Paragangliomas of the head and neck

clinical, morphological and immunohistochemical aspects

Autores

  • Pedro de Alcântara de Andrade Filho Head and Neck Service of Heliópolis Hospital (Hosphel), and Pathology Service of Oswaldo Cruz Hospital
  • Abrão Rapoport Head and Neck Service of Heliópolis Hospital (Hosphel), and Pathology Service of Oswaldo Cruz Hospital
  • Venâncio Avancini Ferreira Alves Head and Neck Service of Heliópolis Hospital (Hosphel), and Pathology Service of Oswaldo Cruz Hospital
  • Odilon Victor Porto Denardin Head and Neck Service of Heliópolis Hospital (Hosphel), and Pathology Service of Oswaldo Cruz Hospital
  • Josias de Andrade Sobrinho Head and Neck Service of Heliópolis Hospital (Hosphel), and Pathology Service of Oswaldo Cruz Hospital
  • Marcos Brasilino de Carvalho Head and Neck Service of Heliópolis Hospital (Hosphel), and Pathology Service of Oswaldo Cruz Hospital

Palavras-chave:

Paragangliomas, Marcadores, AgKi67, Cromogranina e proteína S100

Resumo

CONTEXTO:. A marcação positiva pode auxiliar na escolha da terapêutica dos paragangliomas de cabeça e pescoço. A definição do tratamento deve ser realizada incorporando o resultado desses testes. OBJETIVO: Por meio do estudo da relação do sexo, idade, tamanho de lesão, tempo de queixa, localização, história familiar, metástase, tratamento, arquitetura, tipo celular com as reações imunohistoquímicas para proteína S100, cromogranina e AgKi67, estabelecimento de critérios de benignidade e malignidade dos paragangliomas vagais e júgulo-timpânicos. TIPO DE ESTUDO: Estudo retrospectivo de arquivos histológicos e clínicos. LOCAL: Hospital Heliópolis e Oswaldo Cruz, São Paulo. PARTICIPANTES: Oito casos de paragangliomas de cabeça e pescoço. VARIÁVEIS ESTUDADAS: Grau de positividade para paragangliomas com reação imunohistoquímica. RESULTADOS: Os marcadores protéicos para as células principais (AgKi67 e cromogranina) foram sensíveis em 100% das neoplasias quando usados conjuntamente; A proteína S100 foi bem identificada no citoplasma e núcleo das células sustentaculares e sofre diminuição nas neoplasias. CONCLUSÕES: a cromogranina comprovou ser um marcador genérico para os tumores neuro-endócrinas, a proteína S100 foi positiva nos oito casos e o Ki67 foi baixo em todos os casos.

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Biografia do Autor

Pedro de Alcântara de Andrade Filho, Head and Neck Service of Heliópolis Hospital (Hosphel), and Pathology Service of Oswaldo Cruz Hospital

MD. Head and Neck Surgery, Hospital Heliópolis, São Paulo, Brazil.

Abrão Rapoport, Head and Neck Service of Heliópolis Hospital (Hosphel), and Pathology Service of Oswaldo Cruz Hospital

MD, PhD. Head and Neck Surgery, Hospital Heliópolis (Hosphel), São Paulo, Brazil.

Venâncio Avancini Ferreira Alves, Head and Neck Service of Heliópolis Hospital (Hosphel), and Pathology Service of Oswaldo Cruz Hospital

MD, PhD. Pathology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.

Odilon Victor Porto Denardin, Head and Neck Service of Heliópolis Hospital (Hosphel), and Pathology Service of Oswaldo Cruz Hospital

PhD. Head and Neck Surgery, Hospital Heliópolis, São Paulo, Brazil.

Josias de Andrade Sobrinho, Head and Neck Service of Heliópolis Hospital (Hosphel), and Pathology Service of Oswaldo Cruz Hospital

PhD. Head and Neck Surgery, Hospital Heliópolis, São Paulo, Brazil.

Marcos Brasilino de Carvalho, Head and Neck Service of Heliópolis Hospital (Hosphel), and Pathology Service of Oswaldo Cruz Hospital

PhD. Head and Neck Surgery, Hospital Heliópolis, São Paulo, Brazil.

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Publicado

2001-05-05

Como Citar

1.
Andrade Filho P de A de, Rapoport A, Alves VAF, Denardin OVP, Sobrinho J de A, Carvalho MB de. Paragangliomas of the head and neck: clinical, morphological and immunohistochemical aspects. Sao Paulo Med J [Internet]. 5º de maio de 2001 [citado 14º de março de 2025];119(3):114-8. Disponível em: https://periodicosapm.emnuvens.com.br/spmj/article/view/2759

Edição

v. 119 n. 3 (2001)

Seção

Artigo Original

Licença

Creative Commons License
Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.