Inhibitory serum factor of lymphoproliferative response to allogeneic cells in pregnancy
Palavras-chave:
Mixed lymphocyte culture test, Pregnancy, Habitual abortionResumo
INTRODUÇÃO: A presença de fator sérico inibidor de cultura mista de linfócitos (CML) tem sido associada ao sucesso gesticional observado em mulheres com história de abortameneto de repetição sem etiologia (AER-SED) submetidas a transfusão de linfócitos. OBJETIVO:Investigar se a presença de fator sérico inibidor de CML é essencial para o sucesso gestional. MÉTODO: Soros de 33 gestantes saudáveis e 40 mulheres com AER-SED foram avaliados em CML unidericional, em que os linfócitos das mulheres foram estimulados por linfócitos de seus parceiros ou de indivíduos não aparentados. RESULTADOS: Um efeito inibidor (inibição > 50% quanto comparado com soro normal) foi detectado em 45% das gestantes a partir da 2ªgestação 8% das primegestas, em 29% das abortadeiras primárias e, em 58% das secundárias. CONCLUSÃO: Este fator não parece ser elemento essencial para o sucesso gestional. Portanto, não deve ser considerado parâmetro para avaliação de pacientes com ARE-SED.
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