Granulocytic sarcoma presented as a reactivation of chronic myeloid leukemia after allogenic marrow transplantation

Authors

  • José Salvador Rodigues de Oliveira Universidade Federal de São Paulo
  • Maria de Lourdes Lopes Ferrari Chauffaille Universidade Federal de São Paulo
  • Gisele Wally Braga Colleoni Universidade Federal de São Paulo
  • Vânia Maris Morelli Universidade Federal de São Paulo
  • Omar Magid Hauache Universidade Federal de São Paulo
  • Vânia Nosé Alberti Universidade Federal de São Paulo
  • José Kerbauy Universidade Federal de São Paulo

Keywords:

Granulocytic sarcoma, Bone marrow transplantation, Chronic myeloid leukemia, Hypercalcemia

Abstract

The authors report the case of a chronic myeloid leukemia (CML) patient submitted to allogenic bone marrow transplantation, who had probably never entered complete remission. The disease was reactivated as a granulocytic sarcoma, next to a platinum plate installed to correct a tibia fracture 11 years earlier. Its final event was a myeloid Ph1+ blastic crisis that was unsuccessfully treated with high doses of sc interferon and citarabine.

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Author Biographies

José Salvador Rodigues de Oliveira, Universidade Federal de São Paulo

Universidade Federal de São Paulo, Department of Pathology, Discipline of Hematology, Hemotherapy and Endocrinology, Escola Paulista de Medicina, São Paulo, Brazil.

Maria de Lourdes Lopes Ferrari Chauffaille, Universidade Federal de São Paulo

Universidade Federal de São Paulo, Department of Pathology, Discipline of Hematology, Hemotherapy and Endocrinology, Escola Paulista de Medicina, São Paulo, Brazil.

Gisele Wally Braga Colleoni, Universidade Federal de São Paulo

Universidade Federal de São Paulo, Department of Pathology, Discipline of Hematology, Hemotherapy and Endocrinology, Escola Paulista de Medicina, São Paulo, Brazil.

Vânia Maris Morelli, Universidade Federal de São Paulo

Universidade Federal de São Paulo, Department of Pathology, Discipline of Hematology, Hemotherapy and Endocrinology, Escola Paulista de Medicina, São Paulo, Brazil.

Omar Magid Hauache, Universidade Federal de São Paulo

Universidade Federal de São Paulo, Department of Pathology, Discipline of Hematology, Hemotherapy and Endocrinology, Escola Paulista de Medicina, São Paulo, Brazil.

Vânia Nosé Alberti, Universidade Federal de São Paulo

Universidade Federal de São Paulo, Department of Pathology, Discipline of Hematology, Hemotherapy and Endocrinology, Escola Paulista de Medicina, São Paulo, Brazil.

José Kerbauy, Universidade Federal de São Paulo

Universidade Federal de São Paulo, Department of Pathology, Discipline of Hematology, Hemotherapy and Endocrinology, Escola Paulista de Medicina, São Paulo, Brazil.

References

Harris DWS, Osterele LS, Rustin MHA. Cutaneous granulocytic sarcoma (chloroma) presenting as the first sign of relapse following autologous bone marrow transplantation for acute myeloid leukemia. Br J Haematol 1992; 127:182-184.

Champlin RE, Golde DW. Chronic myelogenous leukemia: recent advances. Blood 1985; 65:1039-1047.

Clift RA, Buckner CD, Thomas ED, et al. Marrow transplantation for chronic myeloid leukemia: a randomized study comparing cyclophosphamide and total body irradiation with bussulfan and cyclophosphamide. Blood 1994; 84:2036-43.

Sullivan KM, Kopercky KJ, Jocom J, et al. Immunomodulatory and antimicrobial efficacy of intravenous immunoglobulin in bone marrow transplantation. N Engl J Med 1990; 323:705-712.

Sullivan KM, Storek J, Kopecky KJ, et al. A controlled trial of long-term administration of IV immunoglobulin to prevent late infection and chronic GVHD after marrow transplantation: clinical outcome and effect of subsequent immune recovery. Biology of Blood and Marrow Transplantation. 1996; 2:44-53.

Kubota K, Yanagisawa T, Kurubayashi H, et al. Hypercalcemia associated with osteolytic lesions in extramedullary blastic crisis of chronic myelogenous leukemia: report of a case. Blut 1989; 59:458-459.

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Published

1998-03-03

How to Cite

1.
Oliveira JSR de, Chauffaille M de LLF, Colleoni GWB, Morelli VM, Hauache OM, Alberti VN, Kerbauy J. Granulocytic sarcoma presented as a reactivation of chronic myeloid leukemia after allogenic marrow transplantation. Sao Paulo Med J [Internet]. 1998 Mar. 3 [cited 2025 Jun. 7];116(2):1689-91. Available from: https://periodicosapm.emnuvens.com.br/spmj/article/view/2266

Issue

Section

Case Report