del 11(q23) as a prognostic factor of iron overload in refractory anemia with ringed sideroblasts

Authors

  • Maria de Lourdes Lopes Ferrari Chauffaille Universidade Federal de São Paulo
  • José Tadeu Stéfano Universidade Federal de São Paulo
  • Rosana Maria Valério Universidade Federal de São Paulo
  • Maura Romeo Universidade Federal de São Paulo
  • Maria Madalena Rodrigues Universidade Federal de São Paulo
  • José Kerbauy Universidade Federal de São Paulo

Keywords:

Myelodysplasia, Iron overload, Refractory anemia with ringed sideroblasts, Karyotype

Abstract

We present the case of a patient with MDS RARS subtype with loss of part of the long arm of chromosome 11 del 11(q23). This a cytogenetic abnormality that occurs in 7% to 20% of RARS cases not related to poor prognosis. It seems that this deletion is a marker of iron overload in MDS.

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Author Biographies

Maria de Lourdes Lopes Ferrari Chauffaille, Universidade Federal de São Paulo

Universidade Federal de São Paulo, Escola Paulista de Medicina, São Paulo, São Paulo, Brazil.

José Tadeu Stéfano, Universidade Federal de São Paulo

Universidade Federal de São Paulo, Escola Paulista de Medicina, São Paulo, São Paulo, Brazil.

Rosana Maria Valério, Universidade Federal de São Paulo

Universidade Federal de São Paulo, Escola Paulista de Medicina, São Paulo, São Paulo, Brazil.

Maura Romeo, Universidade Federal de São Paulo

Universidade Federal de São Paulo, Escola Paulista de Medicina, São Paulo, São Paulo, Brazil.

Maria Madalena Rodrigues, Universidade Federal de São Paulo

Universidade Federal de São Paulo, Escola Paulista de Medicina, São Paulo, São Paulo, Brazil

José Kerbauy, Universidade Federal de São Paulo

Universidade Federal de São Paulo, Escola Paulista de Medicina, São Paulo, São Paulo, Brazil

References

Bennet, JM; Catovsky, D; Daniel, MT; Flandrin, G; Galton, DAG; Gralnick, HR; Sultan, C: Proposals for the classification of myelodysplastic syndromes. British J Haematol 1982 51:189-199.

Heim, S: Cytogenetic findings in primary and secondary MDS. Leukemia Res 1992 16(1): 43-46.

Chauffaille, MLLF; Yamamoto, M; Odone, FV; Almeida, MT; Maluf Jr, P; Cristofani, LM; Kerbauy, J; Raimondi, SC: A t(9;11) translocation in childhood acute myeloid mixed leukemia . São Paulo Med Journ 1996 114(2):1127-30.

Smadja, N; Krulick, M; de Gramont, A; Brissaud, P; Debray, J : Acquired idiopathic sideroblastic anemia and terminal deletion of chromosome 11. Cancer Genet Cytogenet 1 985 16: 275-278.

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Published

1997-07-07

How to Cite

1.
Chauffaille M de LLF, Stéfano JT, Valério RM, Romeo M, Rodrigues MM, Kerbauy J. del 11(q23) as a prognostic factor of iron overload in refractory anemia with ringed sideroblasts. Sao Paulo Med J [Internet]. 1997 Jul. 7 [cited 2025 May 31];115(4):1513-5. Available from: https://periodicosapm.emnuvens.com.br/spmj/article/view/2136

Issue

Vol. 115 No. 4 (1997)

Section

Case Report

License

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.