Height, weight, weight change and risk of breast cancer in Rio de Janeiro, Brazil
Palavras-chave:
Câncer de mama, Peso corporal, Estatura, Alterações ponderaisResumo
CONTEXTO: A relação entre o peso corporal e o câncer de mama ainda permanece controversa ao ser considerado o estado menopausal. OBJETIVO: Avaliar a associação entre altura, peso e modificações no peso corporal com câncer de mama no município do Rio de Janeiro, Brasil. LOCAL: Instituto Nacional de Câncer (INCA), Rio de Janeiro, Brasil/ Universidade do Estado do Rio de Janeiro (UERJ). POPULAÇÃO DE ESTUDO: 177 casos incidentes de câncer de mama invasivo admitidas no principal hospital do INCA, entre maio de 1995 e fevereiro de 1996, e 377 controles recrutados entre mulheres que visitavam pacientes no mesmo hospital. COLETA DE DADOS: Foram aferidos peso e altura e as informações sobre peso máximo, peso aos 18 e 30 anos, fatores de risco potenciais relacionados à história familiar de câncer de mama, história reprodutiva e escolaridade foram obtidas através de entrevista realizada no próprio hospital. RESULTADOS: A altura não se mostrou relacionada ao risco de câncer de mama entre as mulheres pré e pós-menopausa; entretanto, as mulheres estudadas apresentaram estaturas inferiores às relatadas em estudos que reportaram associação. Entre as mulheres na pré-menopausa o índice de massa corporal (IMC) recente e o IMC máximo associou-se negativamente ao risco de câncer de mama (P da tendência ≤ 0,03). Perda de peso entre os 18 e 30 anos de idade e entre os 18 anos e a idade presente foi associada com o aparecimento de câncer de mama antes da menopausa. CONCLUSÕES: Esses achados podem indicar, meramente, a conhecida associação entre magreza e câncer de mama. Estudos futuros deveriam explorar o papel da perda de peso para o risco de câncer de mama.
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