Autor

José Eduardo Nicolau, Hospital Brigadeiro; São Paulo State Health Department; Universidade de São Paulo

Hospital Brigadeiro, Hemophilia Unit. São Paulo State Health Department, Immunogenetics and Experimental Transplantation Laboratory. Universidade de São Paulo, College of Medicine, LIM 56, São Paulo, São Paulo, Brazil.

Gil Benard, Hospital Brigadeiro; São Paulo State Health Department; Universidade de São Paulo

Hospital Brigadeiro, Hemophilia Unit. São Paulo State Health Department, Immunogenetics and Experimental Transplantation Laboratory. Universidade de São Paulo, College of Medicine, LIM 56, São Paulo, São Paulo, Brazil.

Luis Augusto Marcondes Fonseca, Hospital Brigadeiro; São Paulo State Health Department; Universidade de São Paulo

Hospital Brigadeiro, Hemophilia Unit. São Paulo State Health Department, Immunogenetics and Experimental Transplantation Laboratory. Universidade de São Paulo, College of Medicine, LIM 56, São Paulo, São Paulo, Brazil.

Jorge Simão Rosário Casseb, Hospital Brigadeiro; São Paulo State Health Department; Universidade de São Paulo

Hospital Brigadeiro, Hemophilia Unit. São Paulo State Health Department, Immunogenetics and Experimental Transplantation Laboratory. Universidade de São Paulo, College of Medicine, LIM 56, São Paulo, São Paulo, Brazil.

Maria Natomi Sato, Hospital Brigadeiro; São Paulo State Health Department; Universidade de São Paulo

Hospital Brigadeiro, Hemophilia Unit. São Paulo State Health Department, Immunogenetics and Experimental Transplantation Laboratory. Universidade de São Paulo, College of Medicine, LIM 56, São Paulo, São Paulo, Brazil.

Marcia Cianga, Hospital Brigadeiro; São Paulo State Health Department; Universidade de São Paulo

Hospital Brigadeiro, Hemophilia Unit. São Paulo State Health Department, Immunogenetics and Experimental Transplantation Laboratory. Universidade de São Paulo, College of Medicine, LIM 56, São Paulo, São Paulo, Brazil.

Mauri Massani Tanji, Hospital Brigadeiro; São Paulo State Health Department; Universidade de São Paulo

Hospital Brigadeiro, Hemophilia Unit. São Paulo State Health Department, Immunogenetics and Experimental Transplantation Laboratory. Universidade de São Paulo, College of Medicine, LIM 56, São Paulo, São Paulo, Brazil.

Therezinha Ferreira Lorenzi, Hospital Brigadeiro; São Paulo State Health Department; Universidade de São Paulo

Hospital Brigadeiro, Hemophilia Unit. São Paulo State Health Department, Immunogenetics and Experimental Transplantation Laboratory. Universidade de São Paulo, College of Medicine, LIM 56, São Paulo, São Paulo, Brazil.

Alberto José da Silva Duarte, Hospital Brigadeiro; São Paulo State Health Department; Universidade de São Paulo

Hospital Brigadeiro, Hemophilia Unit. São Paulo State Health Department, Immunogenetics and Experimental Transplantation Laboratory. Universidade de São Paulo, College of Medicine, LIM 56, São Paulo, São Paulo, Brazil.

Referências

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Publicado

1996-05-05

Como Citar

1.
Nicolau JE, Benard G, Fonseca LAM, Casseb JSR, Sato MN, Cianga M, Tanji MM, Lorenzi TF, Duarte AJ da S. HIV heterosexual transmission to stable sexual partners of HIV-infected Brazilian hemophiliacs. Sao Paulo Med J [Internet]. 5º de maio de 1996 [citado 16º de outubro de 2025];114(3):1186-9. Disponível em: https://periodicosapm.emnuvens.com.br/spmj/article/view/1933

Edição

v. 114 n. 3 (1996)

Seção

Breve Comunicado

Licença

Creative Commons License
Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.