Does the use of paclitaxel or rapamycin-eluting stent decrease further need for coronary-artery bypass grafting when compared with bare-metal stent?

Authors

  • Hernani Pinto de Lemos Júnior Brazilian Cochrane Center, Universidade Federal de São Paulo — Escola Paulista de Medicina
  • Álvaro Nagib Atallah Brazilian Cochrane Center, Universidade Federal de São Paulo — Escola Paulista de Medicina

Keywords:

Angina pectoris, Coronary artery bypass, Percutaneous transluminal coronary angioplasty, Myocardial revascularization, Thoracic surgery

Abstract

CONTEXT AND OBJECTIVE: The safety and effi cacy of drug-eluting stents reduce the need for surgical revascularization. The objective of the present study was to investigate whether paclitaxel or rapamycin-eluting stent are effective in avoiding the need for coronary-artery bypass grafting. METHODS: This was a systematic review of the literature using the methodology of the Cochrane Collaboration. The type of study considered was controlled randomized trials; the type of intervention was drug-eluting or bare-metal stents; and the main outcome investigated was coronary-artery bypass grafting. RESULTS: The ten studies included in this systematic review did not show any statistically signifi cant difference between the drug-eluting stents and the bare-metal stents with regard to the outcome of coronary-artery bypass grafting (confi dence interval: 0.31 to 1.42). CONCLUSION: The surgical revascularization rate was not reduced by the use of drug-eluting stents.

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Author Biographies

Hernani Pinto de Lemos Júnior, Brazilian Cochrane Center, Universidade Federal de São Paulo — Escola Paulista de Medicina

MD. Assistant in the Brazilian Cochrane Center and Discipline of Evidence-Based Medicine of Universidade Federal de São Paulo – Escola Paulista de Medicina (Unifesp-EPM), São Paulo, Brazil.

Álvaro Nagib Atallah, Brazilian Cochrane Center, Universidade Federal de São Paulo — Escola Paulista de Medicina

MD, PhD. Full professor and Head of the Discipline of Urgent Medicine and Evidence-Based Medicine of Universidade Federal de São Paulo – Escola Paulista de Medicina (Unifesp-EPM). Director of the Brazilian Cochrane Center and Scientifi c Director of Associação Paulista de Medicina (APM), São Paulo, Brazil.

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Published

2007-07-07

How to Cite

1.
Lemos Júnior HP de, Atallah Álvaro N. Does the use of paclitaxel or rapamycin-eluting stent decrease further need for coronary-artery bypass grafting when compared with bare-metal stent?. Sao Paulo Med J [Internet]. 2007 Jul. 7 [cited 2025 Mar. 15];125(4):242-5. Available from: https://periodicosapm.emnuvens.com.br/spmj/article/view/2125

Issue

Section

Systematic Review