Anticardiolipin antibody in recurrent spontaneous aborting and fertile women
Keywords:
Anticardiolipin antibody, Recurrent spontaneous abortion, Immunology, Antiphospholipid syndromeAbstract
OBJECTIVE: To determine the association between the presence of anticardiolipin antibody and a history of recurrent spontaneous abortion. STUDY DESIGN: clinical controlled study LOCATION: Department of Gynecology and Obstetrics - University of Campinas (UNICAMP) SUBJECTS: 52 individuals with recurrent spontaneous abortion were included in Group 1 and 104 individuals with at least one live born child in Group 2. Elapsed time from last delivery to blood sampling varied from six months to two years. METHOD: Between November 1993 and November 1994, patients' blood samples were screened for anticardiolipin antibody by ELISA, as described by Triplett, Barna and Unger (1993). ANALYSIS: Chi-square and Fisher's Exact tests were used for statistical analysis. Student's "t" test was used to compare the means. RESULTS: There was no statistical difference in the presence of the anticardiolipin antibody between Group I (zero and 2.9%) and Group 2 (7.7 and 5.8%). CONCLUSION: There was no association between the presence of anticardiolipin antibody and recurrent spontaneous abortion.
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Lockshin MD, Qamar T, Levy RA. Anticardiolipin and related antibodies: thrombosis and fetal death. In: Scott JS, Bird HA, editors. Pregnancy, autoimmunity, and connective tissue disorders. 5th ed. Oxford: Oxford University Press 1990;185-211.
Branch DW, Silver RM, Blackwell JL, Reading JC, Scott JR. Outcome of treated pregnancies in women with antiphospholipid syndrome: an update of the Utah experience. Obstet Gynecol 1992;80:614-20.
Out HJ, Bruinse HW, Christiaens GCML, Van Vliet M, De-Groot PG, Nieuwenhuis HK, Derksen RHWM. A prospective, controlled multicenter study on the obstetric risks of pregnant women with antiphospholipid antibodies. Am J Obstet Gynecol 1992;167:26-32.
Triplett DA. Obstetrical complications associated with antiphospholipid antibodies. In: Coulam CB, Faulk WP, McIntyre JA, editors. Immunological obstetrics. London: Norton Medical Books 1992;377-403.
Kwak JYH, Barini R, Gilman-Sachs A, Beaman KD, Beer AE. Down-regulation of maternal antiphospholipid antibodies during early pregnancy and pregnancy outcome. Am J Obstet Gynecol 1994;171:239-46.
Rosove MH, Tabsh K, Wasserstrum N, Howard P, Hahn BH, Kalunian KC. Heparin therapy for pregnant women with lupus anticoagulant or anticardiolipin antibodies. Obstet Gynecol 1990;75:630-4.
Branch DW, Scott JR, Kochenour NK, Hershgold E. Obstetric complications associated with the lupus anticoagulant. N Engl J Med 1985;313:1322-6.
Arthurs M, Morgan OSC, Deceulaer K, Browne B. Primary antiphospholipid syndrome: a case report. West Indian Med J 1994;43:27-9.
Lynch A, Marlar R, Murphy J, Davila G, Santos M, Rutledge J, Emlen W. Antiphospholipid antibodies in predicting adverse pregnancy outcome: a prospective study. Ann Intern Med 1994;120:470-5.
Costa HLFF, Moura MD, Ferriani RA, Anceschi MIS, Barbosa JE. Prevalence of anti-cardiolipin antibody in habitual aborters. Gynecol Obstet Invest 1993;36:221-5.
Triplett DA, Barna L, Unger G. Laboratory identification of lupus anticoagulants. XIVth Congress of the International Society on Thrombosis and Haemostasis. Indiana, 1993. New York: Hilton & Towers 1993;70-9.
Harris EN, Phil M. The second international anti-cardiolipin standardization workshop: the Kingston anti-phospholipid antibody study (KAPS) group. Am J Clin Pathol 1990;94:476-84.
Branch DW. Immunologic disease and fetal death. Clin Obstet Gynecol 1987;30:295-311.
Pattison NS, Chamley LW, McKay EJ. Prevalence of antiphospholipid antibodies in a normal pregnant population. Clin Exp Rheumatol 1988;6:210
Cowchock S, Smith JB, Gocial B. Antibodies to phospholipids and nuclear antigens in patients with repeated abortions. Am J Obstet Gynecol 1986;155:1002-10.
Clauvel JP, Tchobroutsky C, Danon F, Sultan Y, Intrator L, Brouet JC. Spontaneous recurrent fetal wastage and autoimmune abnormalities: a study of fourteen cases. Clin Immunol Immunopathol 1986;39:523-30.
Bocciolone L, Meroni P, Parazzini F, et al. Antiphospholipid antibodies and risk of intrauterine late fetal death. Acta Obstet Gynecol Scand 1994;73:389-92.
El-Roeiy A, Gleicher N. Definition of normal autoantibody levels in an apparently healthy population. Obstet Gynecol 1988;72:596-602.
Lenzi R, Rand JH, Spiera H. Anticardiolipin antibodies in pregnant patients with systemic lupus erythematosus. N Engl J Med 1986;314:1392-3.
Rupin A, Gruel Y, Watier H, Girard AC, Leroy J, Bardos P. ELISA for the detection of anticardiolipin antibodies: high specificity based on the use of adult bovine serum as buffer and systematic subtraction of non-specific binding. J Immunol Meth 1991;138:225-31.
Harris EN, Phil M. A reassessment of the antiphospholipid syndrome. J Rheumatol 1990;17:733-5 [Editorial].
Barbui T, Radici E, Cortelazzo S, et al. Antiphospholipid antibodies in early repeated abortions: a case-controlled study. Fertil Steril 1988;50:589-92.
Sanchez-Guerrero J, Alarcón-Segovia, D. Course of antiphospholipid antibodies in patients with primary antiphospholipid syndrome before, during and after pregnancy treated with low dose aspirin: relationship of antibody levels to outcome in 7 patients. J Rheumatol 1992;19:1083-8.
Lubbe WF, Butler WS, Palmer SJ, Liggins GC. Lupus anticoagulant in pregnancy. Br J Obstet Gynaecol 1984;91:357-63.
Harris EN. Antiphospholipid antibodies. Br J Haematol 1990;74:1-9 [Annotation].
Love PE, Santoro SA. Antiphospholipid antibodies: anticardiolipin and the lupus anticoagulant in systemic lupus erythematosus (SLE) and in non-SLE disorders: prevalence and clinical significance. Ann Inter Med 1990;112:682-98.
Kwak JYH, Ober C, Barini R, Beer AE. Maternal autoimmune abnormalities and fetal HLA-DQ A1 alleles in women with recurrent spontaneous abortion (RSA). In: Proceedings of the thirty-ninth annual meeting of the Society for Gynecologic Investigation. San Antonio, Texas, March 18-21: Society for Gynecologic Investigation 1992;363.
Vianna JL, Haga HJ, Tripathi P, Cervera R, Khamashta MA, Hughes GRV. Reassessing the status of antiphospholipid syndrome in systemic lupus erythematosus. Ann Rheum Dis 1992;51:160-1.
MacAean MA, Cumming GP, McCall F, Walker ID, Walker JJ. The prevalence of lupus anticoagulant and anticardiolipin antibodies in women with a history of first trimester miscarriages. Br J Obstet Gynaecol 1994;101:103-6.
Harris EN, Phil M. Solid-phase anti-cardiolipin test revisited. Am J Med 1988;85:599-601 [Editorial].
