Concomitant detection of hematological neoplasm and carcinoma
report on seven cases
Keywords:
Neoplasms, multiple primary, Lymphoma, non-Hodgkin’s, Carcinoma, Immunohistochemistry, PathologyAbstract
CONTEXT: The presence of multiple neoplasms in one patient is an uncommon event. Its occurrence ranges from 1.2% to 4.5% of cancer patients in autopsy and clinical studies. In the present article, cases of synchronous diagnoses of carcinoma and lymphoid neoplasms are reported. The intention of this report was to alert clinicians and pathologists to the possibility of the existence of concomitant neoplasms, in order to prevent inaccurate or delayed diagnosis and staging. CASES: Seven patients (four female and three male) with a median age of 61.4 years were diagnosed as having concomitant epithelial and hematological neoplasms. DISCUSSION AND CONCLUSION: Lymph nodes should be carefully examined when searching for metastases, because of the possibility of a second hematological malignancy. Whenever uncommon suspicious morphological features are seen in such neoplasms, an immunohistochemical analysis is essential.
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References
Carson HJ. Unexpected synchronous non-Hodgkin’s lymphoma encountered during the treatment of a previously-diagnosed carcinoma: report of three cases. Leuk Lymphoma. 1996;23(5- 6):625-9.
Pandey U, Naraynan M, Karnik U, Sinha B. Carcinoma metas- tasis to unexpected synchronous lymphoproliferative disorder: report of three cases and review of literature. J Clin Pathol. 2003;56(12):970-1.
Männel DN, Orosz P, Hafner M, Falk W. Mechanisms involved in metastasis enhanced by inflammatory mediators. Circ Shock. 1994;44(1):9-13.
Nakamura S, Aoyagi K, Iwanaga S, Yao T, Tsuneyoshi M, Fujishima M. Synchronous and metachronous primary gastric lymphoma and adenocarcinoma: a clinicopathological study of 12 patients. Cancer. 1997;79(6):1077-85.
Tamura K, Utsunomiya J, Iwama T, et al. Mechanism of carcinogenesis in familial tumors. Int J Clin Oncol. 2004;9(4): 232-45.
