Comparação dos resultados maternos e fetais em pacientes submetidos a cesariana sob anestesia geral e raquianestesia
um ensaio clínico randomizado
Palavras-chave:
Cesárea, Anestesia geral, Hemoglobinas, Hematócrito, RaquianestesiaResumo
CONTEXTO E OBJETIVO: Como as taxas de partos cesáreos aumentaram, o tipo de anestesia na cesariana ganhou importância. Comparamos os efeitos da anestesia geral e da raquianestesia sobre os resultados maternos e fetais em casos de gestação única e no termo, com cesariana eletiva. TIPO DE ESTUDO E LOCAL: Ensaio clínico prospectivo, randomizado e controlado, em hospital público terciário. MÉTODOS: Estudo realizado com 100 pacientes que se submeteram a cesariana por indicação eletiva. As pacientes foram divididos aleatoriamente em grupos recebendo anestesia geral (n = 50) e raquianestesia (n = 50). Resultados maternos hematológicos pré e pós-operatórios, variáveis hemodinâmicas intra e pós-operatórias e resultados perinatais foram comparados entre os grupos. RESULTADOS: As médias de ruídos intestinais (P = 0,036) e tempo de descarga de gás (P = 0,049) foram significativamente mais elevadas e os valores de diferença de hemoglobina na 24a hora (P = 0,001) foram maiores no grupo anestesia geral. Os valores médios de hematócrito e hemoglobina na 24a hora (P = 0,004 e P < 0,001, respectivamente), o volume de urina na primeira hora de pós-operatório (P < 0,001) e a pontuação mediana de Apgar no primeiro minuto (P < 0,0005) foram significativamente maiores, e o tempo até o primeiro requerimento de analgésicos também foi significativamente maior (P = 0,042) no grupo raquianestesia. CONCLUSÃO: Nos casos eletivos, raquianestesia é superior à anestesia geral em termos de conforto pós-operatório. Em gestações com risco de sofrimento fetal, seria adequado preferir raquianestesia, levando em conta o Apgar no primeiro minuto. REGISTRO DE ENSAIO CLÍNICO: NTR17990
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Gori F, Pasqualucci A, Corradetti F, Milli M, Peduto VA. Maternal and neonatal outcome after cesarean section: the impact of anesthesia. J Matern Fetal Neonatal Med. 2007;20(1):53-7.
Liu S, Liston RM, Joseph KS, et al. Maternal mortality and severe morbidity associated with low-risk planned cesarean delivery versus planned vaginal delivery at term. CMAJ. 2007;176(4):455-60.
Ronsmans C, Graham WJ; Lancet Maternal Survival Series steering group. Maternal mortality: who, when, where, and why. Lancet. 2006;368(9542):1189-200.
Tsen LC. Anesthesia for cesarean section. In: Chestnut DH, Polley LS, Wong CA, Tsen LC, editors. Chestnut’s obstetric anesthesia: principles and practice. 4th ed. Philadelphia: Elsevier Mosby; 2009. p. 521-51.
Cooper MG, McClure JH. Anaesthesia. In: Lewis G, Drife J, editors. Why mothers die 2000-2002. Confidential enquiries into maternal and child health. Improving care for mothers, babies and children. London: RCOG Press; 2004. p. 122-33.
Ngan Kee WD. Confidential enquiries into maternal deaths: 50 years of closing the loop. Br J Anaesth. 2005;94(4):413-6.
Reynolds F. General anesthesia is unacceptable for elective cesarean section. Int J Obstet Anesth. 2010;19(2):212-7.
Bucklin BA, Hawkins JL, Anderson JR, Ullrich FA. Obstetric anesthesia workforce survey: twenty-year update. Anesthesiology. 2005;103(3):645-53.
Kavak ZN, Başgül A, Ceyhan N. Short-term outcome of newborn infants: spinal versus general anesthesia for elective cesarean section. A prospective randomized study. Eur J Obstet Gynecol Reprod Biol. 2001;100(1):50-4.
Mattingly JE, D’Alessio J, Ramanathan J. Effects of obstetric analgesics and anesthetics on the neonate: a review. Paediatr Drugs. 2003;5(9):615-27.
Littleford J. Effects on the fetus and newborn of maternal analgesia and anesthesia: a review. Can J Anaesth. 2004;51(6):586-609.
Richardson MG. Regional anesthesia for obstetrics. Anesthesiol Clin North America. 2000;18(2):383-406.
Laudenbach V, Mercier FJ, Rozé JC, et al. Anaesthesia mode for caesarean section and mortality in very preterm infants: an epidemiologic study in the EPIPAGE cohort. Int J Obstet Anesth. 2009;18(2):142-9.
Van de Velde M, Schepers R, Berends N, Vandermeersch E, De Buck F. Ten years of experience with accidental dural puncture and post-dural puncture headache in a tertiary obstetric anaesthesia department. Int J Obstet Anesth. 2008;17(4):329-35.
Bloom SL, Spong CY, Weiner SJ, et al. Complications of anesthesia for cesarean delivery. Obstet Gynecol. 2005;106(2):281-7.
Kolås T, Saugstad OD, Daltveit AK, Nilsen ST, Øian P. Planned cesarean versus planned vaginal delivery at term: comparison of newborn infant outcomes. Am J Obstet Gynecol. 2006;195(6):1538-43.
Jenkins JG, Khan MM. Anaesthesia for Caesarean section: a survey in a UK region from 1992 to 2002. Anaesthesia. 2003;58(11):1114-8.
Gogarten W. Spinal anaesthesia for obstetrics. Best Pract Res Clin Anaesthesiol. 2003;17(3):377-92.
Ng K, Parsons J, Cyna AM, Middleton P. Spinal versus epidural anaesthesia for caesarean section. Cochrane Database Syst Rev. 2004;(2):CD003765.
Hawkins JL. Obstetric analgesia and anesthesia. In: Gibbs RS, Karlan BY, Haney AF, Nygaard I, editors. Danforth’s obstetrics and gynecology. 10th edition. Philadelphia: Lippincott, Williams & Wilkins; 2010. p. 43-59.
Klöhr S, Roth R, Hofmann T, Rossaint R, Heesen M. Definitions of hypotension after spinal anaesthesia for caesarean section: literature search and application to parturients. Acta Anaesthesiol Scand. 2010;54(8):909-21.
Maayan-Metzger A, Schushan-Eisen I, Todris L, Etchin A, Kuint J. Maternal hypotension during elective cesarean section and short-term neonatal outcome. Am J Obstet Gynecol. 2010;202(1):56.e1-5.
Ngan Kee WD. Prevention of maternal hypotension after regional anaesthesia for caesarean section. Curr Opin Anaesthesiol. 2010;23(3):304-9.
Shin BS, Ko JS, Gwak MS, et al. The effects of prehydration on the properties of cerebrospinal fluid and the spread of isobaric spinal anesthetic drug. Anesth Analg. 2008;106(3):1002-7.
Harten JM, Boyne I, Hannah P, Varveris D, Brown A. Effects of a height and weight adjusted dose of local anaesthetic for spinal anaesthesia for elective Caesarean section. Anaesthesia. 2005;60(4):348-53.
Hallworth SP, Fernando R, Columb MO, Stocks GM. The effect of posture and baricity on the spread of intrathecal bupivacaine for elective cesarean delivery. Anesth Analg. 2005;100(4):1159-65.
Desalu I, Kushimo OT. Is ephedrine infusion more effective at preventing hypotension than traditional prehydration during spinal anaesthesia for caesarean section in African parturients? Int J Obstet Anesth. 2005;14(4):294-9.
Macarthur A, Riley ET. Obstetric anesthesia controversies: vasopressor choice for postspinal hypotension during cesarean delivery. Int Anesthesiol Clin. 2007;45(1):115-32.
Lin FQ, Qiu MT, Ding XX, Fu SK, Li Q. Ephedrine versus phenylephrine for the management of hypotension during spinal anesthesia for cesarean section: an updated meta-analysis. CNS Neurosci Ther. 2012;18(7):591-7.
Loubert C. Fluid and vasopressor management for Cesarean delivery under spinal anesthesia: continuing professional development. Can J Anaesth. 2012;59(6):604-19.
Cooper DW. Caesarean delivery vasopressor management. Curr Opin Anaesthesiol. 2012;25(3):300-8.
Oh AY, Hwang JW, Song IA, et al. Influence of timing of administration of crystalloid on maternal hypotension during spinal anesthesia for cesarean delivery: preload versus coload. BMC Anesthesiol. 2014;14:36.
Afolabi BB, Lesi FE, Merah NA. Regional versus general anaesthesia for caesarean section. Cochrane Database Syst Rev. 2006;(4):CD004350.
Park GE, Hauch MA, Curlin F, Datta S, Bader AM. The effects of varying volumes of crystalloid administration before cesarean delivery on maternal hemodynamics and colloid osmotic pressure. Anesth Analg. 1996;83(2):299-303.
Nishikawa K, Yokoyama N, Saito S, Goto F. Comparison of effects of rapid colloid loading before and after spinal anesthesia on maternal hemodynamics and neonatal outcomes in cesarean section. J Clin Monit Comput. 2007;21(2):125-9.
Afolabi BB, Lesi FE. Regional versus general anaesthesia for caesarean section. Cochrane Database Syst Rev. 2012;10:CD004350.
Mancuso A, De Vivo A, Giacobbe A, et al. General versus spinal anaesthesia for elective caesarean sections: effects on neonatal short-term outcome. A prospective randomised study. J Matern Fetal Neonatal Med. 2010;23(10):1114-8.
Martin TC, Bell P, Ogunbiyi O. Comparison of general anaesthesia and spinal anaesthesia for caesarean section in Antigua and Barbuda. West Indian Med J. 2007;56(4):330-3.
Wong CA. General anesthesia is unacceptable for elective cesarean section. Int J Obstet Anesth. 2010;19(2):209-12.
Havas F, Orhan Sungur M, Yenigün Y, et al. Spinal anesthesia for elective cesarean section is associated with shorter hospital stay compared to general anesthesia. Agri. 2013;25(2):55-63.
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