The rebound effect in the treatment of complex hemangioma with interferon alpha 2A
Keywords:
Hemangioma, Interferon, Vascular tumorsAbstract
The authors report the case of an infant with an extensive face hemangioma with subglottic airway obstruction which had been successfully treated with interferon alpha 2A but then reoccurred with the same dimensions and airway blockage after treatment was abruptly interrupted. The authors suggest the implementation of a standard procedure for the interruption of interferon alpha 2A treatment in order to avoid this rebound effect and advise on the need for further studies to properly evaluate dosage and administration parameters for interferon alpha 2A in the treatment of difficult hemangioma.
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References
Mulliken JB, Young AE. Vascular birthmarks: hemangiomas and malformations. Philadelphia: WB Saunders Company; 1988.
Ohlms LA, McGill TJ, Jones DT, Healy GB. Interferon alpha 2A: a therapy for airway hemangiomas. Ann Otl Rhinol Laryngol 1994;103:1-8.
White CW, Sondeheimer HM, Crouch EC, Wilson H, Fan LL. Treatment of pulmonary hemangiomantosis with recombinant interferon alpha 2A. New Engl J Med 1989;320:1197-200.
Anger J, Gomes VA, Ernesto JM, Pinus J, Faiwichow G. O tratamento de hemangiomas com interferon alfa 2A. Arq Cient 1997;2:3-6.
The Cochrane Library 1997:Issue 3.
Ezekowitz RAB, Mulliken JB, Folkman J. Interferon alpha 2a therapy for life-threatening hemangiomć in infancy. N Engl J Med 1992;39:76-83.
