Acquired hemoglobin H disease in a patient with aplastic anemia evolving into acute myeloid leukemia

Authors

  • Maria Stella Figueiredo Universidade Federal de São Paulo — Escola Paulista de Medicina
  • Perla Vicari Universidade Federal de São Paulo — Escola Paulista de Medicina
  • Eliza Yuriko Sugano Kimura Universidade Federal de São Paulo — Escola Paulista de Medicina
  • Sandra Vallin Antunes Universidade Federal de São Paulo — Escola Paulista de Medicina
  • Mihoko Yamamoto Universidade Federal de São Paulo — Escola Paulista de Medicina

Keywords:

Hemoglobin H, Disease, Aplastic anemia, Myeloid leukemia, Myelodysplastic syndromes

Abstract

CONTEXT: The prognosis of severe aplastic anemia has improved since the introduction of bone marrow transplantation and treatment with antithymocyte globulin. In contrast to the success of these protocols, studies with long term follow-up have shown the occurrence of clonal diseases such as paroxysmal nocturnal hemoglobinuria, myelodysplastic syndrome and acute leukemia in aplastic anemia. CASE REPORT: We report the first case of a Brazilian patient with aplastic anemia who developed myelodysplastic syndrome and acute myeloid leukemia showing acquired hemoglobin H and increased fetal hemoglobin.

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Author Biographies

Maria Stella Figueiredo, Universidade Federal de São Paulo — Escola Paulista de Medicina

MD, PhD. Discipline of Hematology and Hemotherapy, Universidade Federal de São Paulo — Escola Paulista de Medicina, São Paulo, Brazil.

Perla Vicari, Universidade Federal de São Paulo — Escola Paulista de Medicina

MD. Disciplina de Hematologia e Hemoterapia, Universidade Federal de São Paulo — Escola Paulista de Medicina, São Paulo, Brazil.

Eliza Yuriko Sugano Kimura, Universidade Federal de São Paulo — Escola Paulista de Medicina

BSc. Discipline of Hematology and Hemotherapy, Universidade Federal de São Paulo — Escola Paulista de Medicina, São Paulo, Brazil.

Sandra Vallin Antunes, Universidade Federal de São Paulo — Escola Paulista de Medicina

MD, PhD. Discipline of Hematology and Hemotherapy, Universidade Federal de São Paulo — Escola Paulista de Medicina, São Paulo, Brazil.

Mihoko Yamamoto, Universidade Federal de São Paulo — Escola Paulista de Medicina

MD, PhD. Discipline of Hematology and Hemotherapy, Universidade Federal de São Paulo — Escola Paulista de Medicina, São Paulo, Brazil.

References

Tamura S, Kanamaru A, Takemoto Y, Kakishita E, Nagai K. Clonal evolutions during long-term cultures of bone marrow from de novo acute myeloid leukaemia with trilineage myelo- dysplasia and with myelodysplastic remission marrow. Br J Haematol. 1993;84(2):219-26.

Tichelli A, Gratwohl A, Wursch A, Nissen C, Speck B. Late haematological complications in severe aplastic anaemia. Br J Haematol. 1988;69(3):413-8.

Socié G, Rosenfeld S, Frickhofen N, Gluckman E, Tichelli A. Late clonal diseases of treated aplastic anemia. Semin Hematol. 2000;37(1):91-101.

Kudo S, Harigae H, Watanabe N, et al. Increased HbF levels in dyserythropoiesis. Clin Chim Acta. 2000;291(1):83-7.

Annino L, Di Giovanni S, Tentori L, et al. Acquired hemoglobin H disease in a case of refractory anemia with excess of blasts (RAEB) evolving into acute nonlymphoid leukemia. Acta Haemat. 1984;72(1):41-4.

Barrett J, Saunthararajah Y, Molldrem J. Myelodysplastic syndrome and aplastic anemia: distinct entities or dis- eases linked by a common pathophysiology? Semin Hematol. 2000;37(1):15-29.

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Published

2004-11-11

How to Cite

1.
Figueiredo MS, Vicari P, Kimura EYS, Antunes SV, Yamamoto M. Acquired hemoglobin H disease in a patient with aplastic anemia evolving into acute myeloid leukemia. Sao Paulo Med J [Internet]. 2004 Nov. 11 [cited 2025 Mar. 18];122(6):273-5. Available from: https://periodicosapm.emnuvens.com.br/spmj/article/view/2554

Issue

Section

Case Report