Paragangliomas of the head and neck

clinical, morphological and immunohistochemical aspects

Authors

  • Pedro de Alcântara de Andrade Filho Head and Neck Service of Heliópolis Hospital (Hosphel), and Pathology Service of Oswaldo Cruz Hospital
  • Abrão Rapoport Head and Neck Service of Heliópolis Hospital (Hosphel), and Pathology Service of Oswaldo Cruz Hospital
  • Venâncio Avancini Ferreira Alves Head and Neck Service of Heliópolis Hospital (Hosphel), and Pathology Service of Oswaldo Cruz Hospital
  • Odilon Victor Porto Denardin Head and Neck Service of Heliópolis Hospital (Hosphel), and Pathology Service of Oswaldo Cruz Hospital
  • Josias de Andrade Sobrinho Head and Neck Service of Heliópolis Hospital (Hosphel), and Pathology Service of Oswaldo Cruz Hospital
  • Marcos Brasilino de Carvalho Head and Neck Service of Heliópolis Hospital (Hosphel), and Pathology Service of Oswaldo Cruz Hospital

Keywords:

Paragangliomas, Markers, AgKi67, Chromogranin, S100 protein

Abstract

CONTEXT: Protein marker positivity can assist in the definition of the therapeutic approach towards head and neck paragangliomas. The establishment of the therapeutic approach should incorporate the results of such an investigation. OBJECTIVE: To establish criteria for benignancy and malignancy of vagal and jugular-tympanic paragangliomas, via the study of the relationships of sex, age, tumor size, duration of complaints, site, family history, presence of metastases, treatment, histological architecture and cell type with the immunohistochemical reactions to S100 protein, chromogranin and AgKi67. DESIGN: A retrospective study of histological and clinical records. SETTING: The Heliópolis and Oswaldo Cruz tertiary general hospitals, São Paulo. SAMPLE: 8 cases of head and neck paragangliomas. MAIN MEASUREMENTS: Determination of degree of positivity to paragangliomas via immunohistochemical reactions. RESULTS: 1). The protein markers for the principal cells (AgKi67 and chromogranin) were sensitive in 100% of the tumors when used together. 2). S100 protein was well identified in the cytoplasm and nucleus of sustentacular cells and underwent reduction in the neoplasias. CONCLUSIONS: Chromogranin was proven to be a generic marker for neuroendocrine tumors; S100 protein was positive in all 8 cases and the AgKi67 had low positivity in all cases.

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Author Biographies

Pedro de Alcântara de Andrade Filho, Head and Neck Service of Heliópolis Hospital (Hosphel), and Pathology Service of Oswaldo Cruz Hospital

MD. Head and Neck Surgery, Hospital Heliópolis, São Paulo, Brazil.

Abrão Rapoport, Head and Neck Service of Heliópolis Hospital (Hosphel), and Pathology Service of Oswaldo Cruz Hospital

MD, PhD. Head and Neck Surgery, Hospital Heliópolis (Hosphel), São Paulo, Brazil.

Venâncio Avancini Ferreira Alves, Head and Neck Service of Heliópolis Hospital (Hosphel), and Pathology Service of Oswaldo Cruz Hospital

MD, PhD. Pathology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.

Odilon Victor Porto Denardin, Head and Neck Service of Heliópolis Hospital (Hosphel), and Pathology Service of Oswaldo Cruz Hospital

PhD. Head and Neck Surgery, Hospital Heliópolis, São Paulo, Brazil.

Josias de Andrade Sobrinho, Head and Neck Service of Heliópolis Hospital (Hosphel), and Pathology Service of Oswaldo Cruz Hospital

PhD. Head and Neck Surgery, Hospital Heliópolis, São Paulo, Brazil.

Marcos Brasilino de Carvalho, Head and Neck Service of Heliópolis Hospital (Hosphel), and Pathology Service of Oswaldo Cruz Hospital

PhD. Head and Neck Surgery, Hospital Heliópolis, São Paulo, Brazil.

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Published

2001-05-05

How to Cite

1.
Andrade Filho P de A de, Rapoport A, Alves VAF, Denardin OVP, Sobrinho J de A, Carvalho MB de. Paragangliomas of the head and neck: clinical, morphological and immunohistochemical aspects. Sao Paulo Med J [Internet]. 2001 May 5 [cited 2025 Mar. 14];119(3):114-8. Available from: https://periodicosapm.emnuvens.com.br/spmj/article/view/2759

Issue

Vol. 119 No. 3 (2001)

Section

Original Article

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