Sleep quality and levels of stress, anxiety, and depression in patients treated with homeopathy: a prospective study in the Brazilian public healthcare service
Keywords:
Homeopathy, Sleep disorders, Anxiety, Depression, Stress disorders, Health promotion, Chronic noncommunicable diseases, NCD, Homeopathic treatment, Public health, Sleep qualityAbstract
BACKGROUND: Chronic noncommunicable diseases (NCDs) have a multifactorial etiology and are associated with psychosocial factors, such as stress, anxiety, and depression. Sleep quality also influences general health and is associated with obesity and NCDs. Homeopathy, as a medical specialty, is effective in managing these conditions because of its comprehensive approach to individuals.
OBJECTIVE: To evaluate the influence of homeopathic treatment on sleep quality and levels of stress, anxiety, and depression.
DESIGN AND SETTING: Observational, longitudinal, and prospective study on individuals over 18 years of age with homeopathic medical follow-up for 6 months in the public healthcare service of Guarulhos, São Paulo.
METHODS: Participants were evaluated initially (T0) and after 3 (T1) and 6 months (T2) using validated questionnaires (Pittsburgh Sleep Quality Index and the Depression Anxiety and Stress Scale), following all ethical precepts. The scores were compared over time and correlated with each other (P < 0.05).
RESULTS: The mean patient age was 49 years. Initially, 81% of the participants had sleep disorders and severe or extremely severe levels of stress (33.78%), anxiety (28.38%), and depression (27.03%). A total of 26 patients were present at the three evaluation points, which were included as the participants of the study. Homeopathic treatment significantly improved sleep quality and reduced stress, anxiety, and depression. Sleep quality and anxiety were strongly (r = 0.53, P = 0.005) and weakly (r = 0.25, P = 0.021) correlated with stress, respectively.
CONCLUSION: In the short term, homeopathic treatment had a positive impact on the sample, suggesting that this therapy can be used to prevent NCDs.
Downloads
References
Brasil. Ministério da Saúde. Secretaria de Vigilância em Saúde. Departamento de Análise em Saúde e Vigilância de Doenças Não Transmissíveis. Plano de ações estratégicas para o enfrentamento das doenças crônicas e agravos não transmissíveis no Brasil, 2021-2030. Panorama da mortalidade por doenças crônicas não transmissíveis e fatores de risco associados no Brasil. Brasília, DF: Ministério da Saúde; 2021 [cited 2025 Aug 8]. Available from: https://www.gov.br/saude/pt-br/centrais-de-conteudo/publicacoes/publicacoes-svs/doencas-cronicas-nao-transmissiveis-dcnt/09-plano-de-dant-2022_2030.pdf/view.
Brasil. Ministério da Saúde. Diretrizes e Recomendações para o Cuidado Integral de Doenças crônicas Não Transmissíveis: promoção da saúde, vigilância, prevenção e assistência. Brasília, DF: Ministério da Saúde; 2008 [cited 2025 Aug 8]. Available from: https://bvsms.saude.gov.br/bvs/publicacoes/diretrizes_recomendacoes_cuidado_doencas_cronicas.pdf.
WHO reveals leading causes of death and disability worldwide: 2000-2019. World Health Organization (WHO) [Internet]. 2020 [cited 2025 Aug 8]. Available from: https://www.who.int/news/item/09-12-2020-who-reveals-leading-causes-of-death-and-disability-worldwide-2000-2019.
Sagner M, Katz D, Egger G, et al. Lifestyle medicine potential for reversing a world of chronic disease epidemics: from cell to community. Int J Clin Pract. 2014;68(11):1289–92. PMID: 25348380; https://doi.org/10.1111/ijcp.12509.
Silva EL, Braga MFT, Carminatti CM, et al. A relação intrínseca entre a privação de sono e obesidade: uma revisão integrativa. Braz J Develop [Internet]. 2023;9(8):24582–99. Available from: https://ojs.brazilianjournals.com.br/ojs/index.php/BRJD/article/view/62265.
Chamorro RA, Durán SA, Reyes SC, et al. La reducción del sueño como factor de riesgo para obesidad [Sleep deprivation as a risk factor for obesity]. Rev Med Chil. 2011;139(7):932–40. Spanish. PMID: 22051834.
Hahnemann S. Exposition of the homeopathic doctrine or organon of the art of healing. 7. ed. São Paulo: Grupo de Estudos Homeopáticos de São Paulo (GEHSP) “Benoit Mure”; 2019.
Hahnemann S. Chronic diseases: their peculiar nature and their homeopathic cure. 8. ed. São Paulo: Grupo de Estudos Homeopáticos de São Paulo (GEHSP) “Benoit Mure”; 2020.
Brasil. Ministério da Saúde. Secretaria de Atenção à Saúde. Departamento de Atenção Básica. Política Nacional de Práticas Integrativas e Complementares no SUS (PNPIC-SUS). 2. ed. Brasília, DF: Ministério da Saúde; 2015. Available from: https://bvsms.saude.gov.br/bvs/publicacoes/politica_nacional_atencao_basica.pdf.
Passos MH, Silva HA, Pitangui AC, et al. Reliability and validity of the Brazilian version of the Pittsburgh Sleep Quality Index in adolescents. J Pediatr (Rio J). 2017;93(2):200–6. PMID: 27520731; https://doi.org/10.1016/j.jped.2016.06.006.
Buysse DJ, Reynolds CF 3rd, Monk TH, Berman SR, Kupfer DJ. The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. Psychiatry Res. 1989;28(2):193–213. PMID: 2748771; https://doi.org/10.1016/0165-1781(89)90047-4.
Farah NM, Saw Yee T, Mohd Rasdi HF. Self-reported sleep quality using the Malay version of the Pittsburgh Sleep Quality Index (PSQI-M) in Malaysian adults. Int J Environ Res Public Health. 2019;16(23):4750. PMID: 31783607; https://doi.org/10.3390/ijerph16234750.
Bengwasan PD, Bernardo ABI, Maximo SI. Translation and initial validation of the Depression Anxiety and Stress Scale (DASS-21) in Ilokano. Psychol Stud (Mysore). 2022;67(4):594–604. PMID: 36407971; https://doi.org/10.1007/s12646-022-00696-1.
Makara-Studzińska M, Tyburski E, Załuski M, et al. Confirmatory factor analysis of three versions of the Depression Anxiety Stress Scale (DASS-42, DASS-21, and DASS-12) in Polish adults. Front Psychiatry. 2022;12:770532. PMID: 35058818; https://doi.org/10.3389/fpsyt.2021.770532.
Cohen BE, Edmondson D, Kronish IM. State of the art review: depression, stress, anxiety, and cardiovascular disease. Am J Hypertens. 2015;28(11):1295–302. PMID: 25911639; https://doi.org/10.1093/ajh/hpv047.
Lima MG, Barros MBA, Malta DC, Medina LPB, Szwarcwald CL. Association of self-reported sleep problems with morbidities and multimorbidities according to sex: national health survey, 2019. Epidemiol Serv Saude. 2022;31(1):e2021386. PMID: 35730889; https://doi.org/10.1590/SS2237-9622202200007.especial.
Gajardo YZ, Ramos JN, Muraro AP, et al. Problemas com o sono e fatores associados na população brasileira: pesquisa nacional de saúde, 2013 [Sleep-related problems and associated factors among the Brazilian population: National Health Survey, 2013]. Cien Saude Colet. 2021;26(2):601–10. Portuguese. PMID: 33605337; https://doi.org/10.1590/1413-81232021262.08412020.
Kwok CS, Kontopantelis E, Kuligowski G, et al. Self-reported sleep duration and quality and cardiovascular disease and mortality: a dose-response meta-analysis. J Am Heart Assoc. 2018;7(15):e008552. PMID: 30371228; https://doi.org/10.1161/JAHA.118.008552.
Troxel WM, Buysse DJ, Matthews KA, et al. Sleep symptoms predict the development of the metabolic syndrome. Sleep. 2010;33(12):1633–40. PMID: 21120125; https://doi.org/10.1093/sleep/33.12.1633.
Lao XQ, Liu X, Deng HB, et al. Sleep quality, sleep duration, and the risk of coronary heart disease: a prospective cohort study with 60,586 adults. J Clin Sleep Med. 2018;14(1):109–17. PMID: 29198294; https://doi.org/10.5664/jcsm.6894.
Shao M, Lin X, Jiang D, et al. Depression and cardiovascular disease: shared molecular mechanisms and clinical implications. Psychiatry Res. 2020;285:112802. PMID: 32036152; https://doi.org/10.1016/j.psychres.2020.112802.
Meng R, Yu C, Liu N, et al. Association of depression with all-cause and cardiovascular disease mortality among adults in China. JAMA Netw Open. 2020;3(2):e1921043. doi:10.1001/jamanetworkopen.2019.21043.
Chauvet-Gelinier JC, Bonin B. Stress, anxiety and depression in heart disease patients: a major challenge for cardiac rehabilitation. Ann Phys Rehabil Med. 2017;60(1):6–12. PMID: 27771272; https://doi.org/10.1016/j.rehab.2016.09.002.
Adler UC, Paiva NM, César AT, et al. Tratamento homeopático da depressão: relato de série de casos. Arch Clin Psychiatry (São Paulo). 2008;35:74–8. https://doi.org/10.1590/S0101-60832008000200005.
Zepeda-Quiroz N, Luna-Reséndiz R, Soto-Sánchez J. Efficacy of individualized homeopathy in treatment-resistant depression. cureus. 2021;13(10):e18444. PMID: 34737912; https://doi.org/10.7759/cureus.18444.
Giorgi MS, Borelli Neto L, Frias AC, Santos CMS, Trindade I. Contribuição da homeopatia no controle da ansiedade e do medo, como prevenção das emergências médicas em odontologia: estudo piloto. Rev homeopatia (São Paulo). 2010;17–22. Available from: https://pesquisa.bvsalud.org/portal/resource/pt/hom-10429.
Grimaldi-Bensouda L, Abenhaim L, Massol J; EPI3-LA-SER group. Homeopathic medical practice for anxiety and depression in primary care: the EPI3 cohort study. BMC Complement Altern Med. 2016;16:125. PMID: 27145957; https://doi.org/10.1186/s12906-016-1104-2.
Chellappa SL, Aeschbach D. Sleep and anxiety: from mechanisms to interventions. Sleep Med Rev. 2022;61:101583. PMID: 34979437; https://doi.org/10.1016/j.smrv.2021.101583.
Faisal-Cury A, Rodrigues DMO. Prevalence and associated factors with homeopathy use in Brazil: a population-based study. Cad Saude Publica. 2022;38(9):e00261821. PMID: 36169510; https://doi.org/10.1590/0102-311XEN261821.
Garcia-Cerde R, Medeiros PFP, Silva LF, et al. Use of integrative and complementary health practices by Brazilian population: results from the 2019 National Health Survey. BMC Public Health. 2023;23(1):1153. PMID: 37316825; https://doi.org/10.1186/s12889-023-16083-y.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 São Paulo Medical Journal

This work is licensed under a Creative Commons Attribution 4.0 International License.