Congenital papillomas and papillomatoses associated with the Human Papilloma Virus (HPV)
report on 5 cases
Keywords:
Congenital Papilloma, HPV, PapillomatosisAbstract
The authors present a study of five cases of vulvar congenital papillomas and papillomatoses in stillborns and neonates dead upon birth. The studied material was collected from five necropsies. The histopathological evaluation showed hyperkeratosis, acanthosis, papillomatosis, perinuclear haloes, and nuclear abnormalities. In three of the cases, the electron microscopy identified nuclear and cytoplasmatic viral particles ranging from 40 to 60 nm in size, compatible with HPV. The immunohistochemical study of those lesions showed nuclear and cytoplasmatic positivity. The authors concluded that the presence of viral particles suggestive of HPV added to the immunopositivity indicated the possibility of viral infection.
Downloads
References
ORTH, G. et alii. The human papillomaviruses. Bull. Cancer, 65: 151-164, 1978.
OSTROW, R.S. & FARAS, A.J. The molecular biology of Human papillomaviroses and the pathogenesis of genital papillomas and neoplasma. Cancer and Metastasis Review, 6: 383-395, 1987.
SYRJANEN, K.J. Epidemiology of Human papillomavirus (HPV) infection and their associations with genital squamous cell cancer. APMIS, 97: 957-970, 1989.
DIAS, E.P. Papillomavirus humano: aspectos biológicos, clínicos e morfológicos. JMB, 64 (6): 206-17, 1993.
DE JONG, A.R., WEISS, J.C. & BRENT, R.L. Condyloma acuminata in children. Am. J. Dis. Child., 136 (8): 704-706, August, 1982.
TANG, C-k; SHERMETA, D & WOOD, C Congenital condyloma acuminata. Am. J. Obst. & Ginecol., 15:912-913, 1978.
STUMPF, P.G. Increasing occurrence of condylomata acuminata in premenarchal children. Obst. & Ginecol., 56 (2): 262-264, 1980.
JONES, J.G. Sexual abuse of children. Current concepts. Am, J. Dis. Child., 136 (2): 142-146, 1982.
DE JONG, A.R. Sexually transmitted diseases in children. Am. Fam. Physician., 30 (1): 185-193, 1984.
STRINGEL, G., MERCER, S. & CORSINI, L Condyloma acuminata in children. J. Pediatri. Surg., 20 (5) : 499 - 501, 1985.
ROCK, B. et alii. Genital tract papillomavirus infection in children. Arch. Dermatol. 122 (10) :1129-1132, Oct, 1986.
BENDER, M.E. New concepts of condyloma acuminata in children. Arch. Dermatol., 122 (10): 1121-1124, Oct, 1986.
VALLEJOS, H. et alii. Characterization of Human Papilloma Virus types in condylomata acuminata in children by in situ hybridization. Lab. Invest., 56 (6): 611-615, 1987.
STEINBERG, B.M. Papillomavirus. Effects upon mother and child. Ann. N. Y. Acad. Sci., 549 (12): 118-128, 1988.
SINGH, K.G., BAJAJ, A.K. & SHAPMA, R. Perianal condyloma acuminatum in an infant. Int. J. Dermatol., 27 (3): 181-182, 1988.
GIBSON, P.E., GARDNER, S.D. & BEST, S.J. Human papillomavirus types in anogenital warts of children. J. Med. Virol., 30 (2): 142-145, Feb, 1990.
BOYD, AS. Condylomata acuminata in the pediatric population. Am. J. Dis. Child., 144 (7): 817-824, 1990.
NUOVO, G.J. et alii. Human papillomavirus segregation patterns in genital and nongenital warts in prepuberal children and adults. Am. J. Clin. Pathol., 95: 467-474, 1991.
CRAIGHILL, M.C. Human Papillomavirus Infection in Children and Adolescents. Sem. Pediatr. Infect. Dis., 4 (2): 85-93, 1993.
CHACKO, M.R. & TABER, L.H. Epidemiology of Sexually transmitted Diseases in Children and Adolescents in the United States. Sem. Pediatr. infect. Dis., 4 (2): 71-76, 1993.
HORDING, U. et alii. Prevalence of Human papillomavirus types 11, 16 and 18 in cervical swabs. A study of 1362 pregnant women. Eur. J. Obst. et Gynecol. Reprod. Biol., 35 (2-3): 192-8, 1990.
BEURET, T., SADOUL, G., FARL, A., IONESCO, M. & DE BRUX, J. Estude epidemiologique comparative entre 120 patientes atteintes de lesion condylomateuse et 120 patientes temoins. J. Gynecol. Obstet. Biol. Reprod. (Paris), 16 (5): 555-564, 1987.
GARRY, R. & JONES, R. Relationship between cervical condylomata, pregnancy and subclinical papillomavirus infection. J. Reprod. Med., 30 (5): 395-399, 1985.
RAYMOND, F.R. & THOMAS, R.J. Condyloma acuminatum in pregnancy. J. Am. Osteopath. Assoc., 82 (10): 774-778,1983.
HALLDEN, C. & MAJMUDAR, B. The relationship between juvenil laryngeal papillomatosis and maternal condylomata acuminata. J. Reprod. Med., 31 (9): 804-807, 1986.
KJER, J.J., ELDON, K. & DREISLER, A. Maternal condylomata and juvenil laryngeal papillomas in their children. Zentralbl. Gynakol., 110 (2): 107-110,1988.
FLETCHER, J.L.Jr. Perinatal transmission of Human papillomavirus. Am. Fam. Physician., 43 (1): 143-8, 1991.
CALKINS, J. W., MASTERSON, B.J., MAGRINA, J.F. & CAPEN, C.V. Management of condylomata acuminata with the carbon dioxide laser. Obstet. Gynecol., 59 (1): 105-108, 1982.
BERGMAN, A., MATSUNAGA, J. & BHATIA, N.N. Cervical cryotherapy for condylomata acuminata during pregnancy. Obstet. Gynecol., 69 (1): 47-50, 1987.
MATSUNAGA, J., BERGMAN, A. & BHATIA, N.N Genital condylomata acuminata in pregnancy: effectiveness, safety and pregnancy outcome following cryotherapy. Br. J. Obstet. Gynecol., 94 (2): 168-172, 1987.
AUDRA, P. [The management of pregnant women presenting with genital HPV infections]. Rev. Fr. Gynecol. Obstet., 85 (10): 561-3, 1990.
ROGO, K.O. & NYANSERA, P.N. Congenital condylomata acuminata with meconium staining of amniotic fluid and fetal hydrocephalus: case report. East. Afr. Med. J., 66 (6): 411-413, Jun, 1989.
PATSNER, B., BAKER, D.A. & JAMES, W.O.Jr. Human papillomavirus genital tract infections during pregnancy. Clin. Obstet. and Gynecol., 33 (2): 258-267, 1990.
ROMAN, A. & FIFE K. Human papillomavirus DNA associated with foreskins of normal newborns. L. Infect. Dis., 153: 855, 1986.
SEDLACEK, T.V., LINDHEIM, S. Eder, C. et alii. Mechanism for human papillomavirus transmission at birth. Am. J. Obstet. Gynecol., 161: 55, 1989.
TSENG, CJ. et alii. - Possible transplacental transmission of human papillomaviruses. Am. J. Obstet. Gynecol., 166: 35-40, 1992.
BERGERON, C., FERENCZY, A., RICHART, R.M. & GURALNICK, M. Micropapillomatosis Labialis appears unrelated to Human papillomavirus. Obstet. Gynecol., 76 (2): 281-286, 1990.
COSTA, S. et alii. Is vestibular papillomatosis associated with Human papillomavirus? J. Med. Virol., 35: 7-13, 1991.
McKAY, M. Vulvite and vulvovaginitis: cutaneous considerations. Am. J. Obstet. Gynecol., 165 (4): 1176-1182,1991.
MARINOFF, S. C. & TURNER, M.L.C. Vulvar vestibulitis syndrome: an overview. Am. J. Obstet. Gynecol., 165 (4): 1228-1233, 1991.
WILKINSON, E.J. et alii. Vulvar vestibulitis is rarely associated with human papillomavirus infection types 6,11,16 or 18. Int. J. Gynecol. Pathol., 12 (4): 344-9, 1993.
ORIEL, J.D. Natural history of genital warts. Brit. J. Vener. Dis., 47: 1-13, 1971.
BAROUR, S., LINDELVF, B. & EKLUND, G. Condylomata acuminata and risk of cancer: an epidemiological study. BMJ, 303 (10): 341-344, 1991.
AYRE, J.R. The vaginal smear. "Precancer" cell studies using a modified technique. Am. J. Obstet. Gynecol., 58: 1205-1219, 1949.
REAGAN, J.W., HICKS, D.J. & SCOTY, R.B. Atypical hyperplasia of uterine cervix. Cancer, 8: 42-53, 1955.
KOSS, L.G. & DURFEE, G.R> Unusual patterns of squamous epithelium of the uterine cervix: cytologic and pathologic study of koilocytotic atypia. Ann. NY. Acad. Sci., 63: 1245-1261, 1956.
ORIEL, J.D. & ALMEIDA, J.D. Demonstration of virus particles in human genital warts. Brit. J. Vener. Dis., 46: 37-42, 1970.
GONZALEZ-ANGULO, A., CHAVEZ, I.R. & CASTANEDA, M. A reliable method for electron microscopic examination of specific areas from paraffin-embedded tissue mounted on glass slides. Am. Soc. Clin. Pathol., 70 (4): 697-699, 1978.
KADISH, AS., BURK, R.D., KRESS, Y., CALDER S. & ROMNEY, S. Human Papillomaviruses of different types in precancerous lesions of the uterine cervix: Histologic, Immunocytochemical and ultrastuctural studies. Hum. Pathol., 17: 384-392, 1986.
OASHI, M. & OGIYAMA Y. Electron microscopic examination of cutaneous lesions by the quick rembedding method from paraffin-embedded blocks. J. Cutan. Pathol. 21: 239-246, 1994.
WOODRUFF, J.D. et alii. Immunologic identification of papillomavirus antigen in condyloma tissues from the female genital tract. Obstet. Gynecol., 56 (6): 727-732, 1980.
GOES JUNIOR, J.S. et alii: Presença de antígenos de papilomavírus em lesões pré-malignas da cérvice uterina no Brasil. Um estudo imuno-histoquímico de 90 casos. Rev. Bras. Ginec. Obstetr., maio/ junho: 128-133,1983.
PADAYACHEE, A. & Van WYK, W. Human Papillomavirus (HPV) in oral Squamous Cell papillomas. J. Oral. Pathol., 16: 353-355, 1987.
ZHOU, J. et alii. Identification of nuclear localization signal of human papillomavirus type 16 L1 protein. Virology, 185: 625-632, 1991.
SADOUL, G. & BEURET, T. Analyse d'une serie continue de 421 condylomes genitaux. Evolution, conduite et resultats therapeutiques. J. Gynecol. Obstet. Biol. Reprod., 14 (8): 1049-1058, 1985.
GLEW, S. & STERN, P.L. HLA antigens and cervical carcinoma. Nature, 356: 22, 1992.
BARCELLOS, J.M.P. et alii. Colo uterino: estudo na infante, recém-nascida e feto. Alguns aspectos cito e histopatológicos. Rev. Bras. de Cancerologia, 25 (3): 77-95, 1975.
MANDAL, D. et alii. Prevalence of occult human papillomavirus infection, determined by cytology and DNA hybridization, in heterosexual men attending a genitourinary medicine clinic. Int. J. STD AIDS, 2 (5): 351-5, 1991.
ROBERTSON, D.I. et alii. Cérvico-vaginal screening in an STD clinic. Can. J. Public. Health, 82 (4): 264-6, 1991.
MINCHEVA, A. et alii. Detection of human papillomavirus DNA in gynecological swabs by filter in situ hybridization. Acta. Virol. (Praha), 35 (3): 209-17, 1991.
NUOVO, G.J. et alii. Human papillomavirus segregation patterns in genital and nongenital warts in prepubertal children and adults. Am. J. Clin. Pathol., 95: 467-474, 1991.
REID, R. et alii. Sexually transmitted papillomaviral infections. Am. J. Obstet. Gynecol., 156 (1): 212-222, 1987.
WILSON, R.W., CHENGGIS, M.L. & UNDER, E.R. Longitudinal study of human papillomavirus infection of the female urogenital tract by in situ hybridization. Arch. Pathol. Lab. Med., 114: 155-159, 1990.
