Monoamine responses to acute and chronic aerobic exercise in normotensive and hypertensive subjects
Palavras-chave:
Monoamines, Aerobic exercise, Physical training, Hypertension, HumansResumo
OBJETIVOS: O propósito do presente. estudo foi comparar os níveis sanguíneos de monoaminas de homens sedentários normotensos e hipertensos na situação de repouso, com indivíduos submetidos a uma sessão de exercício fisico e após um programa de 12 semanas de treinamento aeróbio. LOCAL: Os dados obtidos para este estudo foram coletados de uma clinica para prevenção e reabilitação de doença cardiovascular (FITCOR) e analisados no Laboratório de Neurologia Experimental da Escola Paulista de Medicina (UNIFESP). PARTICIPANTES: Dois grupos de homens sedentários, normotensos (N=16) e hipertensos (N=19), foram submetidos a uma sessão de exercício físico para analisar o efeito agudo do exercïcio sobre os níveis de monoaminas circulantes. Alguns indivíduos de cada grupo (normotensos (N=11) e hipertensos (N=8)) foram incluí-dos para o estudo do efeito crônico do exercício. MENSURAÇÃO: Os níveis sanguíneos de monoaminas foram determinados por cromatografia líquida de alta eficiência com detecção eletroquímica. RESULTADOS: Foi observado uma significativa redução da pressão arterial diastólica em repouso no grupo hipertenso após o programa de treinamento físico. Somente a concentraçâo plasmática de noradrenalina apresentou um aumentou significativo após uma sessão de exercício físico em todos os grupos. CONCLUSÃO: Estes dados mostram o efeito benéfico do exercício físico em reduzir a pressão sanguínea em pacientes hipertensos, o qual não parece estar relacionado com as alterações de monoaminas circulantes.
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