Prevalence of prognostic factors for cancer of the uterine cervix after radical hysterectomy

Authors

  • Marília Buenos Aires Cabral Tavares Hospital São Marcos and Universidade Federal do Piauí
  • Rodrigo Beserra Sousa Hospital São Marcos and Universidade Federal do Piauí
  • Thiago Oliveira e Silva Hospital São Marcos and Universidade Federal do Piauí
  • Larissa Almeida Moreira Hospital São Marcos and Universidade Federal do Piauí
  • Loyana Teresa Teófilo Lima Silva Hospital São Marcos and Universidade Federal do Piauí
  • Carolina Buenos Aires Cabral Tavares Hospital São Marcos and Universidade Federal do Piauí
  • Sabas Carlos Vieira Hospital São Marcos and Universidade Federal do Piauí

Keywords:

Survival analysis, Cervix uteri, Uterine neoplasms, Hysterectomy, Gynecologic, surgical procedures

Abstract

CONTEXT AND OBJECTIVE: Cancer of the uterine cervix is still very common in Brazil. It is important to evaluate factors that influence its prognosis. The aim here was to analyze the prevalence of prognostic anatomoclinical factors among patients with carcinoma of the uterine cervix undergoing radical hysterectomy. DESIGN AND SETTING: Cross-sectional study on 301 patients with invasive carcinoma of the uterine cervix who underwent Level III Piver-Rutledge hysterectomy surgery at São Marcos Hospital. METHODS: The following variables were analyzed: age, histological type, degree of differentiation, invasion of lymphatic, vascular and perineural space, lymph node metastasis, distance to nearest margin, tumor invasion depth, vaginal cuff size, largest diameter of the tumor, presence of necrosis and surgical margin involvement. Descriptive statistics, multiple regression analysis, Kaplan-Meier survival curves and the log-rank test were performed. A significance level of 5% was used. RESULTS: The mean age was 48.27 years. The following were not important for the prognosis, in relation to survival analysis: degree of differentiation and tumor invasion depth; presence of lymphatic, blood and perineural invasions; distance to nearest margin; and vaginal cuff size. Tumor size (P < 0.036), presence of lymph node metastasis (P < 0.0004), necrosis (P < 0.05) and surgical margin involvement (P < 0.0015) presented impacts on survival. The overall survival with 98 months of follow-up was 88.35%. CONCLUSION: The most prevalent prognostic factors were the presence of lymph node metastasis, tumor size and surgical margin involvement.

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Author Biographies

Marília Buenos Aires Cabral Tavares, Hospital São Marcos and Universidade Federal do Piauí

Universidade Federal do Ceará, Hospital Universitário Walter Cantídio , Fortaleza, , Brazil.

Rodrigo Beserra Sousa, Hospital São Marcos and Universidade Federal do Piauí

Universidade Federal do Piauí, School of Medicine, Teresina, Brazil.

Thiago Oliveira e Silva, Hospital São Marcos and Universidade Federal do Piauí

Universidade Federal do Piauí, School of Medicine, Teresina, Brazil.

Larissa Almeida Moreira, Hospital São Marcos and Universidade Federal do Piauí

Universidade Federal do Piauí, Teresina, Brazil.

Loyana Teresa Teófilo Lima Silva, Hospital São Marcos and Universidade Federal do Piauí

Universidade Federal do Piauí, Teresina, Brazil.

Carolina Buenos Aires Cabral Tavares, Hospital São Marcos and Universidade Federal do Piauí

Universidade Federal do Ceará, Maternidade-Escola Assis Chateaubriand, Fortaleza, Brazil.

Sabas Carlos Vieira, Hospital São Marcos and Universidade Federal do Piauí

Universidade Federal do Piauí, Teresina, Brazil.

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Published

2009-05-05

How to Cite

1.
Tavares MBAC, Sousa RB, Silva TO e, Moreira LA, Silva LTTL, Tavares CBAC, Vieira SC. Prevalence of prognostic factors for cancer of the uterine cervix after radical hysterectomy. Sao Paulo Med J [Internet]. 2009 May 5 [cited 2025 Mar. 14];127(3):145-9. Available from: https://periodicosapm.emnuvens.com.br/spmj/article/view/1958

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Original Article