Colonization of methicillin-resistant Staphylococcus aureus among healthcare students
an integrative review
Keywords:
Students, health occupations, Methicillin resistance, Methicillin-resistant Staphylococcus aureus, Staphylococcus aureus, StudentsAbstract
BACKGROUND: Methicillin-resistant Staphylococcus aureus (MRSA) infection is a worldwide concern given its presence even in non-hospitalized healthy individuals, such as university students OBJECTIVE: To identify in the literature the prevalence of colonization by MRSA among healthcare students. DESIGN AND SETTING: Integrative review of the literature conducted in Universidade Federal do Piauí. METHOD: A search for primary studies was performed in the following databases: Medical Literature Analysis and Retrieval System on-line; Cumulative Index to Nursing and Allied Health Literature; Web of Science; Scopus; and LILACS. RESULTS: This review included 27 studies that demonstrated MRSA infection prevalence ranging from 0.0 to 15.3% among students. CONCLUSION: The prevalence of colonization of MRSA among healthcare students is high, and the nasal cavity was cited as an important reservoir location for these microorganisms.
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Carvalho MS, Andrade DF, Sousa ÁF, et al. Nasal colonization with Staphylococcus aureus in nursing students: ground for monitoring. Rev Bras Enferm. 2016;69(6):1046-51. PMID: 27925079; https://doi.org/10.1590/0034-7167-2016-0210
Abulkasim GS, Shukla HK, Masih H. Antimicrobial resistance of staphylococcus aureus among healthy and adult students. Int J Pharm Sci Res. 2017;8(12):5247-51. Available from: https://ijpsr.com/bft-article/antimicrobial-resistance-of-staphylococcus-aureus-among-healthy-and-adult-students/?view=fulltext Accessed in 2021 (May 10).
Hogan B, Rakotozandrindrainy R, Al-Emran H, et al. Prevalence of nasal colonisation by methicillin-sensitive and methicillin-resistant Staphylococcus aureus among healthcare workers and students in Madagascar. BMC Infect Dis. 016;16(1):420. PMID: 27526771; https://doi.org/10.1186/s12879-016-1733-6
Almeida GCM, Lima NG, Santos MM, Melo MCN, Lima KC. Colonização nasal por Staphylococcus sp em pacientes internados. Acta Paul Enferm. 2014;27(3):273-9. https://doi.org/10.1590/1982-0194201400046
Efa F, Alemu Y, Beyene G, Gudina EK, Kebede W. Methicillin-resistant Staphylococcus aureus carriage among medical students of Jimma University, Southwest Ethiopia. Heliyon. 2019;5(1):e01191. PMID: 30775580; https://doi.org/10.1016/j.heliyon.2019.e01191
Moremi N, Claus H, Vogel U, Mshana SE. The role of patients and healthcare workers Staphylococcus aureus nasal colonization in occurrence of surgical site infection among patients admitted in two centers in Tanzania. Antimicrob Resist Infect Control. 2019;8:102. PMID: 31236269; https://doi.org/10.1186/s13756-019-0554-y
Abroo S, Hosseini Jazani N, Sharifi Y. Methicillin-resistant Staphylococcus aureus nasal carriage between healthy students of medical and nonmedical universities. Am J Infect Control. 2017;45(7):709-12. PMID: 28359610; https://doi.org/10.1016/j.ajic.2017.02.034
Galvão CM, Mendes KDS, Silveira RCCP. Revisão integrativa: método de revisão para sintetizar as evidências disponíveis na literatura. In: Brevidelli MM, Sertório SCM, editors. Trabalho de conclusão de curso: guia prático para docentes e alunos da área da saúde. São Paulo: Iátria; 2010. p. 105-26.
Moher D, Liberati A, Tetzlaff J, Altman DG; PRISMA Group. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med. 2009;6(7):e1000097. PMID: 19621072; https://doi.org/10.1371/journal.pmed.1000097
Ursi ES, Gavão CM. Prevenção de lesões de pele no perioperatório: revisão integrativa da literatura [Perioperative prevention of skin injury: an integrative literature review]. Rev Lat Am Enfermagem. 2006;14(1):124-31. PMID: 16532249; https://doi.org/10.1590/s0104-11692006000100017
Prates KA, Torres AM, Garcia LB, et al. Nasal carriage of methicillin-resistant Staphylococcus aureus in university students. Braz J Infect Dis. 2010;14(3):316-8. PMID: 20835520.
Syafinaz AM, Nur Ain NZ, Nadzirahi SN, et al. Staphylococcus aureus Nasal Carriers Among Medical Students in A Medical School. Med J Malaysia. 2012;67(6):636-8. PMID: 23770966.
Bettin A, Causil C, Reyes N. Molecular identification and antimicrobial susceptibility of Staphylococcus aureus nasal isolates from medical students in Cartagena, Colombia. Braz J Infect Dis. 2012;16(4):329-34. PMID: 22846119; https://doi.org/10.1016/j.bjid.2012.06.017
Chen CS, Chen CY, Huang YC. Nasal carriage rate and molecular epidemiology of methicillin-resistant Staphylococcus aureus among medical students at a Taiwanese university. Int J Infect Dis. 2012;16(11):e799-803. PMID: 2287817; https://doi.org/10.1016/j.ijid.2012.07.004
López-Aguilera S, Goñi-Yeste M del M, Barrado L, et al. Colonización nasal por Staphylococcus aureus en estudiantes de medicina: importancia en la transmisión hospitalaria [Staphylococcus aureus nasal colonization in medical students: importance in nosocomial transmission]. Enferm Infecc Microbiol Clin. 2013;31(8):500-5. PMID: 23352260; https://doi.org/10.1016/j.eimc.2012.12.005
Sabri I, Adwan K, Essawi TA, Farraj MA. Molecular characterization of methicillin-resistant Staphylococcus aureus isolates in three different Arab world countries. Eur J Microbiol Immunol (Bp). 2013;3(3):183-7. PMID: 24265936; https://doi.org/10.1556/EuJMI.3.2013.3.5
Mat Azis N, Hamid AAB, Pung HP, et al. Staphylococcus aureus infection risk in a population of health sciences students at a public university. Iranian J Publ Health 2014;43(Suppl 12):112-6. Available from: https://ijph.tums.ac.ir/index.php/ijph/article/view/4887 Accessed in 2021 (May 10).
Malik NFA, Muharram SH, Abiola O. Staphylococcus aureus nasal carriage in young healthy adults in Brunei Darussalam. Brunei Int Med J. 2014;10(2):78-84.
Krishnamurthy V, Saha A, Renushri BV, Nagaraj ER. Methicillin Resistant Staphylococcus aureus Carriage, Antibiotic Resistance and Molecular Pathogenicity among Healthy Individuals Exposed and Not Exposed to Hospital Environment. J Clin Diagn Res. 2014;8(7):DC04-8. PMID: 25177563; https://doi.org/10.7860/JCDR/2014/8409.4638
Demirel G, Findik D, Dagi HT, Arslan U. Community-acquired methicillin-resistant Staphylococcus aureus and genotypes among university students in Turkey. Southeast Asian J Trop Med Public Health. 2014;45(6):1401-9. PMID: 26466426.
Renushri BV, Saha A, Nagaraj ER, et al. Screening for methicillin-resistant Staphylococcus aureus carriers among individuals exposed and not exposed to the hospital environment and their antimicrobial sensitivity pattern. Annals of Tropical Medicine and Public Health. 2014;7(1):19-24. Available from: https://cyberleninka.org/article/n/503731 Accessed in 2021 (May 10).
Ribeiro IF, Silva SFR, Silva SL, et al. Identificação de Staphylococcus aureus e Staphylococcus aureus resistente à meticilina em estudantes universitários. Rev Ciênc Farm Básica Apl. 2014;35(2):299-302. Available from: https://rcfba.fcfar.unesp.br/index.php/ojs/article/view/145/143 Accessed in 2021 (May 10).
Zakai SA. Prevalence of methicillin-resistant Staphylococcus aureus nasal colonization among medical students in Jeddah, Saudi Arabia. Saudi Med J. 2015;36(7):807-12. PMID: 26108584; https://doi.org/10.15537/smj.2015.7.11609
Holý O, Vlčková J, Matoušková I, Kolář M. Prevalence výskytu nosního nosičství kmenů Staphylococcus aureus a meticilin rezistentních kmenů S. aureus (MRSA) u studentů všeobecného lékařství LF UP v Olomouci [The prevalence of nasal carriage of Staphylococcus aureus and methicillin-resistant S. aureus (MRSA) among general medicine students of the Palacky University Olomouc]. Epidemiol Mikrobiol Imunol. 2015;64(2):98-101. PMID: 26099614.
Collazos Marín LF, Estupiñan Arciniegas G, Chavez Vivas M. Characterization of Staphylococcus aureus Isolates That Colonize Medical Students in a Hospital of the City of Cali, Colombia. Int J Microbiol. 2015;2015:358489. PMID: 26495001; https://doi.org/10.1155/2015/358489
Petti S, Kakisina N, Volgenant CM, et al. Low methicillin-resistant Staphylococcus aureus carriage rate among Italian dental students. Am J Infect Control. 2015;43(12):e89-91. PMID: 26384585; https://doi.org/10.1016/j.ajic.2015.08.008
Javaeed A, Khan S, Haqsubhani RU, Ghauri SK, Jahan S. Methicillin Resistant Staphylococcus Aureus Prevalence of Nasal Carriage among Healthy MBBS Students of Continental Medical College, Lahore. P J M H S. 2016;10(3): 1057-9. Available from: https://pjmhsonline.com/2016/july_sep/pdf/1057.pdf Accessed in 2021 (May 10).
Subri NIBM, Hlaing SS, Myint, T, et al. Nasal Carriage of Staphylococcus aureus and Its Antibiotic Susceptibility Pattern among Medical and Nursing Students. Asian J Pharm. 2016;10(4):736-40. https://dx.doi.org/10.22377/ajp.v10i04.917
Ansari S, Gautam R, Shrestha S, et al. Risk factors assessment for nasal colonization of Staphylococcus aureus and its methicillin resistant strains among pre-clinical medical students of Nepal. BMC Res Notes. 2016;9:214. PMID: 27068121; https://doi.org/10.1186/s13104-016-2021-7
Okamo B, Moremi N, Seni J, et al. Prevalence and antimicrobial susceptibility profiles of Staphylococcus aureus nasal carriage among pre-clinical and clinical medical students in a Tanzanian University. BMC Res Notes. 2016;9:47. PMID: 26817605; https://doi.org/10.1186/s13104-016-1858-0
Baek YS, Baek SH, Yoo YJ. Higher nasal carriage rate of methicillin-resistant Staphylococcus aureus among dental students who have clinical experience. J Am Dent Assoc. 2016 May;147(5):348-53. PMID: 26778005; https://doi.org/10.1016/j.adaj.2015.12.004
Radhakrishna M, Taneja A, Rao P. Nasal carriage of Staphylococcus aureus with special emphasis on methicillin-resistant Staphylococcus aureus among students of a south Indian medical college - prevalence and antibiogram pattern. Asian J Pharm Clin Res. 2016;9(8):129-32. https://doi.org/10.22159/ajpcr.2016.v9s2.13274
Budri PE, Shore AC, Coleman DC, et al. Observational cross-sectional study of nasal staphylococcal species of medical students of diverse geographical origin, prior to healthcare exposure: prevalence of SCCmec, fusC, fusB and the arginine catabolite mobile element (ACME) in the absence of selective antibiotic pressure. BMJ Open. 2018 Apr 20;8(4):e020391. PMID: 29678979; http://dx.doi.org/10.1136/bmjopen-2017-020391
Al-Tamimi M, Himsawi N, Abu-Raideh J, Jazar DA, Al-jawaldeh H, Mahmoud SAH. Nasal colonization by methicillin-sensitive and methicillin-resistant Staphylococcus aureus among medical students. J Infect Dev Ctries 2018; 12(5):326-35. https://doi.org/10.3855/jidc.9908
Suhaili Z, Rafee P’, Mat Azis N, et al. Characterization of resistance to selected antibiotics and Panton-Valentine leukocidin-positive Staphylococcus aureus in a healthy student population at a Malaysian University. Germs. 2018;8(1):21-30. PMID: 29564245; https://doi.org/10.18683/germs.2018.1129
Onanuga A, Eboh DD, Okou GT. Antibiogram and Virulence Characteristics of Multi-drug Resistant Staphylococcus aureus from Nasal Cavity of Healthy Students of Niger Delta University, Amassoma, Bayelsa State, Nigeria. Journal of Clinical and Diagnostic Research. 2019;13(7):24-9. https://doi.org/10.7860/JCDR/2019/41396.13031
Szymanek-Majchrzak K, Kosiński J, Żak K, et al. Prevalence of methicillin resistant and mupirocin-resistant Staphylococcus aureus strains among medical students of Medical University in Warsaw. Przegl Epidemiol. 2019;73(1):39-48. PMID: 31134773; https://doi.org/10.32394/pe.73.05
Centers for disease control and prevention (CDC). Healthcare-associated infections. Current HAI Progress Report. 2019 National and State Healthcare-Associated Infections Progress Report. Available from: http://www.cdc.gov/hai/progress-report/index.html Accessed in 2021 (May 10).
Rohde RE, Rowder C, Patterson T, et al. Methicillin resistant Staphylococcus aureus (MRSA): an interim report of carriage and conversion rates in nursing students. Clin Lab Sci. 2012;25(2):94-101. PMID: 22693778; https://doi.org/10.29074/ascls.25.2.94
Evangelista SS, Oliveira AC. Staphylococcus aureus meticilino resistente adquirido na comunidade: um problema mundial. Rev Bras Enferm. 2015;68(1):136-41. https://doi.org/10.1590/0034-7167.2015680119p
Conceição T, de Lencastre H, Aires-de-Sousa M. Carriage of Staphylococcus aureus among Portuguese nursing students: A longitudinal cohort study over four years of education. PLoS One. 2017;12(11):e0188855. PMID: 29190721; https://doi.org/10.1371/journal.pone.0188855
