Cross-sectional evaluation of the saccharin transit time test for primary ciliary dyskinesia

did we discard this tool too soon?

Authors

Keywords:

Ciliary motility disorders, Microscopy, electron, transmission, Nasal mucosa, Saccharin, Bronchiectasis

Abstract

BACKGROUND: Primary ciliary dyskinesia (PCD) is a rare and heterogeneous disease that is difficult to diagnose and requires complex and expensive diagnostic tools. The saccharin transit time test is a simple and inexpensive tool that may assist in screening patients with PCD. OBJECTIVES: This study aimed to compare changes in the electron microscopy findings with clinical variables and saccharin tests in individuals diagnosed with clinical PCD (cPCD) and a control group. DESIGN AND SETTING: An observational cross-sectional study was conducted in an otorhinolaryngology outpatient clinic from August 2012 to April 2021. METHOD: Patients with cPCD underwent clinical screening questionnaires, nasal endoscopy, the saccharin transit time test, and nasal biopsy for transmission electron microscopy. RESULTS: Thirty-four patients with cPCD were evaluated. The most prevalent clinical comorbidities in the cPCD group were recurrent pneumonia, bronchiectasis, and chronic rhinosinusitis. Electron microscopy confirmed the clinical diagnosis of PCD in 16 of the 34 (47.1%) patients. CONCLUSION: The saccharin test could assist in screening patients with PCD due to its association with clinical alterations related to PCD.

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Author Biographies

Mariana Dalbo Contrera Toro, Department of Otolaryngology, Faculty of Medical Sciences, Universidade Estadual de Campinas

MD, MSc. PhD Student, Department of Otolaryngology, Faculty of Medical Sciences, Universidade Estadual de Campinas (UNICAMP), Campinas (SP), Brazil.

Erica Ortiz, Department of Otolaryngology, Faculty of Medical Sciences, Universidade Estadual de Campinas

MD, PhD. Physician, Department of Otolaryngology, Faculty of Medical Sciences, Universidade Estadual de Campinas (UNICAMP), Campinas (SP), Brazil.

Fernando Augusto Lima Marson, Department of Otolaryngology, Faculty of Medical Sciences, Universidade Estadual de Campinas

MD, PhD. Physician, Department of Pediatrics, Faculty of Medical Sciences, Universidade Estadual de Campinas (UNICAMP), Campinas (SP), Brazil; Researcher, Laboratory of Medical Genetics and Genome Medicine, Department of Medical Genetics, Faculty of Medical Sciences, UNICAMP, Campinas (SP), Brazil; Professor, Laboratory of Human and Medical Genetics, Universidade São Francisco, Bragança Paulista (SP), Brazil.

Laíza Mohana Pinheiro, Department of Otolaryngology, Faculty of Medical Sciences, Universidade Estadual de Campinas

MD. Physician, Department of Otolaryngology, Faculty of Medical Sciences, Universidade Estadual de Campinas (UNICAMP), Campinas (SP), Brazil.

Adyléia Aparecida Dalbo Contrera Toro, Department of Otolaryngology, Faculty of Medical Sciences, Universidade Estadual de Campinas

MD, PhD. Adjunct Professor, Department of Pediatrics, Faculty of Medical Sciences, Universidade Estadual de Campinas (UNICAMP), Campinas (SP), Brazil.

José Dirceu Ribeiro, Department of Otolaryngology, Faculty of Medical Sciences, Universidade Estadual de Campinas

MD, PhD. Pediatric Pulmonologist and Full Professor, Department of Pediatrics, Faculty of Medical Sciences, Universidade Estadual de Campinas (UNICAMP), Campinas (SP), Brazil

Eulália Sakano, Department of Otolaryngology, Faculty of Medical Sciences, Universidade Estadual de Campinas

MD, PhD. Adjunct Professor, Department of Otolaryngology, Faculty of Medical Sciences, Universidade Estadual de Campinas (UNICAMP), Campinas (SP), Brazil.

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Published

2023-10-05

How to Cite

1.
Toro MDC, Ortiz E, Marson FAL, Pinheiro LM, Toro AADC, Ribeiro JD, Sakano E. Cross-sectional evaluation of the saccharin transit time test for primary ciliary dyskinesia: did we discard this tool too soon?. Sao Paulo Med J [Internet]. 2023 Oct. 5 [cited 2024 Nov. 21];141(6):1-6. Available from: https://periodicosapm.emnuvens.com.br/spmj/article/view/354

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Vol. 141 No. 6 (2023)

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Original Article

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