Mudanças nas taxas de mastectomia em um hospital público brasileiro ao longo de 20 anos (1989 a 2008)
Palavras-chave:
Mastectomia, Mastectomia segmentar, Neoplasias da mama, Brasil, Estadiamento de neoplasiasResumo
CONTEXTO E OBJETIVO: Recentemente, a cirurgia conservadora tem substituído a mastectomia para tratamento cirúrgico do câncer de mama. O objetivo deste estudo é avaliar as mudanças nas taxas de mastectomia e cirurgia conservadora e os fatores relacionados a essas mudanças. TIPO DE ESTUDO E LOCAL: Estudo retrospectivo em hospital público brasileiro. MÉTODOS: Dados patológicos das pacientes submetidas a cirurgia para câncer de mama no Hospital das Clínicas, Universidade Federal de Minas Gerais (HC-UFMG), de 1989 a 2008, foram revistos. As taxas de mastectomia e cirurgia conservadora foram calculadas. O teste qui-quadrado foi usado para avaliar fatores relacionados ao tipo de tratamento cirúrgico empregado e comparar tendências de tipo de tratamento ao longo dos anos. Regressão logística foi usada para análise multivariada. RESULTADOS: De 1989 a 2008, 2.050 espécimes cirúrgicos de câncer de mama foram recebidos em nosso serviço, correspondentes a 1.973 pacientes; 1.324 (64,6%) correspondentes a mastectomia e 726 (35,4%) correspondentes a cirurgia conservadora. A cirurgia conservadora se tornou mais frequente ao longo dos anos (P < 0,001). Em análise multivariada, ano mais precoce da cirurgia (P < 0,001), maior tamanho tumoral (P < 0,001), ter ao menos um linfonodo axilar positivo (P < 0,001) e idade maior de 68 anos (P = 0,007) foram preditores de mastectomia. CONCLUSÕES: As cirurgias conservadoras se tornaram mais frequentes em relação às mastectomias ao longo dos anos. Isso pode refletir a consolidação da cirurgia conservadora (associada a radioterapia) como equivalente à mastectomia em termos de sobrevida, bem como diagnóstico mais precoce da doença.
Downloads
Referências
Brasil. Ministério da Saúde. Secretaria de Atenção à Saúde. Instituto Nacional de Câncer. Coordenação de Prevenção e Vigilância de Câncer. Estimativas 2008: Incidência de câncer no Brasil. Rio de Janeiro: INCA; 2007. Available from: http://bvsms.saude.gov.br/bvs/publicacoes/ estimativa_incidencia_cancer_2008.pdf. Accessed in 2012 (Mar 5).
Brasil. Ministério da Saúde. Instituto Nacional de Câncer. Estimativa 2010: Incidência de Câncer no Brasil. Rio de Janeiro: INCA; 2009. Available from: http://iah.iec.pa.gov.br/iah/fulltext/pc/monografias/outros/inca/ estimativa_2010_incidencia_cancer.pdf. Accessed in 2012 (Mar 5).
Lima-Costa MF, Matos DL. Prevalência e fatores associados à realização da mamografia na faixa etária de 50-69 anos: um estudo baseado na Pesquisa Nacional por Amostra de Domicílios (2003) [Prevalence and factors associated with mammograms in the 50-69-year age group: a study based on the Brazilian National Household Sample Survey (PNAD-2003)]. Cad Saúde Pública. 2007;23(7):1665-73.
Marchi AA, Gurgel MS. Adesão ao rastreamento mamográfico oportunístico em serviços de saúde públicos e privados [Adherence to the opportunistic mammography screening in public and private health systems]. Rev Bras Ginecol Obstet. 2010;32(4):191-7.
Halsted WS. I. The Results of Operations for the Cure of Cancer of the Breast Performed at the Johns Hopkins Hospital from June, 1889, to January, 1894. Ann Surg. 1894;20(5):497-555.
Halsted WS. I. The Results of Radical Operations for the Cure of Carcinoma of the Breast. Ann Surg. 1907;46(1):1-19.
Madden JL. Modified radical mastectomy. Surg Gynecol Obstet. 1965;121(6):1221-30.
Patey DH. A review of 146 cases of carcinoma of the breast operated on between 1930 and 1943. Br J Cancer. 1967;21(2):260-9.
Cotlar AM, Dubose JJ, Rose DM. History of surgery for breast cancer: radical to the sublime. Curr Surg. 2003;60(3):329-37.
Veronesi U, Saccozzi R, Del Vecchio M, et al. Comparing radical mastectomy with quadrantectomy, axillary dissection, and radiotherapy in patients with small cancers of the breast. N Engl J Med. 1981;305(1):6-11.
Veronesi U, Cascinelli N, Mariani L, et al. Twenty-year follow-up of a randomized study comparing breast-conserving surgery with radical mastectomy for early breast cancer. N Engl J Med. 2002;347(16):1227-32.
Fisher B, Bauer M, Margolese R, et al. Five-year results of a randomized clinical trial comparing total mastectomy and segmental mastectomy with or without radiation in the treatment of breast cancer. N Engl J Med. 1985;312(11):665-73.
Fisher B, Anderson S, Bryant J, et al. Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer. N Engl J Med. 2002;347(16):1233-41.
Fisher B. Biological and clinical considerations regarding the use of surgery and chemotherapy in the treatment of primary breast cancer. Cancer. 1977;40(1 Suppl):574-87.
NIH consensus conference. Treatment of early-stage breast cancer. JAMA. 1991;265(3):391-5.
Caldon LJ, Walters SJ, Reed JA, et al. Case-mix fails to explain variation in mastectomy rates: management of screen-detected breast cancer in a UK region 1997-2003. Br J Cancer. 2005;92(1):55-9.
Habermann EB, Abbott A, Parsons HM, et al. Are mastectomy rates really increasing in the United States? J Clin Oncol. 2010;28(21):3437-41.
Zorzi M, Puliti D, Vettorazzi M, et al. Mastectomy rates are decreasing in the era of service screening: a population-based study in Italy (1997-2001). Br J Cancer. 2006;95(9):1265-8.
Gomez SL, Lichtensztajn D, Kurian AW, et al. Increasing mastectomy rates for early-stage breast cancer? Population-based trends from California. J Clin Oncol. 2010;28(10):e155-7; author reply e158.
Katipamula R, Degnim AC, Hoskin T, et al. Trends in mastectomy rates at the Mayo Clinic Rochester: effect of surgical year and preoperative magnetic resonance imaging. J Clin Oncol. 2009;27(25):4082-8.
Damle S, Teal CB, Lenert JJ, et al. Mastectomy and contralateral prophylactic mastectomy rates: an institutional review. Ann Surg Oncol. 2011;18(5):1356-63.
McCahill LE, Privette AR, Hart MR, James TA. Are mastectomy rates a reasonable quality measure of breast cancer surgery? Am J Surg. 2009;197(2):216-21.
McGuire KP, Santillan AA, Kaur P, et al. Are mastectomies on the rise? A 13-year trend analysis of the selection of mastectomy versus breast conservation therapy in 5865 patients. Ann Surg Oncol. 2009;16(10):2682-90.
Suhrke P, Mæhlen J, Schlichting E, et al. Effect of mammography screening on surgical treatment for breast cancer in Norway: comparative analysis of cancer registry data. BMJ. 2011;343:d4692.
Adkisson CD, Vallow LA, Kowalchik K, et al. Patient age and preoperative breast MRI in women with breast cancer: biopsy and surgical implications. Ann Surg Oncol. 2011;18(6):1678-83.
Tiezzi DG, Andrade JM, Marana HR, Zola FE, Peria FM. Breast conserving surgery after neoadjuvant therapy for large primary breast cancer. Eur J Surg Oncol. 2008;34(8):863-7.
Morrow M. Limiting breast surgery to the proper minimum. Breast. 2005;14(6):523-6.
Ballinger RS, Mayer KF, Lawrence G, Fallowfield L. Patients’decision-making in a UK specialist centre with high mastectomy rates. Breast. 2008;17(6):574-9.
Morrow M, White J, Moughan J, et al. Factors predicting the use of breast-conserving therapy in stage I and II breast carcinoma. J Clin Oncol. 2001;19(8):2254-62.
Lee MC, Rogers K, Griffith K, et al. Determinants of breast conservation rates: reasons for mastectomy at a comprehensive cancer center. Breast J. 2009;15(1):34-40.
Hiotis K, Ye W, Sposto R, Skinner KA. Predictors of breast conservation therapy: size is not all that matters. Cancer. 2005;103(5):892-9.
Reitsamer R, Menzel C, Glueck S, Hitzl W, Peintinger F. Predictors of mastectomy in a certified breast center - the surgeon is an independent risk factor. Breast J. 2008;14(4):324-9.
Kirby RM, Basit A, Manimaran N. Patient choice significantly affects mastectomy rates in the treatment of breast cancer. Int Semin Surg Oncol. 2008;5:20.
Ess S, Savidan A, Frick H, et al. Geographic variation in breast cancer care in Switzerland. Cancer Epidemiol. 2010;34(2):116-21.
Caldon LJ, Collins KA, Wilde DJ, et al. Why do hospital mastectomy rates vary? Differences in the decision-making experiences of women with breast cancer. Br J Cancer. 2011;104(10):1551-7.
Greene FL, Page DL, Fleming ID, et al. AJCC cancer staging manual. 6th ed. New York: Springer-Verlag; 2002.
Kass GV. An exploratory technique for investigating large quantities of categorical data. Applied Statistics. 1980;29(2):119-27. Available from: http://www4.stat.ncsu.edu/~dickey/Analytics/Datamine/Reference%20 Papers/kass80.pdf. Accessed in 2012 (Mar 5).
Hosmer DW, Lemeshow S. Applied logistic regression. 2nd ed. New York: John Wiley and Sons; 2000.
Pagano M, Gauvreau K. Principles of biostatistics. 2nd ed. Pacific Grove: Duxbury; 2000.
Brasil. Ministério da Saúde. Controle do Câncer de Mama. Documento de Consenso. Rio de Janeiro: Instituto Nacional de Câncer; 2004. Available from: http://www.inca.gov.br/publicacoes/ Consensointegra.pdf. Accessed in 2012 (Mar 5).
Masood S. Why most women with breast cancer still undergo mastectomy. Breast J. 2003;9(2):69-70.
Chagpar AB, Studts JL, Scoggins CR, et al. Factors associated with surgical options for breast carcinoma. Cancer. 2006;106(7):1462-6.
Hurria A, Wong FL, Villaluna D, et al. Role of age and health in treatment recommendations for older adults with breast cancer: the perspective of oncologists and primary care providers. J Clin Oncol. 2008;26(33):5386-92.
Hurria A, Naeim A, Elkin E, et al. Adjuvant treatment recommendations in older women with breast cancer: a survey of oncologists. Crit Rev Oncol Hematol. 2007;61(3):255-60.
Han W, Kim SW, Park IA, et al. Young age: an independent risk factor for disease-free survival in women with operable breast cancer. BMC Cancer. 2004;4:82.
Bollet MA, Sigal-Zafrani B, Mazeau V, et al. Age remains the first prognostic factor for loco-regional breast cancer recurrence in young (< 40 years) women treated with breast conserving surgery first. Radiother Oncol. 2007;82(3):272-80.
Yabroff KR, Kerner JF. Variations in surgery for early-stage breast cancer: what are we measuring? Lancet. 2005;366(9481):188-90.
Passman LJ, Farias AM, Tomazelli JG, et al. SISMAMA--implementation of an information system for breast cancer early detection programs in Brazil. Breast. 2011;20 Suppl 2:S35-9.
Downloads
Publicado
Como Citar
Edição
Seção
Licença

Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.