Impact of surgical volume and specialist availability on thyroidectomy outcomes in Brazil: an ecological study with a nationwide retrospective analysis of 230,345 cases (2008–2023)

Authors

Keywords:

Thyroid, Thyroidectomy, Cancer of head and neck, Specialist, Surgeon, Head and neck, Thyroid disease, Public health, Epidemiology, Medical specialization

Abstract

INTRODUCTION: Thyroid disorders affect a significant proportion of the population and often necessitate surgical intervention, particularly in cases of malignancy. In this study, we analyzed thyroidectomy procedures performed within the public health system (SUS) of Brazil from 2008 to 2023, with a focus on factors influencing in-hospital mortality.

METHODS: In the retrospective analysis, data on 230,345 thyroidectomies were extracted from SUS records and stratified by hospital volume and state-level distribution of head and neck specialists. Mortality rates were evaluated using non-parametric statistical analyses, including the Kruskal–Wallis and Spearman’s correlation tests.

RESULTS: The overall in-hospital mortality rate was 0.15%. States with fewer than 0.5 head and neck specialists per 100,000 inhabitants exhibited significantly higher mortality rates (0.2 versus 0.15, p = 0.02). Hospitals performing fewer than 25 procedures annually (very low-volume) had a fivefold increase in mortality compared with high-volume hospitals (0.51 versus 0.10, p < 0.001). When hospitals performing fewer than 10 procedures per year were excluded, significant differences in mortality among volume groups were no longer observed.

CONCLUSION: Mortality increased significantly in very low-volume hospitals performing fewer than 25 thyroidectomies per year; however, this difference was no longer observed after excluding hospitals that performed fewer than 10 interventions per year. These results support restricting thyroidectomies to hospitals performing at least 10 procedures annually and promoting centralization to improve outcomes. Structured regionalization policies are needed to ensure equitable access to specialized surgical care across Brazil.

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Author Biographies

Ricardo Yugi Eri, Hospital Albert Einstein, São Paulo (SP), Brazil

MD. Medical Resident, Hospital Albert Einstein, São Paulo (SP), Brazil.

Leandro Luongo Matos, Faculdade Israelita de Ciências da Saúde Albert Einstein, Hospital Albert Einstein, São Paulo (SP), Brazil

PhD. Full Professor, Faculdade Israelita de Ciências da Saúde Albert Einstein, Hospital Albert Einstein, São Paulo (SP), Brazil; Departamento de Cirurgia de Cabeça e Pescoço, Instituto do Câncer do Estado de São Paulo, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo (HC-FMUSP), São Paulo (SP), Brazil.

Marcelo Passos Teivelis, Faculdade Israelita de Ciências da Saúde Albert Einstein, Hospital Albert Einstein, São Paulo (SP), Brazil

PhD. Assistant Professor, Faculdade Israelita de Ciências da Saúde Albert Einstein, Hospital Albert Einstein, São Paulo (SP), Brazil.

Nelson Wolosker , Faculdade Israelita de Ciências da Saúde Albert Einstein, Hospital Albert Einstein, São Paulo (SP), Brazil

PhD. Dean, Faculdade Israelita de Ciências da Saúde Albert Einstein, Hospital Albert Einstein, São Paulo (SP), Brazil.

Ana Kober Nogueira Leite, , Faculdade Israelita de Ciências da Saúde Albert Eintein; Instituto e Pesquisa Albert Einstein, Hospital Albert Einstein, São Paulo (SP), Brazil

PhD. Assistant Professor, Faculdade Israelita de Ciências da Saúde Albert Eintein; Instituto e Pesquisa Albert Einstein, Hospital Albert Einstein, São Paulo (SP), Brazil; Departamento de Cirurgia de Cabeça e Pescoço, Instituto do Câncer do Estado de São Paulo, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo (HC-FMUSP), São Paulo (SP), Brazil.

References

Bensenor IM. Thyroid disorders in Brazil: the contribution of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). Braz J Med Biol Res. 2019;52(2):e8417. PMID: 30785482; https://doi.org/10.1590/1414-431X20198417.

Haugen BR, Alexander EK, Bible KC, et al. 2015 American Thyroid Association management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer: The American Thyroid Association guidelines task force on thyroid nodules and differentiated thyroid cancer. Thyroid. 2016;26(1):1–133. PMID: 26462967; https://doi.org/10.1089/thy.2015.0020.

Lortet-Tieulent J, Franceschi S, Dal Maso L, Vaccarella S. Thyroid cancer “epidemic” also occurs in low- and middle-income countries. Int J Cancer. 2019;144(9):2082–7. PMID: 30242835; https://doi.org/10.1002/ijc.31884.

Kitahara CM, Schneider AB. Epidemiology of thyroid cancer. Cancer Epidemiol Biomarkers Prev. 2022;31(7):1284–97. PMID: 35775227; https://doi.org/10.1158/1055-9965.EPI-21-1440.

Cernea CR, Matos LL, Eugênio C, et al. Active surveillance of thyroid microcarcinomas: a critical view. Curr Oncol Rep. 2022;24(1):69–76. PMID: 35061193; https://doi.org/10.1007/s11912-021-01177-w.

Braga JP, Barros Bentes LG, Lemos RS, et al. Profile of thyroidectomies in Brazil from 2010 to 2020 from a macro-regional perspective. Arch Endocrinol Metab. 2023;67(3):372–7. PMID: 37011372; https://doi.org/10.20945/2359-3997000000590.

Loyo M, Tufano RP, Gourin CG. National trends in thyroid surgery and the effect of volume on short-term outcomes. Laryngoscope. 2013;123(8):2056–63. PMID: 23737403; https://doi.org/10.1002/lary.23923.

Vashishta R, Mahalingam-Dhingra A, Lander L, Shin EJ, Shah RK. Thyroidectomy outcomes: a national perspective. Otolaryngol Head Neck Surg. 2012;147(6):1027–34. PMID: 22807486; https://doi.org/10.1177/0194599812454401.

Liang TJ, Liu SI, Mok KT, Shi HY. Associations of volume and thyroidectomy outcomes: a nationwide study with systematic review and meta-analysis. Otolaryngol Head Neck Surg. 2016;155(1):65–75. PMID: 26932961; https://doi.org/10.1177/0194599816634627.

Cavalheiro BG, Matos LL, Leite AK, et al. Surgical treatment for thyroid carcinoma: retrospective study with 811 patients in a Brazilian tertiary hospital. Arch Endocrinol Metab. 2016;60(5):472–8. PMID: 27737324; https://doi.org/10.1590/2359-3997000000209.

Lorenz K, Raffaeli M, Barczyński M, Lorente-Poch L, Sancho J. Volume, outcomes, and quality standards in thyroid surgery: an evidence-based analysis-European Society of Endocrine Surgeons (ESES) positional statement. Langenbecks Arch Surg. 2020;405(4):401–25. Erratum in: Langenbecks Arch Surg. 2022;407(8):3913. PMID: 32524467; https://doi.org/10.1007/s00423-021-02257-y.

Ministério da Saúde. Informações de Saúde (TABNET) [Internet]. DATASUS. 2025 [cited 2026 Jan 7]. Available from: https://datasus.saude.gov.br/informacoes-de-saude-tabnet/.

Mário Scheffer, editor. Demografia médica no Brasil 2023. São Paulo: FMUSP; AMB; 2023. 344 p.

Instituto Brasileiro de Geografia e Estatística (IBGE). Pesquisa nacional de saúde 2019: indicadores de saúde e mercado de trabalho. Rio de Janeiro: IBGE; 2020.

Macinko J, Harris MJ. Brazil’s family health strategy: delivering community-based primary care in a universal health system. N Engl J Med. 2015;372(23):2177–81. PMID: 26039598; https://doi.org/10.1056/NEJMp1501140.

Ward LS, Scheffel RS, Hoff AO, Ferraz C, Vaisman F. Response to the letter to the editor: Thyroid surgery volume, a statement issued by the Brazilian Head and Neck Surgery Society (SBCCP). Arch Endocrinol Metab. 2024;68:e240066. PMID: 39420897; https://doi.org/10.20945/2359-4292-2024-0066.

Matos FCM, Vartanian JG, Barauna JC, et al. Thyroid surgery volume, a statement issued by the Brazilian Head and Neck Surgery Society (SBCCP). Arch Endocrinol Metab. 2024;68:e240064. PMID: 39420898; https://doi.org/10.20945/2359-4292-2024-0064.

Stopenski S, Grigorian A, Roditi R, et al. Discrepancies in thyroidectomy outcomes between general surgeons and otolaryngologists. Indian J Otolaryngol Head Neck Surg. 2022;74(Suppl 3):5384–90. PMID: 36742886; https://doi.org/10.1007/s12070-021-02650-5.

Kovatch KJ, Hoban CW, Shuman AG. Thyroid cancer surgery guidelines in an era of de-escalation. Eur J Surg Oncol. 2018;44(3):297–306. PMID: 28385370; https://doi.org/10.1016/j.ejso.2017.03.005.

Sheetz KH, Chhabra KR, Smith ME, Dimick JB, Nathan H. Association of discretionary hospital volume standards for high-risk cancer surgery with patient outcomes and access, 2005-2016. JAMA Surg. 2019;154(11):1005–12. PMID: 31411663; https://doi.org/10.1001/jamasurg.2019.3017.

Szor DJ, Tustumi F. The influence of institutional pancreaticoduodenectomy volume on short-term outcomes in the Brazilian public health system: 2008-2021. Rev Col Bras Cir. 2023;50:e20233569. PMID: 37646727; https://doi.org/10.1590/0100-6991e-20233569-en.

Birkmeyer JD, Stukel TA, Siewers AE, et al. Surgeon volume and operative mortality in the United States. N Engl J Med. 2003;349(22):2117–27. PMID: 14645640; https://doi.org/10.1056/NEJMsa035205.

Al-Qurayshi Z, Robins R, Hauch A, Randolph GW, Kandil E. Association of surgeon volume with outcomes and cost savings following thyroidectomy: a national forecast. JAMA Otolaryngol Head Neck Surg. 2016;142(1):32–9. PMID: 26561736; https://doi.org/10.1001/jamaoto.2015.2503.

Huston-Paterson H, Mao Y, Tseng CH, et al. Disparities in initial thyroid cancer care by hospital treatment volume: analysis of 52,599 cases in California. Thyroid. 2023;33(10):1215–23. PMID: 37498775; https://doi.org/10.1089/thy.2023.0241.

Tustumi F, Portilho AS, Teivelis MP, et al. The impact of the institutional abdominoperineal resections volume on short-term outcomes and expenses: a nationwide study. Tech Coloproctol. 2023;27(8):647–53. PMID: 36454374; https://doi.org/10.1007/s10151-022-02733-7.

Tracy ET, Bennett KM, Danko ME, et al. Low volume is associated with worse patient outcomes for pediatric liver transplant centers. J Pediatr Surg. 2010;45(1):108–13. PMID: 20105589; https://doi.org/10.1016/j.jpedsurg.2009.10.018.

Asbun HJ, Moekotte AL, Vissers FL, et al.; International Study Group on Minimally Invasive Pancreas Surgery (I-MIPS). The Miami International Evidence-Based Guidelines on Minimally Invasive Pancreas Resection. Ann Surg. 2020;271(1):1–14. PMID: 31567509; https://doi.org/10.1097/SLA.0000000000003590.

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Published

2026-05-14

How to Cite

1.
Eri RY, Matos LL, Teivelis MP, Wolosker N, Leite AKN. Impact of surgical volume and specialist availability on thyroidectomy outcomes in Brazil: an ecological study with a nationwide retrospective analysis of 230,345 cases (2008–2023). Sao Paulo Med J [Internet]. 2026 May 14 [cited 2026 Jun. 10];144(2):1-8. Available from: https://periodicosapm.emnuvens.com.br/spmj/article/view/2938

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