Bariatric surgery in individuals with severe cognitive impairment
report of two cases
Keywords:
Prader-Willi syndrome, Down syndrome, Bariatric surgery, Obesity, Intellectual disabilityAbstract
CONTEXT: Bariatric surgery has become the gold-standard treatment for refractory morbid obesity. Obesity is frequently associated with certain syndromes that include coexisting cognitive deficits. However, the outcomes from bariatric surgery in this group of individuals remain incompletely determined.CASE REPORT: A 25-year-old male with Prader-Willi syndrome, whose intelligence quotient (IQ) was 54, was admitted with a body mass index (BMI) of 55 kg/m2, associated with glucose intolerance. He underwent the Scopinaro procedure for biliopancreatic diversion, with uneventful postoperative evolution, and presented a 55% loss of excess weight one year after the surgery, with resolution of glucose intolerance, and without any manifestation of protein-calorie malnutrition. A 28-year-old male with Down syndrome, whose IQ was 68, was admitted with BMI of 41.5 kg/m2, associated with hypertension. He underwent Roux-en-Y gastric bypass, with uneventful postoperative evolution. He presented a 90% loss of excess weight one year after the surgery, with resolution of the hypertension. CONCLUSION: Bariatric surgery among individuals with intellectual impairment is a controversial topic. There is a tendency among these individuals to present significant weight loss and comorbidity control, but less than what is observed in the general obese population. The severity of the intellectual impairment may be taken into consideration in the decision-making process regarding the most appropriate surgical technique. Bariatric surgery is feasible and safe among these individuals, but further research is necessary to deepen these observations.
Downloads
References
World Health Organization. Global status report on noncommunicable diseases 2014. Geneva: World Health Organization ; 2014.
Adams TD, Gress RE, Smith SC, et al. Long-term mortality after gastric bypass surgery. N Engl J Med. 2007;357(8):753-61.
Melville CA, Cooper SA, McGrother CW, Thorp CF, Collacott R. Obesity in adults with Down syndrome: a case-control study. J Intellect Disabil Res. 2005;49(Pt 2):125-33.
Rimmer JH, Braddock D, Fujiura G. Prevalence of obesity in adults with mental retardation: implications for health promotion and disease prevention. Ment Retard. 1993;31(2):105-10.
Ohyama Y, Utsugi T, Uchiyama T, et al. Prevalence of diabetes in adult patients with Down's syndrome living in a residential home. Diabetes Care. 2000;23(5):705-6.
Heinberg LJ, Schauer PR. Intellectual disability and bariatric surgery: a case study on optimization and outcome. Surg Obes Relat Dis. 2014;10(6):e105-8.
Daigle CR, Schauer PR, Heinberg LJ. Bariatric surgery in the cognitively impaired. Surg Obes Relat Dis. 2015;11(3):711-4.
Bauchowitz AU, Gonder-Frederick LA, Olbrisch ME, et al. Psychosocial evaluation of bariatric surgery candidates: a survey of present practices. Psychosom Med. 2005;67(5):825-32.
Alqahtani AR, Elahmedi MO, Al Qahtani AR, Lee J, Butler MG. Laparoscopic sleeve gastrectomy in children and adolescents with Prader-Willi syndrome: a matched-control study. Surg Obes Relat Dis. 2016;12(1):100-10.
Musella M, Milone M, Leongito M, et al. The mini-gastric bypass in the management of morbid obesity in Prader-Willi syndrome: a viable option? J Invest Surg. 2014;27(2):102-5.
Fong AK, Wong SK, Lam CC, Ng EK. Ghrelin level and weight loss after laparoscopic sleeve gastrectomy and gastric mini-bypass for Prader-Willi syndrome in Chinese. Obes Surg. 2012;22(11):1742-5.
Kobayashi J, Kodama M, Yamazaki K, et al. Gastric bypass in a Japanese man with Prader-Willi syndrome and morbid obesity. Obes Surg. 2003;13(5):803-5.
Braghetto Miranda I, Rodríguez NA, Debandi Lizárraga A, et al. Síndrome Prader Willi asociado a obesidad mórbida: tratamiento quirúrgico [Surgical treatment of morbid obesity associated to Prader-Willi syndrome: report of 1 case]. Rev Med Chil. 2003;131(4):427-31.
Miyata M, Dousei T, Harada T, et al. Metabolic changes following gastroplasty in Prader-Willi syndrome--a case report. Jpn J Surg. 1990;20(3):359-64.
Brossy JJ. Biliopancreatic bypass in the Prader-Willi syndrome. Br J Surg. 1989;76(3):313.
Anderson AE, Soper RT, Scott DH. Gastric bypass for morbid obesity in children and adolescents. J Pediatr Surg. 1980;15(6):876-81.
Laurent-Jaccard A, Hofstetter JR, Saegesser F, Chapuis Germain G. Long-term Results of treatment of Prader-Willi Syndrome by Scopinaro's Bilio-pancreatic Diversion. Study of Three cases and the Effect of Dextrofenfluramine on the Postoperative Evolution. Obes Surg. 1991;1(1):83-7.
Marinari GM, Camerini G, Novelli GB, et al. Outcome of biliopancreatic diversion in subjects with Prader-Willi Syndrome. Obes Surg. 2001;11(4):491-5.
Gibbons E, Casey AF, Brewster KZ. Bariatric surgery and intellectual disability: Furthering evidence-based practice. Disabil Health J. 2017;10(1):3-10.
Foerste T, Sabin M, Reid S, Reddihough D. Understanding the causes of obesity in children with trisomy 21: hyperphagia vs physical inactivity. J Intellect Disabil Res. 2016;60(9):856-64.
Michalik M, Frask A, Lech P, Zdrojewski M, Doboszynska A. The usefulness of biliopancreatic diversion/Scopinaro operation in treatment of patients with Prader-Willi syndrome. Wideochir Inne Tech Maloinwazyjne. 2015;10(2):324-7.
Bingham NC, Rose SR, Inge TH. Bariatric surgery in hypothalamic obesity. Front Endocrinol (Lausanne). 2012;3:23.
Mechanick JI, Youdim A, Jones DB, et al. Clinical practice guidelines for the perioperative nutritional, metabolic, and nonsurgical support of the bariatric surgery patient--2013 update: cosponsored by American Association of Clinical Endocrinologists, The Obesity Society, and American Society for Metabolic & Bariatric Surgery. Obesity (Silver Spring). 2013;21 Suppl 1:S1-27.
Galioto R, Gunstad J, Heinberg LJ, Spitznagel MB. Adherence and weight loss outcomes in bariatric surgery: does cognitive function play a role? Obes Surg. 2013;23(10):1703-10.
Rochette AD, Spitznagel MB, Strain G, et al. Mild cognitive impairment is prevalent in persons with severe obesity. Obesity (Silver Spring). 2016;24(7):1427-9.