Assessment of balance, sleep quality, and depression in relation to attention in Parkinson’s disease: A cross-sectional P300 study
Keywords:
Attention, Cognition, Parkinson Disease, Postural Balance, Neurologic Rehabilitation, Physiotherapy and Rehabilitation, Balance Impairment, Sleep Disturbances, Cognitive Processing SpeedAbstract
BACKGROUND: Parkinson’s disease (PD) is a progressive neurodegenerative disease characterized by motor and non-motor symptoms. Attention deficits are common in patients with PD, and balance can be affected by sleep quality and depression. The auditory event-related potential (ERP) P300 tool is associated with attention and discrimination processes and is a sensitive indicator of attention.
OBJECTIVES: This study aimed to investigate the effects of balance, sleep quality, and depression on attention in individuals with PD using P300 latency.
DESIGN AND SETTING: In this cross-sectional study, 28 individuals with PD and 27 healthy controls were assessed.
METHODS: Attention was measured using the auditory ERP P300, balance with the Berg Balance Scale (BBS), sleep quality with the Pittsburgh Sleep Quality Index (PSQI), and depression with the Beck Depression Inventory (BDI). Multiple linear regression analysis was used to examine the effects of these variables on P300 latency.
RESULTS: Significant differences were found between the groups in terms of attention, balance, sleep quality, and depression (all P < 0.001). Regression analysis indicated that balance (B = -4.909, P = 0.001) and sleep quality (B = 12.704, P = 0.007) were significantly associated with P300 latency, whereas depression (B = 3.472, P = 0.084) was not.
CONCLUSION: PD is associated with impaired attention, balance deficits, poor sleep quality, and increased depressive symptoms. The significant association between balance performance and sleep quality with attentional processing highlights their potential relevance in clinical assessment and management.
CLINICAL TRIAL REGISTRATION: The study was registered with Clinical Trials (NCT04687371 – https://clinicaltrials.gov/study/NCT04687371).
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Copyright (c) 2026 Gulfem Ezgi Ozaltin, Agit Simsek, Busra Candiri, Fatma Ebru Algul, Mehmet Tecellioglu, Burcu Talu
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