What do Cochrane systematic reviews say about interventions for age-related macular degeneration?

Authors

Keywords:

Review [publication type], Macular degeneration, Macular degeneration, age-related, 1 [supplementary concept], Evidence-based medicine, Evidence-based practice

Abstract

BACKGROUND: Age-related macular degeneration (AMD) is the third largest cause of blindness world-wide, accounting for 8.7% of all cases. A considerable number of preventive or therapeutic interventions have been used for AMD. OBJECTIVE: This study presents a critical view of the interventions that have been assessed through Co-chrane systematic reviews. DESIGN AND SETTING: Review of systematic reviews, conducted in the Discipline of Evidence-Based Medicine, Escola Paulista de Medicina (EPM), Universidade Federal de São Paulo (UNIFESP). METHODS: Review of Cochrane systematic reviews about interventions for AMD. RESULTS: The 18 systematic reviews included assessed the effects of surgical techniques, laser/photo/ radiotherapy, intravitreal injections, systemic drugs and phytotherapy/vitamins/supplements. CONCLUSION: The Cochrane systematic reviews found evidence that use of bevacizumab, ranibizumab, pegap-tanib, laser photocoagulation, photodynamic therapy and multivitamin compounds may present some benefits for treating AMD. There was insufficient evidence for supporting the use of macular translocation, submacular surgery, steroid implantation, radiotherapy, intravitreal aflibercept, interferon alfa, statins or omega-3 fatty acids for treat-ing AMD; or the use of multivitamin antioxidant vitamins or mineral supplementation for preventing AMD. Future randomized controlled trials are imperative to reduce the uncertainty in several clinical questions regarding AMD.

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Author Biographies

Vania Mozetic, Instituto Dante Pazzanese de Cardiologia

MD. Ophthalmologist, Instituto Dante Pazzanese de Cardiologia, São Paulo (SP), Brazil

Rafael Leite Pacheco, Universidade Federal de São Paulo

MD. Researcher, Centro Universitário São Camilo, and Master’s Student, Evidence-Based Health Program, Universidade Federal de São Paulo (UNIFESP), São Paulo (SP), Brazil.

Carolina de Oliveira Cruz Latorraca, Universidade Federal de São Paulo

MSc. Psychologist and Doctoral Student, Evidence-Based Health Program, Universidade Federal de São Paulo (UNIFESP), and Assistant Researcher, Cochrane Brazil, São Paulo (SP), Brazil

Fernanda Chin Yu Lee, Universidade Federal de São Paulo

Undergraduate Medical Student, Escola Paulista de Medicina (EPM), Universidade Federal de São Paulo (UNIFESP), São Paulo (SP), Brazil

João Victor Borges Gomes, Universidade Federal de São Paulo

Undergraduate Medical Student, Escola Paulista de Medicina (EPM), Universidade Federal de São Paulo (UNIFESP), São Paulo (SP), Brazil

Rachel Riera, Hospital Sírio-Libanês

MD, MSc, PhD. Rheumatologist and Adjunct Professor, Discipline of Evidence-Based Medicine, Escola Paulista de Medicina (EPM), Universidade Federal de São Paulo (UNIFESP), and Coordinator, Centre of Health Technology Assessment, Hospital Sírio-Libanês, São Paulo (SP), Brazil.

References

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Published

2019-12-05

How to Cite

1.
Mozetic V, Pacheco RL, Latorraca C de OC, Lee FCY, Gomes JVB, Riera R. What do Cochrane systematic reviews say about interventions for age-related macular degeneration?. Sao Paulo Med J [Internet]. 2019 Dec. 5 [cited 2025 Apr. 28];137(6):530-42. Available from: https://periodicosapm.emnuvens.com.br/spmj/article/view/998

Issue

Vol. 137 No. 6 (2019)

Section

Narrative Review

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