Use of autologous fibrin glue in dermatologic surgery
application of skin graft and second intention healing
Keywords:
Fibrin glue, Wound healing, Skin cancer, Dermatologic surgeryAbstract
OBJECTIVE: To evaluate the efficiency of biological sealant, an autologous fibrin glue, in dermatological surgery. DESIGN: Randomized clinical trial. SETTING: The Dermatology Service of Hospital das Clínicas, Universidade de Campinas (UNICAMP), referral center. PATIENTS: 14 patients with malign epithelial cutaneoos tumors participated in the evaluation, each having two tumors, generally facial and symmetrical, in order to perform a comparative evaluation on the same individual. PROCEDURES: The glue was prepared beforehand with a sample of autologous blood. Surgical extirpation of the tumor was followed by grafts or second intention healing. OUTCOMES: The efficiency of the sealant was then evaluated in relation to hemostasis, adhesion, surgical time and evolution of the granulation tissue, clinically and histologically. RESULTS: Immediate hemostasis and graft adhesion, with a significant reduction of surgical time, and in the open wounds there was immediate hemostasis and a clinical increase in granulation tissue, but with no histological differences among the groups on the 7th day. CONCLUSION: It is an adjuvant resource in skin cancer surgery.
Downloads
References
Gibble JW, Ness PM. Fibrin glue: the perfect operative sealant? Transfusion 1990;30:741-7.
Dyson M et al. Comparison of the effects of moist and dry conditions on dermal repair. J Invest Dermatol 1988;91:434-9.
Galletti G et al. La cicatrizzazione delle ferite: effecto protettivo della colla di fibrina? Minerva Chirurgica 1985;40:377-80.
Chakravorty RC, Sosnowiski KM. Autologous fibrin glue in full-thickness skin grafting. Ann Plast Surg 1989; 23:488-91.
Dahlstrom KK, Weis-Fogh US, Medgyesi S, Rostgaard J, Sorensen H. The use of autologous fibrin adhesive in skin transplantation. Plast Reconstr Surg 1992;89:968-72; discussion 973-6.
Eaglestein WH. Experiences with biosynthetic dressings. J Am Ac Dermatol 1985;12:434-40.
Harting F et al. Glue fixation of split-skin graft to the bony orbit following exenteration. Plast Reconst Surg 1985;76:633-5.
Lilius P. Fibrin adhesive: its use in sealed skin grafting. Scand J Plast Reconstr Hand Surg 1987;21:245-8.
Kram HB et al. Spraying of aerosolized fibrin glue in the treatment of nonsuturable hemorrhage. Am Surg 1991;57:381-4.
Jabs AD et al. The effect of fibrin glue on skin grafts in infected sites. Plast Reconstr Surg 1992;89:268-71.
Bizzachi JMA et al. Utilisation de la colle de fibrine autologue en reconstruction faciale par greffes de peau totale. Ann Chir Plast Esthét 1994;39:125-7.
Byrne DJ et al. Effect of fibrin glues on the mechanical properties of healing wounds. Br J Surg 1991;78:841-3.
Brown, DM et al. Decrease wound contraction with fibrin glue-treated skin grafts. Arch Surg 1992:127:404-6
Kram HB et al. Use fibrin glue in hepatic trauma. N Trauma 1988;28:1195-2015.
Kram HB et al. Tracheal repair with fibrin glue. J Thorac Cardiovasc Surg 1985;90:771.
Matras H et al. Suture-free interfascicular nerve transplantation in animal experiments. Wien Med Wochenschr 1972;122:517-23.
Ronfard V et al. Use of human keratinocytes cultured on fibrin glue in the treatment of burn wounds. Burns 1991;17:181-4.
Ormann W, Hopf G. Spontaneous splenic rupture in infectious mononucleosis - Organ preserving operation by means of fibrin tissue adhesive. Langenbecks Arch Chir 1988;373:240-2.
Matras H. The use of fibrin sealant in oral and maxillofacial surgery. J Oral Maxillofac Surg 1982;40:617-22.
Wolner E. Fibrin gluing in cardiovascular surgery. Thorac Cardiovas Surg 1982;30:236-7.
Saltz et al. Application of autologous fibrin glue in burn wounds. J Burn Care Rehabil 1989;10:504-7.
Siedentop KH et al. Autologous fibrin tissue adhesive. Laryngoscope 1985;95:1074-6.
Stuart JD, Morgan RF, Keney JG. Single-donor fibrin glue for hand burns. Ann Plast Surg 1990;24:524-7.
Tildrik RT, Warner E. Fibrin fixation of skin transplants. Surgery 1984;15:90.
Dresdale A et al. Preparation of fibrin glue from single-donor fresh-frozen plasma. Surgery 1985;97:750-5.
