Myelodysplastic syndromes (MDS)

prognostic factors and scoring systems

Authors

  • Elizabeth Xisto Souto Universidade Estadual Paulista; Universidade Federal de São Paulo.
  • Maria de Lourdes Lopes Ferrari Chauffaile Universidade Estadual Paulista; Universidade Federal de São Paulo.
  • José Eduardo Cajado Moncau Universidade Estadual Paulista; Universidade Federal de São Paulo.
  • Lígia Niero-Melo Universidade Estadual Paulista; Universidade Federal de São Paulo.
  • Gisele Wally Braga Universidade Estadual Paulista; Universidade Federal de São Paulo.
  • Maria Regina Regis Silva Universidade Estadual Paulista; Universidade Federal de São Paulo.
  • José Kerbauy Universidade Estadual Paulista; Universidade Federal de São Paulo.

Keywords:

Myelodysplastic syndromes, Prognosis, Survival

Abstract

OBJECTIVE: To evaluate the score systems of Cassano and Sanz and suggest a new one. DESIGN: Case series. LOCATION: Teaching hospitals: EPM UNIFESP and Faculdade de Medicina de Botucatu. PARTICIPANTS: 59 patients diagnosed from 1979 to 1992. INTERVENTION: Evaluation of clinical-laboratorial data. MEASUREMENT: Statistical comparison, uni and multivariate analysis and actuarial survival curves. RESULTS: Cassano's system divided the patients into high and low risk (p=0.0966) while, Sanz's gave high, intermediate and low risk (p=0.0108). The univariate analysis showed hemoglobin, WBC count, E/M ratio, liver size and blast percentage in BM as statistically significant. The multivariate analysis showed blast percentage in BM (p=0.004) and Hb (p=0.050) as significant. Our system, considering the multivariate analysis data, divided the patients into high, intermediate and low risk (p=0.0038). CONCLUSIONS: Sanz's system was more functional than Cassano's, while ours showed predictive survival value and ease of use in clinical practice.

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Author Biographies

Elizabeth Xisto Souto, Universidade Estadual Paulista; Universidade Federal de São Paulo.

Universidade Estadual Paulista, São Paulo, Brazil. Universidade Federal de São Paulo, Escola Paulista de Medicina , São Paulo, São Paulo, Brazil.

Maria de Lourdes Lopes Ferrari Chauffaile, Universidade Estadual Paulista; Universidade Federal de São Paulo.

Universidade Estadual Paulista, São Paulo, Brazil. Universidade Federal de São Paulo, Escola Paulista de Medicina , São Paulo, São Paulo, Brazil.

José Eduardo Cajado Moncau, Universidade Estadual Paulista; Universidade Federal de São Paulo.

Universidade Estadual Paulista, São Paulo, Brazil. Universidade Federal de São Paulo, Escola Paulista de Medicina , São Paulo, São Paulo, Brazil.

Lígia Niero-Melo, Universidade Estadual Paulista; Universidade Federal de São Paulo.

Universidade Estadual Paulista, São Paulo, Brazil. Universidade Federal de São Paulo, Escola Paulista de Medicina , São Paulo, São Paulo, Brazil.

Gisele Wally Braga, Universidade Estadual Paulista; Universidade Federal de São Paulo.

Universidade Estadual Paulista, São Paulo, Brazil. Universidade Federal de São Paulo, Escola Paulista de Medicina, São Paulo, São Paulo, Brazil.

Maria Regina Regis Silva, Universidade Estadual Paulista; Universidade Federal de São Paulo.

Universidade Estadual Paulista, São Paulo, Brazil. Universidade Federal de São Paulo, Escola Paulista de Medicina, São Paulo, São Paulo, Brazil.

José Kerbauy, Universidade Estadual Paulista; Universidade Federal de São Paulo.

Universidade Estadual Paulista, São Paulo, Brazil. Universidade Federal de São Paulo, Escola Paulista de Medicina, São Paulo, São Paulo, Brazil.

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Published

1997-09-09

How to Cite

1.
Souto EX, Chauffaile M de LLF, Moncau JEC, Niero-Melo L, Braga GW, Silva MRR, Kerbauy J. Myelodysplastic syndromes (MDS): prognostic factors and scoring systems. Sao Paulo Med J [Internet]. 1997 Sep. 9 [cited 2025 Oct. 16];115(5):1537-41. Available from: https://periodicosapm.emnuvens.com.br/spmj/article/view/2148

Issue

Vol. 115 No. 5 (1997)

Section

Original Article

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