Cellular angiofibroma of the vulva

case report with clinicopathological and immunohistochemistry study

Authors

  • Adilha Misson Rua Micheletti Universidade Federal do Triângulo Mineiro
  • Ana Cristina Araújo Lemos da Silva Universidade Federal do Triângulo Mineiro
  • Antonio Geraldo Nascimento Universidade Federal do Triângulo Mineiro
  • Cléber Sérgio Da Silva Universidade Federal do Triângulo Mineiro
  • Eddie Fernando Candido Murta Universidade Federal do Triângulo Mineiro
  • Sheila Jorge Adad Universidade Federal do Triângulo Mineiro

Keywords:

Angiofibroma, Connective tissue, Mesoderm, Neoplasm, Vulva

Abstract

CONTEXT: Cellular angiofibroma of the vulva is a rare tumor that was first described in 1997. It occurs in middle-aged women (average age: 47 years), has small size (< 3 cm) and well-cir-cumscribed margins. CASE REPORT: We describe a case in a 51-year- old woman whose preoperative diagnosis was confounded with Bartholin’s glandular cyst. The neoplasia was well delimited and made up of three characteristic components: fusiform cells forming small fascicles, numerous blood vessels and adipose tissue interspersed between the fusiform cells. The stroma cells were positive for vimentin and negative for CD34, protein S-100, actin and desmin. The differential diagnoses for this tumor include aggressive angiomyxoma, angiomyofibroblastoma, lipoma of fusiform cells, solitary fibrous tumor, perineurioma and leiomyoma.

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Author Biographies

Adilha Misson Rua Micheletti, Universidade Federal do Triângulo Mineiro

MD, PhD. Substitute Professor of Discipline of Special Pathology, Universidade Federal do Triângulo Mineiro, Uberaba, Minas Gerais, Brazil.

Ana Cristina Araújo Lemos da Silva, Universidade Federal do Triângulo Mineiro

MD. Resident doctor of Pathology, Universidade Federa Universidade Federal do Triângulo Mineiro, Uberaba, Minas Gerais, Brazil.

Antonio Geraldo Nascimento, Universidade Federal do Triângulo Mineiro

MD. Pathologist, specialist in Soft Tissue, Mayo Clinic, Rochester, Minnesota, United States.

Cléber Sérgio Da Silva, Universidade Federal do Triângulo Mineiro

MD. Substitute professor of Discipline of Gynecology and Obstetrics, Universidade Federal do Universidade Federal do Triângulo Mineiro, Uberaba, Minas Gerais, Brazil.

Eddie Fernando Candido Murta, Universidade Federal do Triângulo Mineiro

MD, PhD. Titular professor of Discipline of Gynecology and Obstetrics, Universidade Federal do Triângulo Mineiro, Minas Gerais, Brazil.

Sheila Jorge Adad, Universidade Federal do Triângulo Mineiro

MD, PhD. Associate professor of Discipline of Special Pathology, Universidade Federal do Triângulo Universidade Federal do Triângulo Mineiro, Uberaba, Minas Gerais, Brazil.

References

Nucci MR, Granter SR, Fletcher CD. Cellular angiofi- broma: a benign neoplasm distinct from angiomyofi- broblastoma and spindle cell lipoma. Am J Surg Pathol. 1997;21(6):636-44.

Nucci MR, Fletcher CD. Vulvovaginal soft tissue tumours: update and review. Histopathology. 2000;36(2):97-108.

Garijo MF, Val-Bernal JF. Extravulvar subcutaneous cellular angiofibroma. J Cutan Pathol. 1998;25(6):327-32.

Laskin WB, Fetsch JF, Mostofi FK. Angiomyofibroblastoma- like tumor of the male genital tract: analysis of 11 cases with comparison to female angiomyofibroblastoma and spindle cell lipoma. Am J Surg Pathol. 1998;22(1):6-16.

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Published

2005-09-09

How to Cite

1.
Micheletti AMR, Silva ACAL da, Nascimento AG, Silva CSD, Murta EFC, Adad SJ. Cellular angiofibroma of the vulva: case report with clinicopathological and immunohistochemistry study. Sao Paulo Med J [Internet]. 2005 Sep. 9 [cited 2025 Oct. 16];123(5):250-2. Available from: https://periodicosapm.emnuvens.com.br/spmj/article/view/2352

Issue

Vol. 123 No. 5 (2005)

Section

Case Report

License

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.