Perfusion index: Could this be a new triage tool for upper gastrointestinal system bleeding in the emergency department? A prospective cohort study

Authors

Keywords:

Emergencies, Perfusion index, Upper gastrointestinal tract.

Abstract

BACKGROUND: Many scoring systems for predicting mortality, rebleeding and transfusion needs among patients with upper gastrointestinal bleeding (UGIB) have been developed. However, no scoring system can predict all these outcomes. OBJECTIVE: To show whether the perfusion index (PI), compared with the Rockall score (RS), helps predict transfusion needs and prognoses among patients presenting with UGIB in emergency departments. In this way, critical patients with transfusion needs can be identified at an early stage. DESIGN AND SETTING: Prospective cohort study in an emergency department in Turkey, conducted between June 2018 and June 2019. METHODS: Patients’ demographic parameters, PI, RS, transfusion needs and prognosis were recorded. RESULTS: A total of 219 patients were included. Blood transfusion was performed in 174 patients (79.4%). The PI cutoff value for prediction of the need for blood transfusion was 1.17, and the RS cutoff value was 5. The area under the curve (AUC) value for PI (AUC: 0.772; 95% confidence interval, CI: 0.705-0.838; P < 0.001) was higher than for RS (AUC: 0.648; 95% CI: 0.554-0.741; P = 0.002). 185 patients (84.5%) were discharged, and 34 patients (15.5%) died. The PI cutoff value for predicting mortality was 1.1, and the RS cutoff value was 7. The AUC value for PI (AUC: 0.743; 95% CI: 0.649-0.837; P < 0.001) was higher than for RS (AUC: 0.725; 95% CI: 0.639-0.811; P < 0.001). CONCLUSION: PI values for patients admitted to emergency departments with UGIB on admission can help predict their need for transfusion and mortality risk.

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Author Biographies

Basak Toptas Firat, Adana Şehir Eğitim ve Araştırma Hastanesi

MD. Emergency Physician, Department of Emergency Medicine, Adana City Training and Research Hospital, Adana, Turkey.

Muge Gulen, Adana Şehir Eğitim ve Araştırma Hastanesi

MD, PhD. Associate Professor, Department of Emergency Medicine, Adana City Training and Research Hospital, Adana, Turkey.

Salim Satar, Adana City Training and Research Hospital

MD, PhD. Associate Professor, Department of Emergency Medicine, Adana City Training and Research Hospital, Adana, Turkey.

Ahmet Firat, Adana Şehir Eğitim ve Araştırma Hastanesi

MD. Internal Medicine Physician, Department of Intensive Care Unit, Cukurova University School of Medicine, Adana, Turkey.

Selen Acehan, Adana Şehir Eğitim ve Araştırma Hastanesi

MD. Emergency Physician, Department of Emergency Medicine, Adana City Training and Research Hospital, Adana, Turkey.

Cem Isikber, Adana Şehir Eğitim ve Araştırma Hastanesi

MD. Emergency Physician, Department of Emergency Medicine, Adana City Training and Research Hospital, Adana, Turkey.

Adem Kaya, Adana Şehir Eğitim ve Araştırma Hastanesi

MD. Emergency Physician, Department of Emergency Medicine, Adana City Training and Research Hospital, Adana, Turkey.

Gonca Koksaldi Sahin, Adana Şehir Eğitim ve Araştırma Hastanesi

MD. Emergency Physician, Department of Emergency Medicine, Adana City Training and Research Hospital, Adana, Turkey.

Haldun Akoglu, Adana Şehir Eğitim ve Araştırma Hastanesi

MD, PhD. Professor, Department of Emergency Medicine, Marmara University School of Medicine, Istanbul, Turkey.

References

Abougergi MS, Charpentier JP, Bethea E, et al. A Prospective, Multicenter Study of the AIMS65 Score Compared With the Glasgow-Blatchford Score in Predicting Upper Gastrointestinal Hemorrhage Outcomes. J Clin Gastroenterol. 2016;50(6):464-9. PMID: 26302496; https://doi.org/10.1097/MCG.0000000000000395.

Kim MS, Choi J, Shin WC. AIMS65 scoring system is comparable to Glasgow-Blatchford score or Rockall score for prediction of clinical outcomes for non-variceal upper gastrointestinal bleeding. BMC Gastroenterol. 2019;19(1):136. PMID: 31349816; https://doi.org/10.1186/s12876-019-1051-8.

Mokhtare M, Bozorgi V, Agah S, et al. Comparison of Glasgow-Blatchford score and full Rockall score systems to predict clinical outcomes in patients with upper gastrointestinal bleeding. Clin Exp Gastroenterol. 2016;9:337-43. PMID: 27826205; https://doi.org/10.2147/CEG.S114860.

Stanley AJ, Laine L, Dalton HR, et al. Comparison of risk scoring systems for patients presenting with upper gastrointestinal bleeding: international multicentre prospective study. BMJ. 2017;356:i6432. PMID: 28053181; https://doi.org/10.1136/bmj.i6432.

Rockall TA, Logan RF, Devlin HB, Northfield TC. Risk assessment after acute upper gastrointestinal haemorrhage. Gut. 1996;38(3):316-21. PMID: 8675081; https://doi.org/10.1136/gut.38.3.316.

Rockall TA, Logan RF, Devlin HB, Northfield TC. Selection of patients for early discharge or outpatient care after acute upper gastrointestinal haemorrhage. National Audit of Acute Upper Gastrointestinal Haemorrhage. Lancet. 1996;347(9009):1138-40. PMID: 8609747; https://doi.org/10.1016/s0140-6736(96)90607-8.

Tham TC, James C, Kelly M. Predicting outcome of acute non-variceal upper gastrointestinal haemorrhage without endoscopy using the clinical Rockall Score. Postgrad Med J. 2006;82(973):757-9. PMID: 17099097 doi: 10.1136/pmj.2006.048462.

Hales JR, Stephens FR, Fawcett AA, et al. Observations on a new non-invasive monitor of skin blood flow. Clin Exp Pharmacol Physiol. 1989;16(5):403-15. PMID: 2527655; https://doi.org/10.1111/j.1440-1681.1989.tb01578.x.

Mowafi HA, Ismail SA, Shafi MA, Al-Ghamdi AA. The efficacy of perfusion index as an indicator for intravascular injection of epinephrine-containing epidural test dose in propofol-anesthetized adults. Anesth Analg. 2009;108(2):549-53. PMID: 19151286; https://doi.org/10.1213/ane.0b013e31818fc35b.

De Felice C, Latini G, Vacca P, Kopotic RJ. The pulse oximeter perfusion index as a predictor for high illness severity in neonates. Eur J Pediatr. 2002;161(10):561-2. PMID: 12297906; https://doi.org/10.1007/s00431-002-1042-5.

Lima AP, Beelen P, Bakker J. Use of a peripheral perfusion index derived from the pulse oximetry signal as a noninvasive indicator of perfusion. Crit Care Med. 2002;30(6):1210-3. PMID: 12072670; https://doi.org/10.1097/00003246-200206000-00006.

He HW, Liu DW, Long Y, Wang XT. The peripheral perfusion index and transcutaneous oxygen challenge test are predictive of mortality in septic patients after resuscitation. Crit Care. 2013;17(3):R116. PMID: 23787173; https://doi.org/10.1186/cc12788.

Hamunen K, Kontinen V, Hakala E, et al. Effect of pain on autonomic nervous system indices derived from photoplethysmography in healthy volunteers. Br J Anaesth. 2012;108(5):838-44. PMID: 22369767; https://doi.org/10.1093/bja/aes001.

Emektar E, Dagar S, Uzunosmanoglu H, et al. The role of perfusion index and plethysmography variability index for predicting dehydration severity in patients with acute gastroenteritis. Hong Kong Journal of Emergency Medicine. 2019:1-6 https://doi.org/10.1177/1024907919889488.

Ozakin E, Yazlamaz NO, Kaya FB, Karakilic EM, Bilgin M. Perfusion Index Measurement in Predicting Hypovolemic Shock in Trauma Patients. J Emerg Med. 2020;59(2):238-45. PMID: 32439257; https://doi.org/10.1016/j.jemermed.2020.04.010.

Villanueva C, Colomo A, Bosch A, et al. Transfusion strategies for acute upper gastrointestinal bleeding. N Engl J Med. 2013;368(1):11-21. PMID: 23281973; https://doi.org/10.1056/NEJMoa1211801.

de Franchis R; Baveno VI Faculty. Expanding consensus in portal hypertension: Report of the Baveno VI Consensus Workshop: Stratifying risk and individualizing care for portal hypertension. J Hepatol. 2015;63(3):743-52. PMID: 26047908; https://doi.org/10.1016/j.jhep.2015.05.022.

Lima A, Bakker J. Noninvasive monitoring of peripheral perfusion. Intensive Care Med. 2005;31(10):1316-26. PMID: 16170543; https://doi.org/10.1007/s00134-005-2790-2.

Bond RF. A review of the skin and muscle hemodynamics during hemorrhagic hypotension and shock. Adv Shock Res. 1982;8:53-70. PMID: 6753542.

Galvagno SM Jr, Nahmias JT, Young DA. Advanced Trauma Life Support® Update 2019: Management and Applications for Adults and Special Populations. Anesthesiol Clin. 2019;37(1):13-32. PMID: 30711226; https://doi.org/10.1016/j.anclin.2018.09.009.

Bailey JM, Levy JH, Kopel MA, Tobia V, Grabenkort WR. Relationship between clinical evaluation of peripheral perfusion and global hemodynamics in adults after cardiac surgery. Crit Care Med. 1990;18(12):1353-6. PMID: 2245608; https://doi.org/10.1097/00003246-199012000-00008.

van Genderen ME, Bartels SA, Lima A, et al. Peripheral perfusion index as an early predictor for central hypovolemia in awake healthy volunteers. Anesth Analg. 2013;116(2):351-6. PMID: 23302972; https://doi.org/10.1213/ANE.0b013e318274e151.

Barkun AN, Bardou M, Kuipers EJ, et al. International consensus recommendations on the management of patients with nonvariceal upper gastrointestinal bleeding. Ann Intern Med. 2010;152(2):101-13. PMID: 20083829; https://doi.org/10.73260003-4819-152-2-201001190-00009.

Chang A, Ouejiaraphant C, Akarapatima K, Rattanasupa A, Prachayakul V. Prospective Comparison of the AIMS65 Score, Glasgow-Blatchford Score, and Rockall Score for Predicting Clinical Outcomes in Patients with Variceal and Nonvariceal Upper Gastrointestinal Bleeding. Clin Endosc. 2021;54(2):211-21. PMID: 32668528; https://doi.org/10.5946/ce.2020.068.

Monteiro S, Gonçalves TC, Magalhães J, Cotter J. Upper gastrointestinal bleeding risk scores: Who, when and why? World J Gastrointest Pathophysiol. 2016;7(1):86-96. PMID: 26909231; https://doi.og/10.4291/wjgp.v7.i1.86.

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Published

2021-11-04

How to Cite

1.
Firat BT, Gulen M, Satar S, Firat A, Acehan S, Isikber C, Kaya A, Sahin GK, Akoglu H. Perfusion index: Could this be a new triage tool for upper gastrointestinal system bleeding in the emergency department? A prospective cohort study. Sao Paulo Med J [Internet]. 2021 Nov. 4 [cited 2025 Mar. 9];139(6):583-90. Available from: https://periodicosapm.emnuvens.com.br/spmj/article/view/551

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