Detection of human papillomavirus in dental biofilm and the uterine cervix of a pregnant adolescent
Keywords:
Human papillomavirus 16, Adolescent, Dental plaque, Gingivitis, Periodontitis, PregnancyAbstract
CONTEXT: Adolescence and pregnancy are considered to be risk factors for human papillomavirus (HPV) infection. The relationship between this infection in the uterine cervix and oral HPV infection is controversial. CASE REPORT: This report describes a case of a pregnant 16-year-old adolescent who presented HPV infection in the uterine cervix and the mouth. Smears were collected from the cervix and the tongue/ palate. Dental biofilm samples were also collected. The microarray technique was used to detect HPV. The HPV 56 subtype was observed in the cervical smear and HPV 6 in dental biofilm. CONCLUSION: In this pregnant adolescent, HPV infection was present in both the cervix and the mouth, but the HPV subtypes infecting these two areas were different.
Downloads
References
D’Souza G, Agrawal Y, Halpern J, Bodison S, Gillison ML. Oral sexual behaviors associated with prevalent oral human papillomavirus infection. J Infect Dis. 2009;199(9):1263-9.
Smith EM, Johnson SR, Jiang D, et al. The association between pregnancy and human papilloma virus prevalence. Cancer Detect Prev. 1991;15(5):397-402.
Insinga RP, Dasbach EJ, Elbasha EH. Epidemiologic natural history and clinical management of Human Papillomavirus (HPV) Disease: a critical and systematic review of the literature in the development of an HPV dynamic transmission model. BMC Infect Dis. 2009;9:119.
Smith EM, Ritchie JM, Yankowitz J, et al. HPV prevalence and concordance in the cervix and oral cavity of pregnant women. Infect Dis Obstet Gynecol. 2004;12(2):45-56.
Dos Reis HL, Rabelo PC, de Santana MR, Ferreira DC, Filho AC. Oral squamous papilloma and condyloma acuminatum as manifestations of buccal-genital infection by human papillomavirus. Indian J Sex Transm Dis. 2009;30(1):40-2.
Brown DR, Shew ML, Qadadri B, et al. A longitudinal study of genital human papillomavirus infection in a cohort of closely followed adolescent women. J Infect Dis. 2005;191(2):182-92.
Al-Awadhi A, Chehadeh W, Al-Jassar W, et al. Phylogenetic analysis of partial L1 gene of 10 human papillomavirus types isolated most commonly from women with normal and abnormal cervical cytology in Kuwait. Arch Virol. 2013;158(8):1687-99.
Hormia M, Willberg J, Ruokonen H, Syrjänen S. Marginal periodontium as a potential reservoir of human papillomavirus in oral mucosa. J Periodontol. 2005;76(3):358-63.
Parra B, Slots J. Detection of human viruses in periodontal pockets using polymerase chain reaction. Oral Microbiol Immunol. 1996;11(5):289-93.
Schroeder HE, Listgarten MA. The gingival tissues: the architecture of periodontal protection. Periodontol 2000. 1997;13:91-120.
Brondani M. HPV, oral sex, and the risk of oral cancer: food for thought. Spec Care Dentist. 2008;28(5):183-4.
Rintala M, Grénman S, Puranen M, Syrjänen S. Natural history of oral papillomavirus infections in spouses: a prospective Finnish HPV Family Study. J Clin Virol. 2006;35(1):89-94.
