Ultrasound techniques for the detection of developmental dysplasia of the hip

a systematic review and meta-analysis

Authors

Keywords:

Hip dislocation, congenital, Ultrasonography, Hip joint, Infant, newborn, Developmental dysplasia of the hip

Abstract

BACKGROUND: Developmental dysplasia of the hip (DDH) encompasses a broad spectrum of hip pathologies, including femoral or acetabular dysplasia, hip instability, or both. According to the medical literature, ultrasonography is the most reliable diagnostic method for DDH. Several techniques for the assessment of hips in newborns and infants, using ultrasonography, have been described. OBJECTIVE: To compare the accuracy of the Graf technique and other diagnostic techniques for DDH. DESIGN AND SETTING: A systematic review of studies that analyzed ultrasound techniques for the diagnosis of DDH within an evidence-based health program of a federal university in São Paulo (SP), Brazil. METHODS: A systematic search of relevant literature was conducted in the PubMed, EMBASE, Cochrane Library, CINAHL, and LILACS databases for articles published up to May 5, 2020, relating to studies evaluating the diagnostic accuracy of different ultrasound techniques for diagnosing DDH. The QUADAS 2 tool was used for methodological quality evaluation. RESULTS: All hips were analyzed using the Graf method as a reference standard. The Morin technique had the highest rate of sensitivity, at 81.12–89.47%. The Suzuki and Stress tests showed 100% specificity. The Harcke technique showed a sensibility of 18.21% and specificity of 99.32%. CONCLUSION: All the techniques demonstrated at least one rate (sensibility and specificity) lower than 90.00% when compared to the Graf method. The Morin technique, as evaluated in this systematic review, is recommended after the Graf method because it has the highest sensitivity, especially with the three-pattern classification of 89.47%. REGISTRATION NUMBER: Identifier: CRD42020189686 at the International Prospective Register of Systematic Reviews (identifier: CRD42020189686).

Downloads

Download data is not yet available.

Author Biographies

Marcio Luís Duarte, Evidence-Based Health Department, Universidade Federal de São Paulo

MD, MSc. Musculoskeletal Radiologist, WEBIMAGEM Telerradiologia, São Paulo (SP), Brazil. Doctoral student in Evidence-based Health Program, Universidade Federal de São Paulo (UNIFESP), São Paulo (SP), Brazil.

Giovanna Galvão Braga Motta, Evidence-Based Health Department, Universidade Federal de São Paulo

MD, MSc. Radiologist, Centro de Aperfeiçoamento e Pesquisa em Ultrassonografia Prof. Dr. Giovanni Guido Cerri (DASA), Ultrasonography, São Paulo, Brazil. Doctoral Student in Evidence-based Health Program, Universidade Federal de São Paulo (UNIFESP), São Paulo (SP), Brazil.

Natasha Vogel Majewski Rodrigues, Evidence-Based Health Department, Universidade Federal de São Paulo

MD, MSc. Pediatric Orthopedist, Hospital do Servidor Público Municipal, Pediatric orthopedics, São Paulo (SP), Brazil.

Alessandra Rodrigues Silva Chiovatto, Evidence-Based Health Department, Universidade Federal de São Paulo

MD. Radiologist, Centro de Aperfeiçoamento e Pesquisa em Ultrassonografia Prof. Dr. Giovanni Guido Cerri (DASA), Ultrasonography, São Paulo (SP), Brazil. Brazil.

Eduardo Davino Chiovatto, Evidence-Based Health Department, Universidade Federal de São Paulo

MD. Radiologist, Centro de Aperfeiçoamento e Pesquisa em Ultrassonografia Prof. Dr. Giovanni Guido Cerri (DASA), Ultrasonography, São Paulo (SP), Brazil. Brazil.

Wagner Iared, Evidence-Based Health Department, Universidade Federal de São Paulo

MD, PhD. Radiologist and Supervisor Professor, Evidence-Based Health Postgraduate Program, Universidade Federal de São Paulo (UNIFESP), São Paulo (SP), Brazil.

References

Arti H, Mehdinasab SA, Arti S. Comparing results of clinical versus ultrasonographic examination in developmental dysplasia of hip. J Res Med Sci. 2013;18(12):1051-5. PMID: 24523795.

Rosendahl K, Dezateux C, Fosse KR, et al. Immediate treatment versus sonographic surveillance for mild hip dysplasia in newborns. Pediatrics. 2010 Jan;125(1):e9-16. PMID: 20026501; https://doi.org/10.1542/peds.2009-0357.

Simon EA, Saur F, Buerge M, et al. Inter-observer agreement of ultrasonographic measurement of alpha and beta angles and the final type classification based on the Graf method. Swiss Med Wkly. 2004;134(45-46):671-7. PMID: 15611889.

Charlton S, Muir L, Skinner TC, Walters L. Pilot evaluation of anterior dynamic ultrasound screening for developmental dysplasia of the hip in an Australian regional hospital. Rural Remote Health. 2012;12:2091. PMID: 22985098.

Shipman SA, Helfand M, Moyer VA, Yawn BP. Screening for developmental dysplasia of the hip: a systematic literature review for the US Preventive Services Task Force. Pediatrics. 2006;117(3):e557-76. PMID: 16510634; https://doi.org/10.1542/peds.2005-1597.

Rosendahl K, Toma P. Ultrasound in the diagnosis of developmental dysplasia of the hip in newborns. The European approach. A review of methods, accuracy and clinical validity. Eur Radiol. 2007;17(8):1960-7. PMID: 17235535; https://doi.org/10.1007/s00330-006-0557-y.

Biedermann R, Riccabona J, Giesinger JM, et al. Results of universal ultrasound screening for developmental dysplasia of the hip: a prospective follow-up of 28 092 consecutive infants. Bone Joint J. 2018;100-B(10):1399-404. PMID: 30295526; https://doi.org/10.1302/0301-620X.100B10.BJJ-2017-1539.R2.

Shorter D, Hong T, Osborn DA. Screening programmes for developmental dysplasia of the hip in newborn infants. Cochrane Database Syst Rev. 2011;2011(9):CD004595. PMID: 21901691; https://doi.org/10.1002/14651858.CD004595.pub2.

Zonoobi D, Hareendranathan A, Mostofi E, et al. Developmental Hip Dysplasia Diagnosis at Three-dimensional US: A Multicenter Study. Radiology. 2018;287(3):1003-15. PMID: 29688160; https://doi.org/10.1148/radiol.2018172592.

Jaremko JL, Mabee M, Swami VG, et al. Potential for change in US diagnosis of hip dysplasia solely caused by changes in probe orientation: patterns of alpha-angle variation revealed by using three-dimensional US. Radiology. 2014;273(3):870-8. PMID: 24964047; https://doi.org/10.1148/radiol.14140451.

Laborie LB, Engesæter IØ, Lehmann TG, et al. Screening strategies for hip dysplasia: long-term outcome of a randomized controlled trial. Pediatrics. 2013;132(3):492-501. PMID: 23958776; https://doi.org/10.1542/peds.2013-0911.

Koşar P, Ergun E, Unlübay D, Koşar U. Comparison of morphologic and dynamic US methods in examination of the newborn hip. Diagn Interv Radiol. 2009;15(4):284-9. PMID: 19908181; https://doi.org/10.4261/1305-3825.DIR.2557-09.2.

Omeroğlu H, Biçimoğlu A, Koparal S, Seber S. Assessment of variations in the measurement of hip ultrasonography by the Graf method in developmental dysplasia of the hip. J Pediatr Orthop B. 2001;10(2):89-95. PMID: 11360786.

Diaz A, Cuervo M, Epeldegui T. Simultaneous Ultrasound Studies of Developmental Dysplasia of the Hip Using the Graf, Harcke, and Suzuki Approaches. J Pediatr Orthop B. 1993;3(2):185-9. Available from: https://journals.lww.com/jpo-b/Abstract/1994/03020/Simultaneous_Ultrasound_Studies_of_Developmental.11.aspx. Accessed in 2022 (Jul 12).

Synder M, Harcke HT, Domzalski M. Role of ultrasound in the diagnosis and management of developmental dysplasia of the hip: an international perspective. Orthop Clin North Am. 2006;37(2):141-7, v. PMID: 16638445; https://doi.org/10.1016/j.ocl.2005.11.002.

Woolacott NF, Puhan MA, Steurer J, Kleijnen J. Ultrasonography in screening for developmental dysplasia of the hip in newborns: systematic review. BMJ. 2005;330(7505):1413. PMID: 15930025; https://doi.org/10.1136/bmj.38450.646088.E0.

Omeroğlu H. Use of ultrasonography in developmental dysplasia of the hip. J Child Orthop. 2014;8(2):105-13. PMID: 24510434; https://doi.org/10.1007/s11832-014-0561-8.

Peled E, Bialik V, Katzman A, Eidelman M, Norman D. Treatment of Graf’s ultrasound class III and IV hips using Pavlik’s method. Clin Orthop Relat Res. 2008;466(4):825-9. PMID: 18288557; https://doi.org/10.1007/s11999-008-0119-5.

Lehmann HP, Hinton R, Morello P, Santoli J. Developmental dysplasia of the hip practice guideline: technical report. Committee on Quality Improvement, and Subcommittee on Developmental Dysplasia of the Hip. Pediatrics. 2000;105(4):E57. PMID: 10742378; https://doi.org/10.1542/peds.105.4.e57.

Gerscovich EO. A radiologist’s guide to the imaging in the diagnosis and treatment of developmental dysplasia of the hip. II. Ultrasonography: anatomy, technique, acetabular angle measurements, acetabular coverage of femoral head, acetabular cartilage thickness, three-dimensional technique, screening of newborns, study of older children. Skeletal Radiol. 1997;26(8):447-56. PMID: 9297748; https://doi.org/10.1007/s002560050265.

Harcke HT. Screening newborns for developmental dysplasia of the hip: the role of sonography. AJR Am J Roentgenol. 1994;162(2):395-7. PMID: 8310933; https://doi.org/10.2214/ajr.162.2.8310933.

Roposch A, Moreau NM, Uleryk E, Doria AS. Developmental dysplasia of the hip: quality of reporting of diagnostic accuracy for US. Radiology. 2006;241(3):854-60. PMID: 17053199; https://doi.org/10.1148/radiol.2413051358.

Harcke HT, Grissom LE. Infant hip sonography: current concepts. Semin Ultrasound CT MR. 1994;15(4):256-63. PMID: 7946476; https://doi.org/10.1016/s0887-2171(05)80085-x.

Harcke HT, Clarke NM, Lee MS, Borns PF, MacEwen GD. Examination of the infant hip with real-time ultrasonography. J Ultrasound Med. 1984;3(3):131-7. PMID: 6726860; https://doi.org/10.7863/jum.1984.3.3.131.

Graf R. The diagnosis of congenital hip-joint dislocation by the ultrasonic Combound treatment. Arch Orthop Trauma Surg (1978). 1980;97(2):117-33. PMID: 7458597; https://doi.org/10.1007/BF00450934.

Terjesen T, Bredland T, Berg V. Ultrasound for hip assessment in the newborn. J Bone Joint Surg Br. 1989;71(5):767-73. PMID: 2684989; https://doi.org/10.1302/0301-620X.71B5.2684989.

Czubak J, Kotwicki T, Ponitek T, Skrzypek H. Ultrasound measurements of the newborn hip. Comparison of two methods in 657 newborns. Acta Orthop Scand. 1998;69(1):21-4. PMID: 9524511; https://doi.org/10.3109/17453679809002349.

Falliner A, Schwinzer D, Hahne HJ, Hedderich J, Hassenpflug J. Comparing ultrasound measurements of neonatal hips using the methods of Graf and Terjesen. J Bone Joint Surg Br. 2006;88(1):104-6. PMID: 16365130; https://doi.org/10.1302/0301-620X.88B1.16419.

Macaskill P, Gatsonis C, Deeks J, Harbord R, Takwoingi Y. Cochrane handbook for systematic reviews of diagnostic test accuracy. Version 09 0. London: The Cochrane Collaboration; 2010.

Moher D, Liberati A, Tetzlaff J, Altman DG; PRISMA Group. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med. 2009;6(7):e1000097. PMID: 19621072; https://doi.org/10.1371/journal.pmed.1000097.

Ouzzani M, Hammady H, Fedorowicz Z, Elmagarmid A. Rayyan-a web and mobile app for systematic reviews. Syst Rev. 2016;5(1):210. PMID: 27919275; https://doi.org/10.1186/s13643-016-0384-4.

Whiting PF, Rutjes AWS, Westwood ME, et al. QUADAS-2: a revised tool for the quality assessment of diagnostic accuracy studies. Ann Intern Med. 2011;155(8):529-36. PMID: 22007046; https://doi.org/10.7326/0003-4819-155-8-201110180-00009.

Pillai A, Joseph J, McAuley A, Bramley D. Diagnostic accuracy of static graf technique of ultrasound evaluation of infant hips for developmental dysplasia. Arch Orthop Trauma Surg. 2011;131(1):53-8. PMID: 20379825; https://doi.org/10.1007/s00402-010-1100-9.

American Institute of Ultrasound in Medicine. AIUM practice guideline for the performance of an ultrasound examination for detection and assessment of developmental dysplasia of the hip. J Ultrasound Med. 2013;32(7):1307-17. PMID: 23804356; https://doi.org/10.7863/ultra.32.7.1307.

Graf R. Hip sonography: background; technique and common mistakes; results; debate and politics; challenges. Hip Int. 2017;27(3):215-9. PMID: 28497455; https://doi.org/10.5301/hipint.5000514.

Graf R. Hip Sonography Diagnosis and Management of Infant Hip Dysplasia. 2nd ed. Berlin, Heidelberg: Springer Berlin Heidelberg; 2006.

Irha E, Vrdoljak J, Vrdoljak O. Evaluation of ultrasonographic angle and linear parameters in the diagnosis of developmental dysplasia of the hip. J Pediatr Orthop B. 2004;13(1):9-14. PMID: 15091252; https://doi.org/10.1097/00009957-200401000-00002.

Diaz A, Abril JC, Cuervo M. Hüftscreening bei Kindern. Ein Vergleich verschiedener sonographischer Methoden [Hip screening in children. Comparison of various ultrasonographic methods]. Z Orthop Ihre Grenzgeb. 1995;133(6):539-42. PMID: 8571657; https://doi.org/10.1055/s-2008-1039936.

Peterlein CD, Schüttler KF, Lakemeier S, et al. Reproducibility of different screening classifications in ultrasonography of the newborn hip. BMC Pediatr. 2010;10:98. PMID: 21184670; https://doi.org/10.1186/1471-2431-10-98.

Tréguier C, Chapuis M, Branger B, et al. Pubo-femoral distance: an easy sonographic screening test to avoid late diagnosis of developmental dysplasia of the hip. Eur Radiol. 2013;23(3):836-44. PMID: 23080071; https://doi.org/10.1007/s00330-012-2635-7.

Finnbogason T, Jorulf H, Söderman E, Rehnberg L. Anterior dynamic ultrasound and Graf’s examination in neonatal hip instability. Acta Radiol. 2008;49(2):204-11. PMID: 18300148; https://doi. org/10.1080/02841850701775022.

Finnbogason T, Jorulf H. Dynamic ultrasonography of the infant hip with suspected instability. A new technique. Acta Radiol. 1997;38(2):206-9. PMID: 9093152; https://doi.org/10.1080/02841859709172050.

Poul J, Garvie D, Grahame R, Saunders AJ. Ultrasound examination of neonate’s hip joints. J Pediatr Orthop B. 1998;7(1):59-61. PMID: 9481659; https://doi.org/10.1097/01202412-199801000-00010.

Rosendahl K, Markestad T, Lie RT. Ultrasound in the early diagnosis of congenital dislocation of the hip: the significance of hip stability versus acetabular morphology. Pediatr Radiol. 1992;22(6):430-3. PMID: 1437367; https://doi.org/10.1007/BF02013504.

Gunay C, Atalar H, Dogruel H, et al. Correlation of femoral head coverage and Graf alpha angle in infants being screened for developmental dysplasia of the hip. Int Orthop. 2009;33(3):761-4. PMID: 18493759; https://doi.org/10.1007/s00264-008-0570-7.

Teixeira SR, Dalto VF, Maranho DA, et al. Comparison between Graf method and pubo-femoral distance in neutral and flexion positions to diagnose developmental dysplasia of the hip. Eur J Radiol. 2015;84(2):301-6. PMID: 25476594; doi: https://doi.org/10.1016/j.ejrad.2014.11.003.

Motta GGB, Chiovatto ARS, Chiovatto ED, et al. Measurement of Pubofemoral Distance in the Diagnosis of Developmental Dysplasia of the Hip: Sensitivity and Specificity. J Ultrasound Med. 2022;41(5):1205-12. PMID: 34405425; https://doi.org/10.1002/jum.15811.

Koşar P, Ergun E, Yiğit H, Gökharman FD, Kosar U. Developmental dysplasia in male infants: risk factors, instability and ultrasound screening. Hip Int. 2011;21(4):409-14. PMID: 21818740; https://doi.org/10.5301/HIP.2011.8577.

Clinical practice guideline: early detection of developmental dysplasia of the hip. Committee on Quality Improvement, Subcommittee on Developmental Dysplasia of the Hip. American Academy of Pediatrics. Pediatrics. 2000;105(4 Pt 1):896-905. PMID: 10742345; https://doi.org/10.1542/peds.105.4.896.

Roovers EA, Boere-Boonekamp MM, Geertsma TS, Zielhuis GA, Kerkhoff AH. Ultrasonographic screening for developmental dysplasia of the hip in infants. Reproducibility of assessments made by radiographers. J Bone Joint Surg Br. 2003;85(5):726-30. PMID: 12892198.

Downloads

Published

2023-03-02

How to Cite

1.
Duarte ML, Motta GGB, Rodrigues NVM, Chiovatto ARS, Chiovatto ED, Iared W. Ultrasound techniques for the detection of developmental dysplasia of the hip: a systematic review and meta-analysis. Sao Paulo Med J [Internet]. 2023 Mar. 2 [cited 2025 Mar. 11];141(2):154-67. Available from: https://periodicosapm.emnuvens.com.br/spmj/article/view/396

Issue

Section

Original Article