Prevenção de tromboembolismo venoso (trombose venosa profunda e embolia pulmonar) em pacientes clínicos e cirúrgicos
Keywords:
Revisão, embolia pulmonar, trombose venosa, tromboembolia venosa, prevenção de doençasAbstract
O tromboembolismo venoso tem grande prevalência nas mais diversas áreas da medicina e está associado a altos índices de morbimortalidade. Sua profilaxia está bem estabelecida em certas situações, e muito se tem estudado a esse respeito. No entanto, a adesão dos serviços de saúde à tromboprofilaxia ainda está muito aquém do ideal. Neste artigo, abordamos os atuais métodos de tromboprofilaxia em pacientes clínicos (com especial atenção para os oncológicos) e cirúrgicos.
References
Lindblad B, Eriksson A, Bergqvist D. Autopsy-verified pulmonary embolism in a surgical department: analysis of the period from 1951 to 1988. Br J Surg. 1991;78(7):849-52.
Martino MA, Borges E, Williamson E, et al. Pulmonary embolism after major abdominal surgery in gynecologic oncology. Obstet Gynecol. 2006;107(3):666-71.
Dismuke SE, Wagner EH. Pulmonary embolism as a cause of death. The changing mortality in hospitalized patients. JAMA.1986;255(15):2039-42.
Horlander KT, Mannino DM, Leeper KV. Pulmonary embolism mortality in the United States, 1979-1998: an analysis using multiple-cause mortality data. Arch Intern Med. 2003;163(14):1711-7.
Golin V, Sprovieri SR, Bedrikow R, Salles MJ. Pulmonary thromboembolism: retrospective study of necropsies performed over 24 years in a university hospital in Brazil. Sao Paulo Med J. 2002;120(4):105-8.
Darze ES, Casqueiro JB, Ciuffo LA, Santos JM, Magalhães IR, Latado AL. Mortalidade por Embolia Pulmonar no Brasil entre 1989 e 2010: Disparidades Regionais e por Gênero [Pulmonary Embolism Mortality in Brazil from 1989 to 2010: Gender and Regional Disparities. Arq Bras Cardiol. 2016;106(1):4-12.
Geerts WH, Bergqvist D, Pineo GF, et al. Prevention of venous thromboembolism: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest. 2008;133(6 Suppl):381S-453S.
Streiff MB. Predicting the risk of recurrent venous thromboembolism (VTE). J Thromb Thrombolysis. 2015;39(3):353-66.
Dinger J, Assmann A, Möhner S, Minh TD. Risk of venous thromboembolism and the use of dienogest- and drospirenone-containing oral contraceptives: results from a German case-control study. J Fam Plann Reprod Health Care. 2010;36(3):123-9.
Heit JA, O’Fallon WM, Petterson TM, et al. Relative impact of risk factors for deep vein thrombosis and pulmonary embolism: a population-based study. Arch Intern Med. 2002;162(11):1245-8.
Prandoni P, Samama MM. Risk stratification and venous thromboprophylaxis in hospitalized medical and cancer patients. Br J Haematol. 2008;141(5):587-97.
Anderson FA Jr, Spencer FA. Risk factors for venous thromboembolism. Circulation. 2003;107(23 Suppl 1):I9-16.
Samama MM. An epidemiologic study of risk factors for deep vein thrombosis in medical outpatients: the Sirius study. Arch Intern Med. 2000;160(22):3415-20.
Cohen AT, Alikhan R, Arcelus JI, et al. Assessment of venous thromboembolism risk and the benefits of thromboprophylaxis in medical patients. Thromb Haemost. 2005;94(4):750-9.
Lee AYY, Levine MN. Venous thromboembolism and cancer: risk and outcomes. Circulation. 2003;107:I-17-I-21. Disponível em: http://circ.ahajournals.org/content/107/23_suppl_1/I-17.full. pdf+html. Acessado em 2015 (11 dez.)
Sørensen HT, Mellemkjaer L, Olsen JH, Baron JA. Prognosis of cancer associated with venous thromboembolism. N Engl J Med. 2000;343(25):1846-50.
Cohen AT, Tapson VF, Bergmann JF, et al. Venous thromboemlism risk and prophylaxis in the acute hospital care setting (ENDORSE study): a multinational cross-sectional study. Lancet. 2008;371(9610):387-94.18. Zwicker JL, Liebman HA, Neuberg D, et al. Tumor-derived tissue factorbearing microparticles are associated with venous thromboembolic events in malignancy. Clin Cancer Res. 2009;15(22):6830-40.
Connors JM. Prophylaxis against venous thromboembolism in ambulatory patients with cancer. N Engl J Med.2014;370(26):2515-9.20. Agnelli G, Bolis G, Capussotti L, et al. A clinical outcome-based prospective study on venous thromboembolism after cancer surgery: the @RISTOS project. Ann Surg. 2006;243(1):89-95.
Bergqvist D, Agnelli G, Cohen AT, et al. Duration of prophylaxis against venous thromboembolism with enoxaparin after surgery for cancer. N Engl J Med. 2002;346(13):975-80.
Siegal DM, Garcia D. Anticoagulants in cancer. J Thromb Haemost. 2012;10(11):2230-41.
Kakkar AK, Haas S, Wolf H, Encke A. Evaluation of perioperative fatal pulmonary embolism and death in cancer surgical patients: the MC-4 cancer substudy. Thromb Haemost. 2005;94(4):867-71.
Clagett GP, Reisch JS. Prevention of venous thromboembolism in general surgical patients. Results of meta-analysis. Ann Surg. 1988;208(2):227-40.
Geerts WH, Pineo GF, Heit JA, et al. Prevention of venous thromboembolism: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest. 2004;126(3 Suppl):338S-400S.
Committee on Practice Bulletins--Gynecology, American College of Obstetricians and Gynecologists. ACOG Practice Bulletin No. 84: Prevention of deep vein thrombosis and pulmonary embolism. Obstet Gynecol. 2007;110(2 Pt1):429-40.
Kahn SR, Lim W, Dunn AS, et al. Prevention of VTE in nonsurgical patients: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest. 2012;141(2Suppl):e195S-226S.
Rogers SO Jr, Kilaru RK, Hosokawa P, et al. Multivariable predictors of postoperative venous thromboembolic events after general and vascular surgery: results from the patient safety in surgery study. J Am Coll Surg. 2007;204(6):1211-21.
Bahl V, Hu HM, Henke PK, et al. A validation study of a retrospective venous thromboembolism risk scoring method. Ann Surg. 2010;251(2):344-50.
Shaw HA, Shaw JA. Thromboembolism Prophylaxis in Gynecologic Surgery. Disponível em: http://emedicine. medscape.com/article/2098556-overview#a1. Acessado em 2015 (11 dez).
Sajid MS, Desai M, Morris RW, Hamilton G. Knee length versus thigh length graduated compression stockings for prevention of deep vein thrombosis in postoperative surgical patients. Cochrane Database Syst Rev. 2012;5:CD007162.
Sachdeva A, Dalton M, Amaragiri SV, Lees T. Elastic compression stockings for prevention of deep vein thrombosis. Cochrane Database Syst Rev. 2010;7:CD001484.
Kahn SR, Lim W, Dunn AS, et al. Prevention of VTE in nonsurgical patients: Antithrombotic Therapy and Prevention of Thrombosis,
th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest. 2012;141(2 Suppl):e195S-226S.
Prandoni P, Lensing AW, Cogo A, et al. The long-term clinical course of acute deep thrombosis. Ann Intern Med. 1996;125(1):1-7.
Carrier M, Le Gal G, Wells PS, et al. Systematic review: theTrousseau syndrome revisited: should we screen extensively for cancer in patients with venous thromboembolism? Ann Intern Med. 2008;149(5):323-33.
Dentali F, Douketis JD, Gianni M, Lim W, Crowther MA. Meta-analysis: anticoagulant prophylaxis to prevent symptomatic venous thromboembolism in hospitalized medical patients. Ann Intern Med. 2007;146(4):278-88.
Zhao JM, He ML, Xiao ZM, et al. Different types of intermittent pneumatic compression devices for preventing venous thromboembolism in patients after total hip replacement. Cochrane Database Syst Rev. 2012;11:CD009543.
Clarke-Pearson DL, Synan IS, Dodge R, et al. A randomized trial of low-dose heparin and intermittent pneumatic calf compression for the prevention of deep venous thrombosis after gynecologic oncology surgery. Am J Obstet Gynecol. 1993;168(4):1146-53; discussion 1153-4.
Maxwell GL, Synan I, Dodge R, Carroll B, Clarke-Pearson DL. Pneumatic compression versus low molecular weight heparin in gynecologic oncology surgery: a randomized trial. Obstet Gynecol. 2001;98(6):989-95.
Ginzburg E, Cohn SM, Lopez J, et al. Randomized clinical trial of intermittent pneumatic compression and low molecular weight heparin in trauma. Br J Surg. 2003;90(11):1338-44.
Chapelle C, Rosencher N, Jacques Zufferey P, et al. Prevention of venous thromboembolic events with low-molecular-weight heparin in the non-major orthopaedic setting: meta-analysis of randomized controlled trials. Arthroscopy. 2014;30(8):987-96.
Clarke-Pearson DL, DeLong E, Synan IS, et al. A controlled trial of two low-dose heparin regimens for the prevention of postoperative deep vein thrombosis. Obstet Gynecol. 1990;75(4):684-9.
Eriksson BI, Bauer KA, Lassen MR, Turpie AG. Fondaparinux compared with enoxaparin for the prevention of venous thromboembolism after hip-fracture surgery. N Engl J Med. 2001;345(18):1298-304.
Samama CM, Lecoules N, Kierzek G, et al. Comparison of fondaparinux with low molecular weight heparin for venous thromboembolism prevention in patients requiring rigid or semi-rigid immobilization for isolated non-surgical below-knee injury. J Thromb Haemost. 2013;11(10):1833-43.
Agnelli G, Piovella F, Buoncristiani P, et al. Enoxaparin plus compression stockings compared with compression stockings alone in the prevention of venous thromboembolism after elective neurosurgery. N Engl J Med. 1998;339(2):80-5.
Rocha AT, Braga P, Ritt G, Lopes AA. Inadequacy oh thromboprophylaxis in hospitalized medical matients. Rev Assoc Med Bras. 2006;52(6):441-6.
Deheinzelin D, Braga AL, Martins LC, Martins MA, Hernandez A, Yoshida WD, et al. Incorrect use of thromboprophylaxis for venous thromboembolism in medical and surgical patients: results of multicentric, observational and cross-sectional study in Brazil. J Thromb Haemost. 2006;4(6):1266-70.
