Baseline laboratory parameters for preliminary diagnosis of COVID-19 among children

a cross-sectional study

Autores

Palavras-chave:

COVID-19, SARS-CoV-2, Child, Biomarkers

Resumo

BACKGROUND: Clinical judgment of initial baseline laboratory tests plays an important role in triage and preliminary diagnosis among coronavirus disease 2019 (COVID-19) patients. OBJECTIVES: To determine the differences in laboratory parameters between COVID-19 and COVID-like patients, and between COVID-19 and healthy children. Additionally, to ascertain whether healthy children or patients with COVID-like symptoms would form a better control group.DESIGN AND SETTING: Cross-sectional study at the Institute for Child and Youth Health Care of Vojvodina, Novi Sad, Serbia. METHODS: A retrospective study was conducted on 42 pediatric patients of both sexes with COVID-19. Hematological parameters (white blood cell count, absolute lymphocyte count and platelet count) and biochemical parameters (natremia, kalemia, chloremia, aspartate aminotransferase [AST], alanine amino-transferase [ALT], lactate dehydrogenase [LDH] and C-reactive protein [CRP]) were collected. The first control group was formed by 80 healthy children and the second control group was formed by 55 pediatric patients with COVID-like symptoms. RESULTS: Leukocytosis, lymphopenia, thrombocytosis, elevated systemic inflammatory index and neutro-phillymphocyte ratio, hyponatremia, hypochloremia and elevated levels of AST, ALT, LDH and CRP were present in COVID patients, in comparison with healthy controls, while in comparison with COVID-like controls only lymphopenia was determined. CONCLUSIONS: The presence of leukocytosis, lymphopenia, thrombocytosis, elevated systemic inflammatory index and neutrophil-lymphocyte ratio, hyponatremia, hypochloremia and elevated levels of AST, ALT, LDH and CRP may help healthcare providers in early identification of COVID-19 patients. Healthy controls were superior to COVID-like controls since they provided better insight into the laboratory characteristics of children with novel betacoronavirus (SARS-CoV-2) infection.

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Biografia do Autor

Dejan Dobrijević, Institute for Child and Youth Health Care of Vojvodina

MD. Clinical Biochemistry Resident and Teaching Assistant, Department of Biochemistry, Medical Faculty, University of Novi Sad, Serbia; and Physician, Department of Laboratory Diagnostics, Institute for Child and Youth Health Care of Vojvodina, Novi Sad, Serbia.

Jasmina Katanić, Institute for Child and Youth Health Care of Vojvodina

MD, PhD. Medical Biochemist, Department of Laboratory Diagnostics, Institute for Child and Youth Health Care of Vojvodina, Novi Sad, Serbia; and Assistant Professor, Department of Biochemistry, Medical Faculty, University of Novi Sad, Serbia.

Maša TodorovićI, Institute for Child and Youth Health Care of Vojvodina

MD. Laboratory Medicine Resident, Department of Laboratory Medicine, Clinical Center of Vojvodina, Novi Sad, Serbia; and Teaching Assistant, Department of Pathophysiology and Laboratory Medicine, Medical Faculty, University of Novi Sad, Serbia.

Biljana Vučković, Institute for Child and Youth Health Care of Vojvodina

MD, PhD. Internal Medicine Physician, Department of Laboratory Medicine, Clinical Center of Vojvodina, Novi Sad, Serbia; and Associate Professor, Department of Pathophysiology and Laboratory Medicine, Medical Faculty, University of Novi Sad, Serbia

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Publicado

2022-09-01

Como Citar

1.
Dobrijević D, Katanić J, TodorovićI M, Vučković B. Baseline laboratory parameters for preliminary diagnosis of COVID-19 among children: a cross-sectional study. Sao Paulo Med J [Internet]. 1º de setembro de 2022 [citado 14º de março de 2025];140(5):691-6. Disponível em: https://periodicosapm.emnuvens.com.br/spmj/article/view/1064

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