Severity and prognosis in intensive care
prospective application of the Apache II Index
Keywords:
Severity, Mortality, Intensive Care, APACHE IIAbstract
CONTEXT: The performance of each ICU needs to be assessed within the overall context of medical care, as well as by the institution which the ICU forms part of. Evaluation mechanisms in the field of intensive care have been developed that are recognized worldwide within the scientific literature. OBJECTIVE: To study outcomes from groups of critical patients and to compare their actual and estimated mortality rates. DESIGN: Prospective study of patients' outcomes. SETTING: A tertiary care unit for a period of 13 months (anesthesiology intensive care unit at the Escola Paulista de Medicina). PARTICIPANTS: 520 patients selected according to sex, age and nature of hospitalization. DIAGNOSTIC TEST: The modified APACHE II prognostic index was applied in order to assess clinical severity and anticipation of mortality in three groups who had non-surgical treatment, emergency surgery and elective surgery. MAIN MEASUREMENTS: The APACHE II index. RESULTS: The application of this index allowed patients to be stratified and expected death risks for both subgroups and the entire sample population to be calculated. The observed mortality rate was greater than the expected rate (28.5% versus 23.6%, respectively), with a statistically significant difference. The standardized mortality rate was 1.20. Patients who obtained scores above 25 presented a significant outcome towards death. The most severe and worst evolving cases were, in decreasing order: non-surgical, emergency surgical and scheduled surgical patients; the actual general mortality rate was higher than the expected one. CONCLUSIONS: The use of the APACHE II index made it possible to stratify critical patient groups according to the severity of their condition.
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References
Bendixen HH, Kinney JM. História do tratamento intensivo. In: Kinney JM, Bendixen HH, Powers SR, editors. Assistencia Cirúrgica Intensiva. Rio de Janeiro: Interamericana; 1979:1-9.
NIH Consensus Development Conference on Critical Care Medicine. Crit Care Med 1983;6:466-9.
Cullen DJ. Results and costs of intensive care. Anesthesiology 1997;2:203-16.
Chalfin DB, Fain AM. Cost-containment in the United States: critical care medicine in managed competition and managed care environment. New Horizons 1994;2:275-82.
Knaus WA, Draper EA, Wagner DP. An evaluation of outcome from intensive care in major medical centers. Ann Intern Med 1986;104:410-8.
Knaus WA, Zimmermann JE, Wagner DP, Draper EA, Lawrence DE. APACHE: acute physiology and chronic health evaluation: a physiologically based classification system. Crit Care Med 1981;9:591-603.
Knaus WA, Draper EA, Wagner DP, Zimmermann JE. APACHE II: a severity of disease classification system. Crit Care Med 1985;10:818-29.
Zimmermann JE. APACHE III study design: analytic plan for evaluation of severity and outcome. Crit Care Med 1989;17:S169-221.
Cullen DJ, Civetta JM, Briggs BA, Ferrara L. Therapeutic intervention scoring system: a method for quantitative comparison of patient care. Crit Care Med 1974;2:57-60.
Knaus WA. Prognosis with mechanical ventilation: the influence of disease, age, and chronic health status on survival from an acute illness. Am Rev Respir Dis 1989;140:S8-13.
Chang RW, Lee B, Jacobs S, Lee B. Accuracy of decisions to withdraw therapy in critically ill patients: clinical judgment versus a computer model. Crit Care Med 1989;17:1091-7.
Cochran WG. Some methods for strengthening the common c2 test. Biometrics 1954;10:417-51.
Siegel S. Estadística no paramétrica. Mexico: Trillas; 1975:346-61.
Cowley RA, Sacco WJ, Gill W, et al. A prognostic index for severe trauma. J Trauma 1974;14:1029-35.
Norris RM, Brandts PWT, Lee AJ. Mortality in a coronary care unit analysed by a new coronary prognostic index. Lancet 1969;i:278-81.
Baker SP, O'Neill F, Haddon WJ. The injury severity score: a method for describing patients with multiple injuries and evaluating emergency care. J Trauma 1974;14:187-96.
Shoemaker WC, Appel P, Bland R. Use of physiologic monitoring to predict outcome and to assist in clinical decisions in critically ill postoperative patients. Am J Surg 1983;146:43-50.
Sacco WJ. A prognostic index in critical care medicine. (Edgewood Arsenal Technical Report) EATR; 1973.
Keene AR, Cullen DJ. Therapeutic intervention scoring system: update 1983. Crit Care Med 1983;11:1-3.
Knaus WA, Wagner DP, Draper EA. The APACHE III prognostic system. Chest 1991;100:1619-36.
Seneff M, Knaus WA. Predicting patient outcome from intensive care: a guide to APACHE, MPM, SAPS, PRISM and other prognostic scoring systems. J Intensive Care Med 1990;5:33-52.
Becker RB, Zimmerman JE, Knaus WA, et al. The use of APACHE II to evaluate ICU length of stay, resource use, and mortality after coronary artery by-pass surgery. J Cardiovasc Surg 1995;36:1-11.
Wagner DP, Knaus WA, Draper EA. Identification of low-risk monitor admissions to medical-surgical ICUs. Chest 1987;117:511-9.
Ron A, Aronne LA, Kalb PE, et al. The therapeutic efficacy of critical care units. Arch Intern Med 1989;149:338-341.
Zimmerman JE, Knaus WA, Judson J, et al. Patient selection for intensive care: a comparison of New Zealand and United States hospitals. Crit Care Med 1988;16:318-26.
Marsh HM, Krishan I, Naessens JM, et al. Assessment of prediction of mortality by using the APACHE II scoring system in intensive care units. Mayo Clin Proc 1990;65:1549-57.
Rowan KM, Kerr JH, McPherson K, Short A, Vessey MP. Intensive Care Society's Acute Physiology and Chronic Health Evaluation (APACHE II) study in Britain and Ireland: a prospective, multicenter, cohort study comparing two methods for predicting outcome for adult intensive care patients. Crit Care Med 1994;22:1392-401.
Chang RW, Lee B, Jacobs S. Identifying ICU patients who would not benefit from total parenteral nutrition. J Parenter Enteral Nutr 1989;13:535-8.
Rogers J, Fuller H. Use of daily Acute Physiology and Chronic Health Evaluation (APACHE II) score to predict individual patient survival rate. Crit Care Med 1994;22:1402-5.
Giangiuliani G, Mancini A, Gui D. Validation of a severity of illness score (APACHE II) in a surgical intensive care unit. Intensive Care Med 1989;15:519-22.
Damiano A, Bergner M, Draper EA, Knaus WA, Wagner DP. Reliability of a measure of severity of illness: Acute Physiology and Chronic Health Evaluation II. J Clin Epidemiol 1992;45:93-101.
Livianu J, Ançăo MS, Akamine N, et al. Índices prognósticos em UTI. In: Knobel E, editor. Condutas no Paciente Grave. Săo Paulo: Atheneu; 1994:823-33.
Shaughnessy TE, Mickler TA. Does Acute Physiology and Chronic Health Evaluation (APACHE II) scoring predict need for prolonged support after coronary revascularization? Anesth Analg 1995;81:24-9.
Becker RB, Zimmerman JE, Knaus WA, et al. The use of APACHE III to evaluate ICU length of stay, resource use, and mortality after coronary artery by-pass surgery. J Cardiovasc Surg 1995;36:1-11.