Molecular aspects of COVID-19 and its relationship with obesity and physical activity

a narrative review

Autores

Palavras-chave:

Obesity, COVID-19, Inflammation, Metabolism, SARS-CoV-2

Resumo

BACKGROUND: Severe acute respiratory syndrome coronavirus 2 has several mechanisms of action related to inflammatory responses, especially in individuals diagnosed with obesity. This hyperinflammatory clinical profile resulting from the association between obesity and coronavirus disease 2019 (COVID-19) may be attenuated by regular physical activity. OBJECTIVE: The aim of this study was to review the evidence on the consequences of physical inactivity and physical activity on COVID-19 in patients with obesity. DESIGN AND SETTING: Narrative review at the Bahiana School of Medicine and Public Health in Salvador, Brazil. METHODS: We searched evidence on the association of COVID-19 with physical activity and obesity using the following keywords: “covid-19,” “physical activity,” and “obesity”. The databases used were MEDLINE (PubMed), ScienceDirect, and Virtual Health Library. Studies published from 2019 to 2021 and available in Portuguese, English, and Spanish were included. The final search was conducted on September 26, 2021. RESULTS: We identified 661 studies in the database, among which 71 were considered for inclusion in the narrative review of the molecular aspects of COVID-19 and its relationship with physical activity and obesity. CONCLUSION: This literature review enabled the perception of the relationship between the molecular mechanisms of COVID-19 and obesity. Regular physical activity had various benefits for the inflammatory condition of the studied population, highlighting moderate-intensity.

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Biografia do Autor

Ramon de Souza Lino, Escola Bahiana de Medicina e Saúde Pública

BSc. Physical Education Professional, Research Group on Metabolic Diseases, Physical Exercise and Health Technologies, Escola Bahiana de Medicina e Saúde Pública (EBMSP), Salvador (BA), Brazil.

Mariana Sousa de Pina Silva, Escola Bahiana de Medicina e Saúde Pública

Undergraduate Student, Research Group on Metabolic Diseases, Physical Exercise, and Health Technologies, Escola Bahiana de Medicina e Saúde Pública (EBMSP), Salvador (BA), Brazil.

Daniel Simões de Jesus, Escola Bahiana de Medicina e Saúde Pública

PhD. Assistant Professor, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.

Rodrigo Colares de Macedo, Escola Bahiana de Medicina e Saúde Pública

Undergraduate Student, Research Group on Metabolic Diseases, Physical Exercise and Health Technologies, Escola Bahiana de Medicina e Saúde Pública (EBMSP), Salvador (BA), Brazil.

Laura Souza Lagares, Escola Bahiana de Medicina e Saúde Pública

BSc. Physical Education Professional, Research Group on Metabolic Diseases, Physical Exercise and Health Technologies, Escola Bahiana de Medicina e Saúde Pública (EBMSP), Salvador (BA), Brazil.

Felipe Nunes Almeida dos Santos, Escola Bahiana de Medicina e Saúde Pública

BSc. Physical Education Professional, Research Group on Metabolic Diseases, Physical Exercise and Health Technologies, Escola Bahiana de Medicina e Saúde Pública (EBMSP), Salvador (BA), Brazil.

Luiz Alberto Bastos de Almeida, Escola Bahiana de Medicina e Saúde Pública

MSc. Assistant Professor, Laboratory of Physical Activity, Universidade Estadual de Feira de Santana (UEFS), Feira de Santana (BA), Brazil.

Eric Simas Bomfim, Escola Bahiana de Medicina e Saúde Pública

BSc. Physical Education Professional, Research Group on Metabolic Diseases, Physical Exercise and Health Technologies, Escola Bahiana de Medicina e Saúde Pública (EBMSP), Salvador (BA), Brazil; Physical Education Professional, Department of Physical Education, Obesity Treatment and Surgery Center, Salvador (BA), Brazil.

Clarcson Plácido Conceição dos Santos, Escola Bahiana de Medicina e Saúde Pública

PhD. Assistant Professor, Research Group on Metabolic Diseases, Physical Exercise and Health Technologies, Escola Bahiana de Medicina e Saúde Pública (EBMSP), Salvador (BA), Brazil.

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2023-01-05

Como Citar

1.
Lino R de S, Silva MS de P, Jesus DS de, Macedo RC de, Lagares LS, Santos FNA dos, Almeida LAB de, Bomfim ES, Santos CPC dos. Molecular aspects of COVID-19 and its relationship with obesity and physical activity: a narrative review. Sao Paulo Med J [Internet]. 5º de janeiro de 2023 [citado 15º de outubro de 2025];141(1):78-86. Disponível em: https://periodicosapm.emnuvens.com.br/spmj/article/view/430

Edição

v. 141 n. 1 (2023)

Seção

Revisão Narrativa

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Creative Commons License
Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.