Pan-cytokeratin immunoexpression in Wilms' tumors
a simple approach for understanding tumor epithelial differentiation
Keywords:
Wilms' tumor, Immunohistochemistry, Cytokeratin, Kidney, Kidney neoplasmsAbstract
Wilms' tumor is one of the most common solid tumors in children and is an interesting model for understanding the pathogenesis of the embryonal tumors. Cytokeratins are intracellular fibrous proteins present in tissue of epithelial origin. The immunoexpression of the pan-cytokeratin AE1AE3 was studied in paraffin-embedded tissue sections from 24 Wilm s' tumors ( 12 with nephrogenic rests) and also tissue samples from 15 corresponding normal kidneys, to evaluate epithelial differentiation i n the gene sis d Wilms' rumor. We observed that the intensity of the expression d AE 1AE3 in the epithelial component of Wilms' tumors directly correlated with the degree of maturity of the e pithelial structures correspondent to the collecting ducts.
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References
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