Clinical management of six cases of low-risk primary tonsillar non-Hodgkin´s lymphoma
Keywords:
Non-Hodgkin´s lymphoma, Tonsil, Treatment, PrognosisAbstract
CONTEXT: There have been many reports that favor aggressive systemic treatment with chemotherapy and radiotherapy, even for well-localized lymphomas, avoiding the need for tonsillectomy of the normal tonsil. CASE REPORT: We report six cases of primary tonsillar lymphoma with a median patient age of 42 years. There were two lymphoma cases with diffuse large cells, two cases with mixed small and large cells, one with small cells and one indeterminate. They were treated with six cycles of chemotherapy and cervical radiotherapy. All patients achieved durable complete remission. Our data agree with previous reports that suggested that primary tonsillar high-grade B-cell NHL has a good prognosis if aggressively treated.
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References
Wright DH. Lymphomas of Waldeyer´s ring. Histopathology 1994;24:97-9.
Endo S, Kida A, Sawada U, et al. Clinical analysis of malignant lymphomas of tonsil. Acta Otolaryngol (Stockh) 1996;523:263-6.
Harris NL, Jaffe ES, Stein H, et al. Revised European-American classification of lymphoid neoplasms: a proposal from the international lymphoma study group. Blood 1994;84:1361.
Menarguez J, Mollejo M, Carrion R, et al. Waldeyer ring lymphomas: a clinicopathological study of 79 cases. Histopathology 1994;24:13-22.
Barton JH, Osborne BM, Butler JJ, et al. Non-Hodgkin´s lymphoma of the tonsil: a clinicopathological study of 65 cases. Cancer 1984;53:86-95.
Fujitani T, Takahara T, Hattori H, Imajo Y, Ogasawara H. Radiochemotherapy for non-Hodgkin´s lymphoma in palatine tonsil. Cancer 1984;54:1288-92.
Carbone P, Kaplan HS, Musholf K. Report of the committee of Hodgkin´s disease staging classification. Cancer Res 1971;31(11):1860-1.
Barista I, Tekuzman G, Güllü I, et al. Non-Hodgkin´s lymphomas of the tonsil: a retrospective analysis of twenty-eight patients with primary tonsillar lymphoma. Tumori 1995;81:234-7.
Shipp MA, et al. A predictive model for aggressive non-Hodgkin´s lymphoma: the International Non-Hodgkin´s Lymphoma Prognostic Factors Project. N Engl J Med 1993;329(14):987-94.
Shipp MA. Prognostic factors in aggressive non-Hodgkin´s lymphoma: who has high-risk disease? Blood 1994;83(5):1165-73.