Variations in white blood count, thromboxane B2 levels and hematocrit in chronic venous hypertension
Palavras-chave:
Venous ulcers, Venous insufficiency, White blood count, Thromboxane B2Resumo
OBJETIVOS: Analisar a variação do número de leucócitos e produção de tromboxane B2 em coleta na veia femoral de pacientes com hipertensão venosa crônica. TIPO DE ESTUDO: Estudo clínico, prospectivo, controlado, não randomizado e aberto LOCAL: Disciplina de Cirurgia Vascular, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo. PARTICIPANTES: Quinze doentes, com história pregressa de úlcera de estase venosa recidivada, selecionados aleatoriamente no Ambulatório de Doenças Venosas. Quatro pacientes sem alterações venosas dos membros inferiores. INTERVENÇÃO: Amostras de sangue colhidas na veia femoral e veia braquial após decúbito horizontal e proclive a 45º. VARIÁVEIS: Contagem dos leucócitos com câmara de contagem, e dosagem de tromboxane B2 com teste ELISA (Enzyme Linked Immunosorbent Assay). RESULTADOS: Após 30 minutos de proclive, houve redução na contagem de leucócitos de ±27% (p=0,02) e elevação na dosagem de tromboxane B2 de ±158% (p=0,02). CONCLUSÕES: Sugerimos que futuros estudos com medicações para tratamento de úlceras de estase avaliem a ação destes no seqüestro leucocitário e produção de tromboxane B2 e a correlação desta ação com o índice de cicatrização, no intuito de elucidar alguns aspectos importantes na etiologia das úlceras de estase.
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